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	题名	作者	年代	出处	被引量
1	Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.	Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o\|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer	2005	World Journal of Gastroenterology2005，11，44：	2
2	Amyloid_beta immunotherapy for Alzheimers disease:The end of the beginning显示文摘	Schenk D	2002	Nat Rev Neurosci2002，3，10：	1
3	Alzheimer's disease: molecular understanding predictsamyloid-based therapeutics 显示文摘	Selkoe DJ Schenk D	2003	Annu Rev Pharmacol Toxicol2003，43，：	1
4	Camparison of nine commercially available assays for quantification of antibody response to hepatitis B virus surface antigen显示文摘	Huzly D Schenk T Jilg W	2008	J Clin Microbiol2008，，46：	1
5	Analysis of vasculature for liver surgical Planning显示文摘	Preim B Schenk A	2002	IEEE transactions on medical imaging2002，，21：	1
6	Immunization with amyloid -beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse显示文摘	Schenk D Barbour R	1999	Nature1999，400，6740：	1
7	Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning显示文摘	Schenk D	2002	Nature Reviews2002，3，10：	1
8	An experimental test of the nature of predation: neither prey- norratio-dependent 显示文摘	Schenk D Bersier L and Bacher S	2005	J Animal Ecol、2005，74，：	1
9	Alzheimer′s disease:molecular understanding predicts amyloid-based therapeutics显示文摘	Selkoe DJ Schenk D		0，，06：	1
10	Comparison of Nine Com- mercially Available Assays for Quantification of Antibody Response to Hepatitis B Virus Surface Antigen 显示文摘	Huzly D Schenk W Jilg	2008	Clin Microbiol2008，46，4：	1
11	The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutations 显示文摘	FRYZEK J P GARABRANT D H SCHENK M	2006	Int J Gastrointest Cancer2006，37，4：	1
12	The role of cyto-protective cytokines in cardiac ischemia/reperfusion injury显示文摘	Anderson C D Heydarkhan S Schenke K	2007	J Surg Res2007，28，3：	1
13	Analysis of vasculature for liver surgery planning 显示文摘	Selle D Preim B Schenk A	2002	IEEE Trans Med Imaging2002，21，11：	1
14	Nonsurgical and surgical periodontal therapy in single - rooted teeth 显示文摘	Kim TS Schenk A Lungeanu D	2007	Clin Oral Invest2007，，10：	1
15	A resonantly excited 2D-micro-scanning-mirror with large deflection显示文摘	SCHENK H DRR P KUNZE D	2001	Sensors and Actuators2001，89，12：	1
16	Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse显示文摘	Schenk D Barbour R Dunn W	1999	Nature1999，400，6740：	1
17	β-peptide immunization: a possible newtreatment for Alzheimer disease显示文摘	Schenk D Seubert P Lieberburg I	2000	Arch Neurol2000，57，1：	1
18	Nonsurgical and surgical periodontal therapy in single-rooted teeth显示文摘	Kim TS Schenk A Lungeanu D		0，，04：	1
19	Gentamicin release from polymethylmethacrylate bone cements and Staphyloccus aureus biofilm formation显示文摘	Van de Belt H Neut D Schenk W		0，，：	1
20	Biologic Width around one- and two-piece titanium implants显示文摘	Hermann JS Buser D Schenk RK	2001	Clin Oral Implants Res2001，12，6：	1

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