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| 1 | Glutamine prevents oxidative stress in a model of mesenteric ischemia and reperfusion显示文摘AIM: To evaluate preventative effects of glutamine in an animal model of gut ischemia/reperfusion(I/R).METHODS: Male Wistar rats were housed in a controlled environment and allowed access to food and water ad libitum. Twenty male Wistar rats were divided into four experimental groups:(1) control group(control)- rats underwent exploratory laparotomy;(2) control + glutamine group(control-GLU)- rats were subjected to laparotomy and treated intraperitoneally with glutamine 24 and 48 h prior to surgery;(3) I/R group- rats were subjected to occlusion of the superior mesenteric artery for 30 min followed by 15 min of reperfusion; and(4) ischemia/reperfusion + glutamine group(G + I/R)- rats were treated intraperitoneally with glutamine 24 and 48 h before I/R. Local and systemic injuries were determined by evaluating intestinal and lung segments for oxidative stress using lipid peroxidation and the activity of superoxide dismutase(SOD), interleukin-6(IL-6) and nuclear factor kappa beta(NFkB) after mesenteric I/R. RESULTS: Lipid peroxidation of the membrane was increased in the animals subjected to I/R(P < 0.05). However, the group that received glutamine 24 and 48 h before the I/R procedure showed levels of lipid peroxidation similar to the control groups(P < 0.05). The activity of the antioxidant enzyme SOD was decreased in the gut of animals subjected to I/R when compared with the control group of animals not subjected to I/R(P < 0.05). However, the group that received glutamine 24 and 48 h before I/R showed similar SOD activity to both control groups not subjected to I/R(P < 0.05). The mean area of NF-kB staining for each of the control groups was similar. The I/R group showed the largest area of staining for NF-kB. The G + I/R group had the second highest amount of staining, but the mean value was much lower than that of the I/R group(P < 0.05). For IL-6, control and control-GLU groups showed similar areas of staining. The I/R group contained the largest area of IL-6 staining, followed by the G + I/R animals; however, this area was significantly lower than that of the group that underwent I/R without glutamine(P < 0.05). CONCLUSION: These results demonstrate that pretreatment with glutamine prevents mucosal injury and improves gut and lung recovery after I/R injury in rats. | Gilmara Pandolfo Zabot Gustavo Franco Carvalhal Norma Possa Marroni Renata Minuzzo Hartmann Vinícius Duval da Silva Henrique Sarubbi Fillmann | 2014 | World Journal of Gastroenterology2014，20，32： | 7 |
| 2 | Glutamine prevents oxidative stress in a model of portal hypertension显示文摘AIM To evaluate the protective effects of glutamine in a model of portal hypertension(PH) induced by partial portal vein ligation(PPVL).METHODS Male Wistar rats were housed in a controlled environment and were allowed access to food and water ad libitum. Twenty-four male Wistar rats were divided into four experimental groups:(1) control group(SO)-rats underwent exploratory laparotomy;(2) control + glutamine group(SO + G)-rats were subjected to laparotomy and were treated intraperitoneally with glutamine;(3) portal hypertension group(PPVL)-rats were subjected to PPVL; and(4) PPVL + glutamine group(PPVL + G)-rats were treated intraperitoneally with glutamine for seven days. Local injuries were determined by evaluating intestinal segments for oxidative stress using lipid peroxidation and the activities of glutathione peroxidase(GPx), endothelial nitric oxide synthase(e NOS) and inducible nitric oxide synthase(i NOS) after PPVL.RESULTS Lipid peroxidation of the membrane was increased in the animals subjected to PH(P < 0.01). However, the group that received glutamine for seven days after the PPVL procedure showed levels of lipid peroxidation similar to those of the control groups(P > 0.05). The activity of the antioxidant enzyme GTx was decreased in the gut of animals subjected to PH compared with that in the control group of animals not subjected to PH(P < 0.01). However, the group that received glutamine for seven days after the PPVL showed similar GTx activity to both the control groups not subjected to PH(P > 0.05). At least 10 random, non-overlapping images of each histological slide with 200 × magnification(44 pixel = 1 μm) were captured. The sum means of all áreas, of each group were calculated. The mean areas of e NOS staining for both of the control groups were similar. The PPVL group showed the largest area of staining for e NOS. The PPVL + G group had the second highest amount of staining, but the mean value was much lower than that of the PPVL group(P < 0.01). For i NOS, the control(SO) and control + G(SO + G) groups showed similar areas of staining. The PPVL group contained the largest area of i NOS staining, followed by the PPVL + G group; however, this area was significantly smaller than that of the group that underwent PH without glutamine(P < 0.01).CONCLUSION Treatment with glutamine prevents gut mucosal injury after PH in rats. | Gilmara Pandolfo Zabot Gustavo Franco Carvalhal Norma Possa Marroni Francielli Licks Renata Minuzzo Hartmann Vinícius Duval da Silva Henrique Sarubbi Fillmann | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 3 | Increased dispersion of ventricular recovery time as a new repolarization abnormality in the Wolff-Parkinson-White syndrome显示文摘 | Sarubbi B Briglia N | 1996 | int J Cardiol1996，56，3： | 1 |
| 4 | Enabling low-distortion varactors for adaptive transmitters 显示文摘 | Huang C De Vreede L C N Sarubbi F | 2008 | IEEE Transactions on Microwave Theory and Techniques2008，56，5： | 1 |
| 5 | A potential irdbctinn hazard associated with the use of disposable saline vials 显示文摘 | Rutala WA Stiegel MM Sarubbi FA | 1994 | Intection Control1994，5，： | 1 |
| 6 | Aortic and left ventricular remodeling in patients with bicuspid aortic valve without significant valvular dysfunction: A prospective study显示文摘 | Giuseppe Santarpia Giancarlo Scognamiglio Giovanni Di Salvo Michele D’Alto Berardo Sarubbi Emanuele Romeo Ciro Indolfi Maurizio Cotrufo Raffaele Calabrò | 2011 | International Journal of Cardiology2011，，3： | 1 |
| 7 | Right ventricular myocardial dysfunction in adult patients late after repair of tetralogy of fallot显示文摘 | D'Andrea A Caso P Sarubbi B | 2004 | Int J Cardiol2004，94，： | 1 |
| 8 | A pediatric case of cardiomyopathy induced by inappropriate sinus tachycardia:efficacy of ivabradine显示文摘 | Romeo E Grimaldi N Sarubbi B | | 0，，06： | 1 |
| 9 | Corynebacterium striatum:an underappreciated community and nosocomial pathogen显示文摘 | Lee PP Ferguson DAJr Sarubbi FA | 2005 | J Infect2005，4，： | 1 |
| 10 | Patulin in homogenized fruit's and tomato products显示文摘 | Sarubbi F Formisano G Auriemma G | 2016 | Food Control2016，，59： | 1 |
| 11 | Congenital junctional ec- topic taehycardia: presentation and outcome 显示文摘 | Sarubbi B Vergara P D' Alto M | 2003 | Indian Pacing Electrophysiol J2003，3，3： | 1 |
| 12 | Facilitation of pulmonary insulin absorption by H-MAP:pharmacokinetics and pharmacodynamics in rats显示文摘 | Uarez S Garcia Contreras L Sarubbi D | 2001 | Pharm Res2001，18，12： | 1 |
| 13 | Immediate and short-term cellular and biochemical responses to pulmonary singledose studies of insulin and H-MAP显示文摘 | Garcia Contreras L Sarubbi D Flanders E | 2001 | Pharm Res2001，18，12： | 1 |
| 14 | A potential infection hazard associated with the use of disposable saline vials显示文摘 | Rutala W A Stiegel M M Sarubbi F A Jr | 1984 | Infect Control1984，5，4： | 1 |
| 15 | Congenital junctional ectopic tachycardia in children and adolescents : a 20-year ex- perience-based study 显示文摘 | Sarubbi B Musto B Ducceschi V | 2002 | Heart2002，88，2： | 1 |
| 16 | Exercise capacity in young patients after total repair of tetralogy of Follot显示文摘 | Sarubbi B Pacileo G Pisacane C | 2000 | Pediatr Cardiol2000，21，： | 1 |
| 17 | Early electrical and geometric changes after percutaneous closure of large atrial septal defect显示文摘 | Giuseppe Santoro Marco Pascotto Berardo Sarubbi | 2004 | The American Journal of Cardiology2004，93，： | 1 |
| 18 | Partially unfolded protein efficiently penetrate cell membranes-implication for oral drug delivery 显示文摘 | Leipold H Sarubbi D | 1998 | J Controlled Release1998，53，： | 1 |
| 19 | Ionic mechanism of ischemia-related ventricular arrhythmias显示文摘 | Ducceschi V Di Micco G Sarubbi B | 1996 | Clin Cardiol1996，19，4： | 1 |
| 20 | A three-year study of nosocomial infections associated with Pseudomonas aeruginosa 显示文摘 | Sherertz R J Sarubbi F A | 1983 | Journal of Clinical Microbiology1983，18，1： | 1 |
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