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| 1 | MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a multi-faceted condition including simple steatosis alone or associated with inflammation and ballooning(non-alcoholic steatohepatitis) and eventually fibrosis.The NAFLD incidence has increased over the last twenty years becoming the most frequent chronic liver disease in industrialized countries.Obesity,visceral adiposity,insulin resistance,and many other disorders that characterize metabolic syndrome are the major predisposing risk factors for NAFLD.Furthermore,different factors,including genetic background,epigenetic mechanisms and environmental factors,such as diet and physical exercise,contribute to NAFLD development and progression.Several lines of evidence demonstrate that specific microRNAs expression profiles are strongly associated with several pathological conditions including NAFLD.In NAFLD,microRNA deregulation in response to intrinsic genetic or epigenetic factors or environmental factors contributes to metabolic dysfunction.In this review we focused on microRNAs role both as controlled and controllers molecules in NAFLD development and/or their eventual value as non-invasive biomarkers of disease. | Nadia Panera Daniela Gnani Annalisa Crudele Sara Ceccarelli Valerio Nobili Anna Alisi | 2014 | World Journal of Gastroenterology2014，20，41： | 9 |
| 2 | Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease显示文摘Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease(ALD). Currently, ALD is considered to be one of the major causes of death worldwide. An impaired intestinal barrier with related endotoxemia is among the various pathogenetic factors. This is mainly characterized by circulating levels of lipopolysaccharide(LPS), considered critical for the onset of intra-hepatic inflammation. This in turn promotes hepatocellular damage and fibrosis in ALD. Elevated levels of LPS exert their effects by binding to Toll-like receptors(TLRs) which are expressed by all liver-resident cells. The activation of TLR signaling triggers an overproduction and release of some cytokines, which promote an autocatalytic cascade of other proinflammatory signals. In this review, we provide an overview of the mechanisms that sustain LPS-mediated activation of TLR signaling, reporting current experimental and clinical evidence of its role during inflammation in ALD. | Sara Ceccarelli Valerio Nobili Anna Alisi | 2014 | World Journal of Gastroenterology2014，20，44： | 4 |
| 3 | Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial显示文摘 | Antonio Palumbo Sara Bringhen Tommaso Caravita Emanuela Merla Vincenzo Capparella Vincenzo Callea Clotilde Cangialosi Mariella Grasso Fausto Rossini Monica Galli Lucio Catalano Elena Zamagni Maria Teresa Petrucci Valerio De Stefano Manuela Ceccarelli Mari | 2006 | The Lancet2006，，9513： | 1 |
| 4 | Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies显示文摘 | Otilia E. Frasinariu Sara Ceccarelli Anna Alisi Evelina Moraru Valerio Nobili | 2013 | Digestive and Liver Disease2013，，7： | 1 |
| 5 | Slug/β-Catenin–Dependent Proinflammatory Phenotype in Hypoxic Breast Cancer Stem Cells显示文摘 | Gianluca Storci Sara Bertoni Sabrina De Carolis Alessio Papi Marina Nati Claudio Ceccarelli Chiara Pirazzini Paolo Garagnani Alberto Ferrarini Genny Buson Massimo Delledonne Michelangelo Fiorentino Elisa Capizzi Elisa Gruppioni Mario Taffurelli Donatella | 2013 | The American Journal of Pathology2013，，5： | 1 |
| 6 | Clinically-Staged T3N0 Rectal Cancer: Is Preoperative Chemoradiotherapy the Optimal Treatment?显示文摘 | Raffaele Lombardi Dajana Cuicchi Carmine Pinto Francesca Fabio Bruno Iacopino Stefano Neri Maria Lucia Tardio Claudio Ceccarelli Ferdinando Lecce Giampaolo Ugolini Sara Pini Piergiorgio Tullio Mario Taffurelli Francesco Minni Andrea Martoni Bruno Cola | 2010 | Annals of Surgical Oncology2010，，3： | 1 |
| 7 | Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies显示文摘 | Otilia E. Frasinariu Sara Ceccarelli Anna Alisi Evelina Moraru Valerio Nobili | 2013 | Digestive and Liver Disease2013，，7： | 1 |
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