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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Transient elastography: a new noninvasive method for assessment of hepatic fibrosis显示文摘 | Laurent Sandrin Bertrand Fourquet Jean-Michel Hasquenoph Sylvain Yon Céline Fournier Frédéric Mal Christos Christidis Marianne Ziol Bruno Poulet Farad Kazemi Michel Beaugrand Robert Palau | 2003 | Ultrasound in Medicine & Biology2003，，12： | 3 |
| 3 | A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver Resection显示文摘 | Jean–Charles Nault Aurélien De Reyniès Augusto Villanueva Julien Calderaro Sandra Rebouissou Gabrielle Couchy Thomas Decaens Dominique Franco Sandrine Imbeaud Francis Rousseau Daniel Azoulay Jean Saric Jean–Frédéric Blanc Charles Balabaud Paulette Bioulac | 2013 | Gastroenterology2013，，1： | 3 |
| 4 | Asymptotic optimality of likelihood-based Cross-Validation 显示文摘 | LAAN MARK VAN DER J SANDRINE D SUNDUZ K | 2004 | Statistical Applications in Genetics and Molecular Biolo- gy2004，3，： | 1 |
| 5 | Protracted release of the LHRH agonist avorelin (MF 6001) from two depot formulations in dogs and men显示文摘 | FRANGOIS B HELENE T SANDRINE D | 1997 | Lett Pept Sci1997，4，46： | 1 |
| 6 | Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy显示文摘 | Victor de Lédinghen Brigitte Le Bail Laurent Rebouissoux Céline Fournier Juliette Foucher Véronique Miette Laurent Castéra Laurent Sandrin Wassil Merrouche Frédéric Lavrand Thierry Lamireau | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，4： | 1 |
| 7 | Guidelines for xenotransplantation显示文摘 | Sykes M Sandrin M d'Apice AJF | 2003 | N Engl J Med2003，349，： | 1 |
| 8 | Silica-based coating for corrosion protection of electrogalvanized steel显示文摘 | Sandrine D Georges M Ricardo P N | 2005 | Surface and Coatings Technology2005，194，23： | 1 |
| 9 | Uremic Cardiomyopathy显示文摘 | Kristian K Yres D Sandrine M | 1998 | Nephrol Dial Transplant1998，13，14： | 1 |
| 10 | Inflammatory bowel disease in spouses and their offspring显示文摘 | David Laharie Stéphane Debeugny Marc Peeters André Van Gossum Corinne Gower-Rousseau Jacques Bélahe René Fiasse Jean-Louis Dupas Eric Lerebours Sandrine Piotte Antoine Cortot Séverine Vermeire Bruno Grandbastien Jean-Frédéric Colombel | 2001 | Gastroenterology2001，，： | 1 |
| 11 | Biochemical characterization of a recombinant TRIM5 alpha protein that restricts human immunodeficiency virus type 1 replication 显示文摘 | Langelier C R Sandrin V Eckert D M | 2008 | Joumal of Virology2008，82，11： | 1 |
| 12 | In vitro study on digestion of peptides in Emmental cheese:Analytical evaluation and influence on angiotensin converting enzyme inhibitory peptides显示文摘 | SANDRINE P PASCAL D | | Nahrung Food0，47，： | 1 |
| 13 | Involvement of oxidativesress and NADPH oxidase activation in the development of cardio-vascular complications in a model of insulin resistance,the fruc-tose-fed rat显示文摘 | Sandrine D Eleni p Richard M | 2005 | Atherosclerosis2005，179，1： | 1 |
| 14 | Uremic cardiomyopathy显示文摘 | Kristian K Yres D Sandrine M | 1998 | Nephrol Dial Transplant1998，13，4： | 1 |
| 15 | Molecular and biological screening for insect-toxic seed albumins from four legume species显示文摘 | Sandrine L Bernard D Frédéric G | 2004 | Plant Science2004，167，： | 1 |
| 16 | Respective roles of carbamylcholine and cyclic adenosine monophosphate in their synergistic regulation of cell cycle in thyroid primary cultures 显示文摘 | Alexander VK Sandrine D Jiri B | 2001 | Endocrinology2001，142，3： | 1 |
| 17 | Low-order ro- bust attitude control of an earth observation satellite 显示文摘 | Catherine V C Gilles D Sandrine L B | 1999 | Control Engineering Practice1999，7，： | 1 |
| 18 | Immune response against therapeutic factor W in hemophilia A pa- tients-A survey of probable risk factors 显示文摘 | Suryasarathi D Ana Maria N Sandrine D | 2007 | Immunol Let2007，110，2： | 1 |
| 19 | Centering ability and influence of experience when using waveone single-file technique in simulated canals显示文摘 | Mathieu G Sandrine D Pierre M | 2012 | Int J Dent2012，2012，20： | 1 |
| 20 | The yersinia high-pathogenicity island is present in different members of the family enterocoliticeae显示文摘 | Sandrine B Alzira D A | 2000 | FEMS Micriobiol Letter2000，183，2： | 1 |
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