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| 1 | Budesonide enema in pouchitis-a double-blind,double-dummy,controlled trial显示文摘 | Sambuelli A Boerr L Negreira S | 2002 | Alimentary Pharmacology&Therapeutics2002，16，1： | 1 |
| 2 | Experimental retinopathy of prematurity: angiostatic inhibition by nimodipine, ginkgo-biloba, and dipyridamole, and response to different growth factors显示文摘 | Guglielmone H Sambuelli R Echenique JR | 2000 | Eur J Ophthalmol2000，10，： | 1 |
| 3 | Bacillary angiomatosis affecting the oral cavity: Report of two cases and review 显示文摘 | Lopez de Blanc S Sambuelli R | 2000 | J Oral Pathol Med2000，29，1： | 1 |
| 4 | Multidrug resistance gene (MDRI) expression in the colonic mucosa of patients with refractory ulcerative colitis显示文摘 | Sambuelli AM Negreira SM Gil AH | | 0，，01： | 1 |
| 5 | Budesonide enema in pouchitis-a double-blind,double-dummy,controlled trial显示文摘 | Sambuelli A Boerr L Negreira S | 2002 | Aliment Pharmacol Ther2002，16，1： | 1 |
| 6 | Theoretical derivation of a peak particle velocity- distance law for the prediction of vibrations from blasting 显示文摘 | Sambuelli L | 2009 | Rock Mech Rock Eng2009，42，3： | 1 |
| 7 | Small choroidal melanoma with massive extraocular extension:invasion through posterior scleral emissary channels显示文摘 | Sambuelli R Luna J D Reviglio V E | | 0，，04： | 1 |
| 8 | Multidrug resistance gene (MDR-1) expression in the colonic mucosa of patients with refractory ulcerative colitis显示文摘 | Sambuelli AM Negreira SM Gil AH | | 0，，01： | 1 |
| 9 | Tomographie ultrasonore pour les arbressur pied Ann显示文摘 | Martinis R Socoo L V Sambuelli L | | 0，，： | 1 |
| 10 | Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies显示文摘Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to halted axon regeneration.Cross-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon regeneration.These effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so far.The aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhibitor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated fibers.Our results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of Y-27632.Treatment with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous sensitivity.In contrast,the same dose showed toxic effects on the regeneration of myelinated fibers.Interestingly,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only Y-27632.Overall,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b monoclonal antibody.Our findings open the possibility of therapeutic pharmacological intervention targeting Rho A/Rock pathway in immune neuropathies associated with the presence of anti-ganglioside antibodies and delayed or incomplete clinical recovery after injury in the peripheral nervous system. | Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez Rubén Sambuelli Kazim A.Sheikh Pablo H.H.Lopez | 2024 | Neural Regeneration Research2024，19，4： | 0 |
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