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| 1 | Genetic variant of cyclooxygenase-2 in gastric cancer:More inflammation and susceptibility显示文摘Gastric cancer accounts for the majority cancer-related deaths worldwide.Although various methods have considerably improved the screening,diagnosis,and treatment of gastric cancer,its incidence is still high in Asia,and the 5-year survival rate of advanced gastric cancer patients is only 10%-20%.Therefore,more effective drugs and better screening strategies are needed for reducing the incidence and mortality of gastric cancer.Cyclooxygenase-2(COX-2)is considered to be the key inducible enzyme in prostaglandins(PGs)synthesis,which is involved in multiple pathways in the inflammatory response.For example,inflammatory cytokines stimulate innate immune responses via Toll-like receptors and nuclear factor-kappa B to induce COX-2/PGE2 pathway.In these processes,the production of an inflammatory microenvironment promotes the occurrence of gastric cancer.Epidemiological studies have also indicated that non-steroidal antiinflammatory drugs can reduce the risk of malignant tumors of the digestive system by blocking the effect of COX-2.However,clinical use of COX-2 inhibitors to prevent or treat gastric cancer may be limited because of potential side effects,especially in the cardiovascular system.Given these side effects and low treatment efficacy,new therapeutic approaches and early screening strategies are urgently needed.Some studies have shown that genetic variation in COX-2 also play an important role in carcinogenesis.However,the genetic variation analysis in these studies is incomplete and isolated,pointing out only a few single nucleotide polymorphisms(SNPs)and the risk of gastric cancer,and no comprehensive study covering the whole gene region has been carried out.In addition,copy number variation(CNV)is not mentioned.In this review,we summarize the SNPs in the whole COX-2 gene sequence,including exons,introns,and both the 5’and 3’untranslated regions.Results suggest that COX-2 does not increase its expression through the CNV and the SNPs in COX-2 may serve as the potential marker to establish risk stratification in the general population.This review synthesizes emerging insights of COX-2 as a biomarker in multiple studies,summarizes the association between whole COX-2 sequence variation and susceptibility to gastric cancer,and discusses the future prospect of therapeutic intervention,which will be helpful for early screening and further research to find new approaches to gastric cancer treatment. | Xuan-Ke Ji Sailaja Vatsalya Madhurapantula Gui He Kun-Yan Wang Chun-Hua Song Jian-Ying Zhang Kai-Juan Wang | 2021 | World Journal of Gastroenterology2021，27，28： | 5 |
| 2 | Physiological Age Status of Female Adults and Off-Season Survival of Rice Leaffolder Cnaphalocrocis medinalis in India显示文摘Rice leaffolder, Cnaphalocrocis medinalis, is one of the major foliage feeders found in the rice growing regions in India. When the crop was at maturity, numerous adults of rice leaffolder were found in the rice fields though the larval population gradually decreased, and no eggs were found on rice leaves. The population characteristics of C. medinalis were assessed based on the physiological age status of adults at different crop growth stages. Based on egg development within ovarioles, ovariole appearance, number and colour of fat bodies, and characteristics of bursa copulatrix, physiological age status of the adults was described, which served as a basis for the determination of age composition. C. medinalis adults were found during the first week of August on rice plants, of which 44% were in Age 0 with immature ovaries, indicating immigrants. However, 28% adults each were at Ages 1–2 with developing ovaries, indicating local breeding population. The carryover and off-season survival of C. medinalis were also studied to determine the contribution of the alternative hosts in the population growth that helped in devising efficient management strategies. Rice was the most preferred host followed by Triticum aestivum, Echinochloa crusgulli and Brachiaria plantaginea. Various routes of the carryover of C. medinalis from season to season were discussed. | Padmavathi CHINTALAPATI Katti GURURAJ Sailaja VALLABUNI Prasad YENUMULAG | 2015 | Rice science2015，22，5： | 3 |
| 3 | Helicobacter pylori and gastric cardia cancer:What do we know about their relationship?显示文摘The incidence of gastric cardia cancer is increasing around the world.Since the discovery of Helicobacter pylori(H.pylori),numerous studies have proved that it is a causative factor for many kinds of digestive system tumors.Although the literature on gastric cardia cancer and H.pylori is not scarce,there are still many controversies on the relationship between gastric cardia cancer and H.pylori.Many Western research results showed that there was a negative or no correlation between H.pylori infection and gastric cardia cancer,but in several studies in Asian countries,such as China,H.pylori was demonstrated to be a risk factor for gastric cardia cancer.Therefore,we intended to analyze the related studies to find out the relationship between H.pylori and gastric cardia cancer and find out the causes of the above controversies.We also conducted a metaanalysis of the relationship between cagA positive expression of H.pylori and gastric cardia cancer,to find out whether there is an effect between those two.The primary purpose of this paper was to explore the relationship between gastric cardia cancer and H.pylori.Through analysis,the study showed the reasons for the controversies mentioned above:(1)Geographical factors could affect the relationship between H.pylori and gastric cardia cancer;(2)The definition of gastric cardia cancer in various studies is inconsistent.The result of a meta-analysis about the relationship between H.pylori virulence factor cagA and gastric cardia cancer showed that there was no relationship between these two. | Jing-Jing Yin Fu-Jiao Duan Sailaja Vatsalya Madhurapantula Yue-Hua Zhang Gui He Kun-Yan Wang Xuan-Ke Ji Kai-Juan Wang | 2020 | World Journal of Meta-Analysis2020，8，2： | 2 |
| 4 | Protective effect of Phyllanthus fraternus against allyl alcohol-induced oxidative stress in liver mitochondria显示文摘 | Sailaja R Setty OH | 2006 | J Ethnopharmacol2006，105，1： | 1 |
| 5 | Use of Poly( ethylene-co-vinyl alcohol)as Compatibilizer in LDPE/Thermoplastic Tapica Starch Blends 显示文摘 | Sailaja R R N Chanda M J | 2002 | Appl Polym Sci2002，86，： | 1 |
| 6 | Protective effect of Phyllanthus fraternus against allyl alcohol induced oxidative stress in liver mitochondria 显示文摘 | Sailaja R Setty OH | 2006 | J Ethnopharmacol2006，105，12： | 1 |
| 7 | Differential activation of phosphati- dylinositol 3 - kinase signaling during proliferation and differentia- tion of lens epithelial cells显示文摘 | Chandrasekher G Sailaja D | 2003 | Invest Ophthalmol Vis Sci2003，44，10： | 1 |
| 8 | CXCL16 signals via Gi, phoatedylinositol 3-kinas e, Akt, I kappa B kinase, and nuclear factor kappa B and induces cell-cell adhesion and aortic smooth muscle cell prolixferation 显示文摘 | Bysani C Sailaja B Srinivas M | 2004 | Biol Chem2004，279，： | 1 |
| 9 | In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood ceils using the comet assay and micronucleus test显示文摘 | Balasubramanyam A Sailaja N Mahboob M | 2009 | Mutagenesis2009，3，： | 1 |
| 10 | Use of poly(ethylene-co-vi-nyl alcohol) as compatibilizer in LDPE/thermoplastictapioca starch blends显示文摘 | Sailaja R R N Chanda M | 2002 | Journal of Applied PolymerScience?2002，86，： | 1 |
| 11 | Bacterial diversity of soil in the vicinity of Pindari glacier,Himalayan mountain ranges,India,using culturable bacteria and soil 16S r RNA gene clones显示文摘 | Shivaji S Pratibha M S Sailaja B | 2011 | Extremophiles2011，15，1： | 1 |
| 12 | Use of poly (ethylene-co- vinyl alcohol ) as compatibilizer in LDPE/thermoplastic tapioca starch blends 显示文摘 | SAILAJA R R N CHANDA M | 2002 | J Appl Polym Sci2002，86，12： | 1 |
| 13 | Preservation of the antioxidant status in chemically-induced diabetes mellitus by melatonin显示文摘 | Sailaja Devi MM Suresh Y Das J | 2000 | Pineal Res2000，29，： | 1 |
| 14 | The effect of L-carnitine supplementation on lipid parameters, inflammatory and nutritional markers in maintenance hemodialysis patients显示文摘 | Suchitra MM Ashalatha VL Sailaja E | 2011 | Saudi J Kidney Dis Transpl2011，22，6： | 1 |
| 15 | Thermoplastic composites from cyanoethylated wood and high density polyethylene显示文摘 | Sarkar A Pillay S A Sailaja R R N | 2001 | Journal of Polymer Materials2001，18，4： | 1 |
| 16 | Immunization with DNA,adenovirus or both in biodegradable alginate microspheres:effect of route of inoculation on immune response显示文摘 | Mittal SK Aggarwal N Sailaja G | 2000 | Vaccine2000，19，： | 1 |
| 17 | Optimal spot pricing in electricity market with inelastic load using constrained bat algorithm显示文摘 | M. Murali M. Sailaja Kumari M. Sydulu | 2014 | International Journal of Electrical Power and Energy Systems2014，，： | 1 |
| 18 | Preservation of the antioxidant status in chemically-induced diabetes mellitus by melatonin显示文摘 | Sailaja Devi MM Suresh Y Das | 2000 | J Pineal Res2000，29，2： | 1 |
| 19 | Hydroxyapatite filled chitosan-polyacrylic acid polyelectrolyte complexes 显示文摘 | Sailaja G S Velayudhan S Sunny M C | 2003 | Journal of Materials Science2003，38，： | 1 |
| 20 | Human immunodeficiency virus-like particles activate multiple types of immune cells显示文摘 | Sailaja G Skountzou I Quan FS | 2007 | Virology2007，362，2： | 1 |
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