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| 1 | Retrocaval liver lifting maneuver and modifications of total hepatic vascular exclusion for liver tumor resection显示文摘AIM: To evaluate the efficacy of technical modifications of total hepatic vascular exclusion(THVE) for hepatectomy involving inferior vena cava(IVC).METHODS: Of 301 patients who underwent hepatectomy during the immediate previous 5-year period, 8(2.7%) required THVE or modified methods of IVC cross-clamping for resection of liver tumors with massive involvement of the IVC. Seven of the patients had diagnosis of colorectal liver metastases and 1 had diagnosis of hepatocellular carcinoma. All tumors involved the IVC, and THVE was unavoidable for combined resection of the IVC in all 8 of the patients. Technical modifications of THVE were applied to minimize the extent and duration of vascular occlusion, thereby reducing the risk of damage.RESULTS: Broad dissection of the space behind the IVC coupled with lifting up of the liver from the retrocaval space was effective for controlling bleeding around the IVC before and during THVE. The procedures facilitate modification of the positioning of the cranial IVC cross-clamp. Switching the cranial IVC cross-clamp from supra- to retrohepatic IVC or to the confluence of hepatic vein decreased duration of the THVE while restoring hepatic blood flow or systemic circulation via the IVC. Oblique cranial IVC cross-clamping avoided ischemia of the remnant hemi-liver. With these technicalmodifications, the mean duration of THVE was 13.4 ± 8.4 min, which was extremely shorter than that previously reported in the literature. Recovery of liver function was smooth and uneventful for all 8 patients. There was no case of mortality, re-operation, or severe complication(i.e., Clavien-Dindo grade of Ⅲ or more).CONCLUSION: The retrocaval liver lifting maneuver and modifications of cranial cross-clamping were useful for minimizing duration of THVE. | Saiho Ko Yuuki Kirihatayfa Yayoi Matsumoto Tadataka Takagi Masanori Matsusaka Tomohide Mukogawa Hirofumi Ishikawa Akihiko Watanabe | 2016 | World Journal of Hepatology2016，8，8： | 5 |
| 2 | Transthoracic Transdiaphragmatic Approach for Hepatectomy of Couinaud’s Segments VII and VIII显示文摘 | Saiho Ko Yoshiyuki Nakajima Hiromichi Kanehiro Yukio Aomatsu Atsushi Yoshimura Junichiro Taki Tatsuya Kin Kazuaki Yagura Kazuo Ohashi Hiroshige Nakano | 1997 | World Journal of Surgery1997，，1： | 1 |
| 3 | Pivotal role of ADAMTS13 function in liver diseases显示文摘 | Masahito Uemura Yoshihiro Fujimura Saiho Ko Masanori Matsumoto Yoshiyuki Nakajima Hiroshi Fukui | 2010 | International Journal of Hematology2010，，1： | 1 |
| 4 | The Impact of Interferon Gamma Receptor Expression on the Mechanism of Escape From Host Immune Surveillance in Hepatocellular Carcinoma显示文摘 | Mitsuo Nagao Yoshiyuki Nakajima Hiromichi Kanehiro Michiyoshi Hisanaga Yukio Aomatsu Saiho Ko Yukihiro Tatekawa Naoya Ikeda Hideki Kanokogi Yasuyuki Urizono Tsunehiro Kobayashi Takamune Shibaji Tetsuhiro Kanamura Sanehito Ogawa Hiroshige Nakano | 2000 | Hepatology2000，，： | 1 |
| 5 | Relevance of ADAMTS13 to liver transplantation and surgery显示文摘A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13(ADAMTS13) specifically cleaves unusually-large von Willebrand factor(VWF) multimers under high shear stress,and down-regulates VWF function to form platelet thrombi.Deficiency of plasma ADAMTS13 activity induces a life-threatening systemic disease,termed thrombotic microangiopathy(TMA) including thrombotic thrombocytopenic purpura(TTP).Children with advanced biliary cirrhosis due to congenital biliary atresia sometimes showed pathological features of TMA,with a concomitant decrease of plasma ADAMTS13 activity.Disappearance of their clinical findings of TTP after successful liver transplantation suggested that the liver is a major organ producing plasma ADAMTS13.In situ hybridization analysis showed that ADAMTS13 was produced by hepatic stellate cells.Subsequently,it was found that ADADTS13 was not merely responsible to development of TMA and TTP,but also related to some kinds of liver dysfunction after liver transplantation.Ischemia-reperfusion injury and acute rejection in liver transplant recipients were often associated with marked decrease of ADAMTS13 and concomitant formation of unusually large VWF multimers without findings of TMA/TTP.The similar phenomenon was observed also in patients who underwent hepatectomy for liver tumors.Imbalance between ADAMTS13 and VWF in the hepatic sinusoid might cause liver damage due to microcirculatory disturbance.It can be called as 'local TTP like mechanism' which plays a crucial role in liver dysfunction after liver transplantation and surgery. | Saiho Ko Hisanao Chisuwa Masanori Matsumoto Yoshihiro Fujimura Eiji Okano Yoshiyuki Nakajima | 2015 | World Journal of Hepatology2015，7，13： | 0 |
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