|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer显示文摘AIM:To evaluate the prognostic significance of the lymphocyte to monocyte ratio(LMR) in patients with unresectable metastatic colorectal cancer who received palliative chemotherapy.METHODS:A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy,while posttreatment LMR values were measured eight weeks after the initiation of chemotherapy.RESULTS:The median pre-treatment LMR was 4.16(range:0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38,66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate(P = 0.0011). Moreover,patients who demonstrated low pre-treatment LMR and normalization after treatmentexhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR values.CONCLUSION:The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy. | Masatsune Shibutani Kiyoshi Maeda Hisashi Nagahara Hiroshi Ohtani Katsunobu Sakurai Sadaaki Yamazoe Kenjiro Kimura Takahiro Toyokawa Ryosuke Amano Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa | 2015 | World Journal of Gastroenterology2015，21，34： | 19 |
| 2 | Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma显示文摘AIM To elucidate the effect of expression of doublecortin and Ca M kinase-like-1(DCLK1) in patients with pancreatic ductal adenocarcinoma(PDAC). METHODS Tumor specimens were obtained from 136 patients with pancreatic cancer who had undergone resection without preoperative therapy between January 2000 and December 2013 at the Department of Surgical Oncology, Osaka City University. The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition(EMT) marker expression, and cancer stem cell(CSC) marker expression. Univariate and multivariate survival analyses were performed and we assessed the association between DCLK1 expression and clinicopathological factors, including the EMT marker and CSC marker.RESULTS In total, 48.5%(66/136) of the pancreatic cancer samples were positive for DCLK1. Patients with DCLK1-positive tumors had significantly shorter survival times than those with DCLK1-negative tumors(median, 18.7 mo vs 49.5 mo, respectively; P < 0.0001). Positive DCLK1 expression correlated with histological grade(P = 0.0290), preoperative CA19-9 level(P = 0.0060), epithelial cell adhesion molecule(Ep CAM) expression(P = 0.0235), and the triple-positive expression of CD44/CD24/Ep CAM(P = 0.0139). On univariate survival analysis, five factors were significantly associated with worse overall survival: histological grade of G2 to G4(P = 0.0091), high preoperative serum SPan-1 level(P = 0.0034), R1/2(P < 0.0001), positive expression of DCLK1(P < 0.0001) or CD44(P = 0.0245). On multivariate survival analysis, R1/2 [odds ratio(OR) = 2.019, 95% confidence interval(CI): 1.380-2.933; P = 0.0004] and positive DCLK1 expression(OR = 1.848, 95%CI: 1.2854-2.661; P = 0.0009) were independent prognostic factors. CONCLUSION DCLK1 expression was found to be an independent prognostic factor and it may play a crucial prognostic role by promoting acquisition of stemness. | Kohei Nishio Kenjiro Kimura Ryosuke Amano Bunzo Nakata Sadaaki Yamazoe Go Ohira Kotaro Miura Naoki Kametani Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa Masaichi Ohira | 2017 | World Journal of Gastroenterology2017，23，31： | 3 |
| 3 | Impact of laparoscopic liver resection for hepatocellular carcinoma with F4-liver cirrhosis显示文摘 | Akishige Kanazawa Tadashi Tsukamoto Sadatoshi Shimizu Shintaro Kodai Sadaaki Yamazoe Satoshi Yamamoto Shoji Kubo | 2013 | Surgical Endoscopy2013，，7： | 3 |
| 4 | Laparoscopic liver resection for treating recurrent hepatocellular carcinoma显示文摘 | Akishige Kanazawa Tadashi Tsukamoto Sadatoshi Shimizu Shintaro Kodai Satoshi Yamamoto Sadaaki Yamazoe Go Ohira Takayoshi Nakajima | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，5： | 3 |
| 5 | Measurement of tea leaves ingredients with visible and near infrared reflection spectra显示文摘 | Yuki Fukumoto Sadaaki Iibuchi Mayumi Saito | 2006 | Jpn J Food Eng2006，1，7： | 1 |
| 6 | 90% write power-saving SRAM using sensing-amplifying memory cell 显示文摘 | Kanda K Sadaaki H Sakura T | 2004 | Journal of Solid State Circuit2004，39，6： | 1 |
| 7 | Isolation ofantioxidative compounds from Brazilian propolis: 3, 4 -Dihydroxy-5 - prenylcinnam is acid, a novel potent antioxidant显示文摘 | HayashiKatsuhiro Komura Sadaaki Isaji Nofiko ct at | 1999 | Chemical and Pharmaceutical Bulletin Tokyo1999，47，11： | 1 |
| 8 | Quadratic Stablization of ILQ Servo Systems with Generalized Reference Inputs显示文摘 | Sadaaki Kunimatsu Takao Fujii Taro Tsuiino | 2003 | Trans of the Society of Instrument and Control Engineers2003，39，3： | 1 |
| 9 | Analysis and Synthesis of Model Reference ILQ Servo System with Tracking Robustness 显示文摘 | Sadaaki Kunimatsu Masakazu Fujii Takao Fujii | 2004 | Trans of the Institute of System Control and Information Engineers2004，17，3： | 1 |
| 10 | Osteoclast Responses to Lipopolysaccharide, Parathyroid Hormone and Bisphos- phonates in Neonatal Murine Calvaria Analyzed by Laser Scanning Confocal Microscopy 显示文摘 | Keiko S Sadaaki T Takaahi K | 2005 | Journal of Histochemis- try ~ Cytochemistry2005，53，12： | 1 |
| 11 | Information clustering based on fuzzy multisets 显示文摘 | Sadaaki Miyamoto | 2003 | Information Processing and Management2003，39，： | 1 |
| 12 | Overexpression of CyclinB1 in gastric cancer and its Clinicopathological significance:An immunohistological study显示文摘 | Mitsuhiro Yasuda Fumio Takesue Sadaaki Inutsuka | 2002 | J Cancer Res Clin Oncol2002，128，： | 1 |
| 13 | The molecular basis of innate immunity in the horseshoe crab显示文摘 | Sadaaki Iwanaga | 2002 | Current Opinion in Immunology2002，，1： | 1 |
| 14 | Isolation ofantioxidative compounds from Brazilian propolis, 3,4-Dihydroxy-5-prenylcinnam is acid, a novel potent antioxidant显示文摘 | HayashiKatsuhiro Komura Sadaaki IsajiNoriko | 1999 | Chemical and Pharmaceutical Bulletin Tokyo1999，47，11： | 1 |
| 15 | Morphologic differences of the vascular buds in the vertebral endplate:scanning electron microsopic study 显示文摘 | Sadaaki Oki S Matsuda Y and Shibata T | 1996 | Spine1996，21，2： | 1 |
| 16 | Role of autologous blood transfusion in sacral tumor resection: patient selection and recovery after surgery and blood donation显示文摘 | Sadaaki Nakai Hidezo Yoshizawa Shigeru Kobayashi Kumi Naga Hirofusa Ichinose | 2000 | Journal of Orthopaedic Science2000，，4： | 1 |
| 17 | Immunohistochemical studies on oncogene products (c-erbB-2, EGFR, c-myc) and estrogen receptor in benign and malignant breast lesions显示文摘 | Katsunori Tauchi Sadaaki Hori Hitoshi Itoh R. Yoshiyuki Osamura Yutaka Tokuda Tomoo Tajima | 1989 | Virchows Archiv A Pathological Anatomy and Histopathology1989，，1： | 1 |
| 18 | Different Objective Functions in Fuzzy c-Means Algorithms and Kernel-Based Clustering显示文摘 | Miyamoto Sadaaki | 2011 | In- ternational Journal of Fuzzy Systems2011，13，2： | 1 |
| 19 | 90% write power-saving SRAM using sense-amplifying memory cell显示文摘 | Kanda K Sadaaki H Sakurai T | 2004 | IEEE J Sol Sta Circ2004，31，6： | 1 |
| 20 | Fuzzy c-means algorithms for data with tolerance based on opposite criterions 显示文摘 | Yuchi KANZAWA Yasunori ENDO Sadaaki MIYAMOTO | 2007 | IEICE Transactions on Fundamentals of Electronics Communications and Computer Science2007，90，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员