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| 1 | Hepatitis B virus genotypes and extrahepatic manifestations显示文摘 | Patrice Cacoub David Saadoun Marc Bourlière Hacene Khiri Agnes Martineau Yves Benhamou Marina Varastet Stanislas Pol Vincent Thibault Michel Rotily Philippe Halfon | 2005 | Journal of Hepatology2005，，5： | 5 |
| 2 | Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C显示文摘We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-α) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α treatment with ophthalmological monitoring if any ocular manifestation occurs. | Damien Sène Valérie Touitou Bahram Bodaghi David Saadoun Gabriel Perlemuter Nathalie Cassoux Jean-Charles Piette Phuc Le Hoang Patrice Cacoub | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 3 | Water movements in the brain: role of aquaporins显示文摘 | Matthew J. Tait Samira Saadoun B. Anthony Bell Marios C. Papadopoulos | 2007 | Trends in Neurosciences2007，，1： | 3 |
| 4 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 5 | Mixed structures as a new strategy to develop outstanding oxides-based cathode materials for sodium ion batteries: A review显示文摘Sodium ion batteries(SIBs)are an exciting alternative for post-lithium energy storage.They can be regarded as a promising and cost-efficient solution for grid applications as they exhibit similar’rocking chair’mechanism as lithium ion batteries,in addition to the abundance and low cost of sodium resources.Indeed,electrode materials,electrolytes,separators and smart design strategies are under spot and researchers are competing to come up with the ideal battery.Layered oxides with mixed structures are regarded as new concept that can offer a set of desired structural and energetic properties and are an attractive choice for next generation sodium ion batteries.However,unlocking this system chemistry,kinetics and reliable understanding of the intercalation/deintercalation mechanism upon electrochemical cycling is quite challenging.This review,through the examination of literature,gives a brief summary of the research progress and recent advances in the investigation of electrode materials based on layered oxides with mixed structures for sodium ion batteries.This new strategy leads in fact to positive electrodes with enhanced energetic performance as they consist of a combination of the energetic or/and structural properties of the existing structures. | Charifa Hakim Noha Sabi Ismael Saadoune | 2021 | Journal of Energy Chemistry2021，30，10： | 2 |
| 6 | Water movements in the brain: role of aquaporins显示文摘 | Matthew J. Tait Samira Saadoun B. Anthony Bell Marios C. Papadopoulos | 2007 | Trends in Neurosciences2007，，1： | 2 |
| 7 | Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption显示文摘 | SAADOUN S PAPADOPOULOS MC HARA-CHIKUMA M | 2005 | Nature2005，434，7034： | 1 |
| 8 | Impairment of angiogenesis and cell migration by targetedaquaporin-1 gene disruption显示文摘 | Saadoun S Papadopoulos MC Hara-Chikuma M | 2005 | Nature2005，434，7034： | 1 |
| 9 | The pathophysiology of HCV induced B-cell elonal disorders显示文摘 | Landau DA Saadoun D Calabrese LH | | 0，，06： | 1 |
| 10 | Dangers of bone graft substitutes: lessons from using GeneX 显示文摘 | Saadoun S Macdonald C Bell BA | 2011 | J Neurol Neurosurg Psychiatry2011，82，8： | 1 |
| 11 | An 8-year compilation of clinical results obtained with Steri-Oss endosseous implants显示文摘 | Saadoun AP Le Gall MG | 1996 | Compend Contin Educ Dent1996，17，6： | 1 |
| 12 | Impairment of angiogenesis and cell migration by targeted aquaporln-l gene dlsruptlon显示文摘 | Saadoun S Papadopoulos MC Hara?Chikuma M | 2005 | Nature2005，434，7034： | 1 |
| 13 | Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage显示文摘 | TAIT M J SAADOUN S BELL B A etal | 2010 | Neuroscience2010，167，1： | 1 |
| 14 | Increased aquaporin 1 water channel expression in human brain tumours 显示文摘 | Saadoun S Papadopoulos MC Davies DC | 2002 | Br J Cancer2002，87，6： | 1 |
| 15 | Neutrophil proteas inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain显示文摘 | Saadoun S Waters P MacDonald C | 2012 | Ann Neurol2012，71，3： | 1 |
| 16 | Selenium, copper, zinc, iron and manganese content of seven meat cuts from Hereford and Braford steers fed pas ture in Uruguay 显示文摘 | Cabrera M C Ramos A Saadoun A | 2010 | Meat Science2010，84，3： | 1 |
| 17 | In vivo lipogenesis of genetically lean and fat chickens : effects of nutritional state and dietary fat 显示文摘 | Saadoun A Leclercq B | 1987 | J Nutr1987，117，3： | 1 |
| 18 | Impairment of angiogenesis and cell migration by targeted aquaporin- 1 gene disruption 显示文摘 | Saadoun S Papadoboulos M C Hara-Chikuma M | 2005 | Nature2005，434，7034： | 1 |
| 19 | Impairment of angiogenesis and cell migration by targeted aquaporin 1 gene disruption显示文摘 | Saadoun S Papadopoulos MCI Hara-chikuma M | 2005 | Nature2005，434，： | 1 |
| 20 | Emerging molecular mechanisms of brain tumour oedema显示文摘 | Papadopoulos MC Saadoun S Davies DC | 2001 | Brit J Neurosurg2001，15，： | 1 |
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