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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies:results in 123 patients显示文摘 | Curley SA Izzo F Delrio P | | 0，，： | 3 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 5 | Radiofiequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 2 |
| 6 | Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 2 |
| 7 | Multimodality therapy for stage Ⅲ non-small-cell lung cancer显示文摘 | Daniel F Nena M Kathy SA | 2005 | J Clin Oncol2005，23，14： | 1 |
| 8 | Embryotoxic and long-term effects of cadmium exposure during embryogenesis in rats显示文摘 | SALVATORI F TALASSI CB SALZGEBEK SA | 2004 | Neurotoxicol Teratol2004，26，： | 1 |
| 9 | Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application : preparation and characterization 显示文摘 | LAI F WISSING SA MULLER RH | 2006 | AAPS Pharm Sci Tech2006，7，1： | 1 |
| 10 | Radiofrequency ablation of unre- sectable primary and metastatic hepatic malignancies: results in 123 patienrs显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 1 |
| 11 | Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 1 |
| 12 | , Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8 显示文摘 | Bigonnesse F Levesque SA Kukulski F | 2004 | Biochemistry2004，43，： | 1 |
| 13 | Surgical treatment of colorectal cancer metastasis显示文摘 | Curley SA Izzo F Abdalla E | 2004 | Cancer Metastasis Rev2004，23，12： | 1 |
| 14 | Development of an enzyme-linked immunosorbent assay for determination of the miticide bromopropylate显示文摘 | RAMON-AZCON J SA NCHEZ-BAFZA F SANVICENSN | 2009 | Journal of Agricultural and Food Chemistry2009，57，： | 1 |
| 15 | Determination of the fatty acid composition of saponified vegetable oils using matrix-assisted laser dcsorption/ionization time-of-flight mass spectrometry显示文摘 | AYORINDE F O GARVIN K SAED K | 2000 | Rapid Commun Mass Spectrum2000，14，： | 1 |
| 16 | Radiofrequency ablation of unresectableprimary and metastatic hepatic malignancies:results in 123 patients显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 1 |
| 17 | Macrophage migration inhibitory factor in prostatic adenocarcinoma:correlation with tumor grading and combination endocrine treatment-related changes显示文摘 | del Vecchio MT Tripodi SA Arcuri F Pergola L Hako L Vatti R | 2000 | Prostate2000，45，1： | 1 |
| 18 | A myosin phosphatase targeting subunit isoform transition defines a smooth muscle developmental phenotypic switch显示文摘 | Dirksen WP Vladic F Fisher SA | 2000 | Am J Physiol2000，278，： | 1 |
| 19 | Cardiovascular safety of the cy- elooxygenase-2 selective inhibitors pareeoxib and valdecoxib in the postoperative setting:an analysis of integrated data显示文摘 | Sehug SA Joshi GP Camu F | 2009 | Auesth Analg2009，108，1： | 1 |
| 20 | clinical review:critical care management of spontaneous intracerebral hemorrhage显示文摘 | Rincon F Mayer SA | 2008 | Crit Care2008，12，23： | 1 |
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