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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Performance in Luna's fist-edge-palm test according to educational Ievel显示文摘 | Nitrini R Caramelli P Herrera E Jr | 2005 | Cogn Behav Neurol2005，18，4： | 1 |
| 3 | Performance of peripheral(serum and molecular) blood markers for diagnosis of endometriosis显示文摘 | Mabrouk M Elmakky A Caramelli E | 2012 | Arch Gynecol Obstet2012，285，5： | 1 |
| 4 | Epidemiologic survey of dementia in a community-dwelling Brazilian population显示文摘 | Herrera E Jr Caramelli P Silveira AS | 2002 | Alzheimer Dis Assoc Disord2002，16，2： | 1 |
| 5 | Performance of peripheral(serum and molecular)blood markers for diagnosis of endometriosis显示文摘 | Mabrouk M Elmakky A Caramelli E | 2012 | Arch Gynecol Obstet2012，285，： | 1 |
| 6 | Effects of galantamine on attention and memory in Alzheimer' s disease measured by computerized neuropsychological tests:results of the Brazilian Multi-Center Galantamine Study (GAL-BRA -01)显示文摘 | Caramelli P Chaves ML Engelhardt E | 2004 | Arq Neuropsiquiatr2004，62，2： | 1 |
| 7 | Testing normality of fetal DNA concentration in maternal plasma at 10-12completed week's gestation:a preliminary approach to a new marker for genetic screening显示文摘 | Farina A Caramelli E Concu M | 2002 | Prenat Diagn2002，22，： | 1 |
| 8 | Testing normality of fetal DNA concentration in nmtemal plasnm at 10 -12 completed week's gestation: a preliminary approach to a new marker for genetic screening显示文摘 | Farina A Caramelli E Concu M | 2002 | Prenat Diagn2002，22，： | 1 |
| 9 | Mortality from dementia in a community-dwelling Brazilian population 显示文摘 | Nitrini R Caramelli P Herfera E Jr | 2005 | Int J Geriatr Psych2005，20，3： | 1 |
| 10 | Cell-free fetal DNA concentration in plasma of patients with abnormal uterine artery Doppler waveform and intrauterine growth restriction-a pilot study显示文摘 | Caramelli E Rizzo N Concu M | 2003 | Prenat Diagn2003，23，5： | 1 |
| 11 | Performance in Luria's fist-edge-palm test according to educational level显示文摘 | Nitrini R Caramelli P Herrera E Jr | 2005 | Cogn Behav Neurol2005，18，4： | 1 |
| 12 | Epidemiologic survey of dementia in a community-dwelling Brazilian population 显示文摘 | Herrera E Jr Caramelli P Nitrini R | 2002 | Alzheimer Dis Assoc Disord2002，16，2： | 1 |
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