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| 1 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
| 2 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 3 | Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating fact or gene in intramuscular DNA immunization显示文摘 | Cho J H Lee S W Sung Y C | 1999 | Vaccine1999，17，910： | 2 |
| 4 | Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte-macrophage-colony stimulating factor gene显示文摘 | Lee S W Cho J H Sung Y C | 1998 | J Virol1998，72，10： | 2 |
| 5 | A study on comparison of optimization performances between immune algorithm and other heuristic algorithms 显示文摘 | Sung C J Jang Hyun Kyo Hahn Song Yop | 1998 | IEEE Trans on Magnetics1998，34，5： | 2 |
| 6 | 显示文摘 | Sung H M Chen C J Ko W S | 1994 | IEEE Trans Magn1994，30，6： | 1 |
| 7 | Phenoloxidase activity of hemocytes derived from Penaeus monodon and Macrobrachium rosenbergii显示文摘 | SUNG H H CHANG H J HER C H | 1998 | J Invert Pathol1998，71，： | 1 |
| 8 | Cellular differentiation regulated by gibberellin in the Arabidopsis thaliana picklemutant显示文摘 | Ogas J Cheng J C Sung Z R | 1997 | Science1997，277，： | 1 |
| 9 | Systematic review of the epidemiologyof complicated peptic ulcer disease : incidence, recurrence, riskfactors and mortality显示文摘 | Lau JY Sung J Hill C | 2011 | Digestion2011，84，13： | 1 |
| 10 | Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province,Korea显示文摘 | Ok Y S Kim S C Kim K R Lee S S Moon D H Lim K J Sung J K Hur S O Yang J E | | 0，，： | 1 |
| 11 | Gold-coated iron nanoparticles:a novel magnetic resonance agent for T1 and T2 weighted imaging显示文摘 | SUNG J C BENJAMIN R J ANGELIQUE Y L | 2006 | Nanotechnology2006，17，3： | 1 |
| 12 | Effects of lamivudine on disease progression and development of liver cancer in advanced chronic hepatitis B:a prospective double-blined placebocontrolled trial显示文摘 | Liaw Y F Sung J J Y Chow W C | 2003 | Hepatology2003，，： | 1 |
| 13 | Crystal morphology control of AFI type molecular sieves with microwave irradi- ation显示文摘 | SUNG H J JONG S C | 2004 | J Mater Chem2004，14，： | 1 |
| 14 | Adaptive bit- interleaved coded OFDM with reduced feedback in- formation 显示文摘 | SUNG C K CHUNG S Y HEO J | 2007 | IEEE Transaction on Communication2007，55，9： | 1 |
| 15 | Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality显示文摘 | Lau JY Sung J Hill C | | Digestion0，84，2： | 1 |
| 16 | NERBio: using selected word conjunctions, term normalization, and global patterns to improve biomedical named entity recognition 显示文摘 | TSAI R T SUNG C L DAI H J | 2006 | BMC Bioinformatics2006，7，5： | 1 |
| 17 | Lamivudine for patients with chronic hepatitis B and advanced liver disease显示文摘 | Lhw Y F Sung J J Chow W C | 2004 | NEngl J Med2004，351，15： | 1 |
| 18 | Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease 显示文摘 | Liaw Y F Sung J J Chow W C | 2004 | N Engl J Med2004，351，15： | 1 |
| 19 | Serum alpha-fetoprotein in the early stage of human hepat-cellular carcinoma显示文摘 | Che D S Sung J L Shen J C | 1984 | Gastroenterology1984，86，1： | 1 |
| 20 | A predictive model for the level of sIgA based on IgG levels following the oral administration expressed in Saeehromyces cerevisiae显示文摘 | Sung J Seung W S Wun J C | 2005 | J Vet Sci2005，6，4： | 1 |
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