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| 1 | The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells显示文摘The herbal medicine Tong Luo Jiu Nao(TLJN)contains geniposide(GP)and ginsenoside Rg1 at a molar ratio of 10:1.Rg1 is the major component of another herbal medicine,panax notoginseng saponin(PNS).TLJN has been shown to strengthen brain function in humans,and in animals it improves learning and memory.We have previously shown that TLJN reduces amyloidogenic processing in Alzheimer’s disease(AD)mouse models.Together this suggests TLJN may be a potential treatment for patients with dementia.Because chronic damage of the central nervous system by formaldehyde(FA)has been presented as a risk factor for age-associated cognitive dysfunction,in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA.FA-exposed murine N2a neuroblastoma cells were incubated with TLJN,its main ingredient GP,as well as PNS,to measure cell viability and morphology,the rate of apoptosis and expression of genes encoding Akt,FOXO3,Bcl2 and p53.The CCK-8 assay,cytoskeletal staining and flow cytometry were used to test cell viability,morphology and apoptosis,respectively.Fluorescent quantitative real-time PCR(qRT-PCR)was used to monitor changes in gene expression,and HPLC to determine the rate of FA clearance.Treatment of N2a cells with 0.09 mmol L?1 FA for 24 h significantly reduced cell viability,changed cell morphology and promoted apoptosis.Both TLJN and GP conferred neuroprotection to FA-treated N2a cells,whereas PNS,which had to be used at lower concentrations because of its toxicity,did not.Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient,GP,has a major role in this efficacy.This presents purified GP as a drug or lead compound for the treatment of AD. | CHEN JinYan SUN MengRu WANG XingHua LU Jing WEI Yan TAN Yan LIU Ying GTZ Jürgen HE RongQiao HUA Qian | 2014 | Science China(Life Sciences)2014，57，4： | 15 |
| 2 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 3 | Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats显示文摘 | Yang Y Liu X Long Y Wang F Ding JH Liu SY Sun YH Yao HH Wang H Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 4 |
| 4 | Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats显示文摘 | Wang S Hu LF Zhang Y Sun T Sun YH Liu SY Ding JH Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 5 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 6 | Volatile flavor constituents in roasted pork of mini-pig显示文摘 | XIE J C SUN B G ZHENG F P | 2008 | Food Chemistry2008，109，： | 1 |
| 7 | Laser(Nd:YAG) Cladding of AZ91D Magnesium Alloys with Al +Si + Al2O3显示文摘 | Yao J Sun G P Wang H Y | 2006 | Journel of Alloys and Compounds2006，407，： | 1 |
| 8 | The structure and reactivity of coprecipitated Co-ZrO2 catalysts for Fischer-Tropsch synthesis显示文摘 | CHEN J G SUN Y H | 2004 | Stud Surf Sci Catal2004，147，： | 1 |
| 9 | Electrochemical adsorption behaviour of platinum stepped surfaces in sulphuric acid solutions 显示文摘 | Clavilier J Armand D Sun S G | 1986 | J Electroanal Chem1986，205，12： | 1 |
| 10 | Structured backward errors for KKT systems显示文摘 | SUN J G | 1999 | Linear Algebra and Its Applications1999，288，1： | 1 |
| 11 | Monodispersed colloidal spheres for uniform Y2O3:Eu^3+ red-phosphor particles and greatly enhanced lumi- nescence by simultaneous Gd^3+ doping 显示文摘 | LI J G LI X D SUN X D | 2008 | J Phys Chem C2008，112，11： | 1 |
| 12 | Fabrication and application of nearfield optical fiber probe显示文摘 | Sun J L Xu J H Tian G Y | 2001 | Chinese Physics2001，10，7： | 1 |
| 13 | Residual Stress in Silicon Carbide Particulate Reinforced Aluminum Composites显示文摘 | SUN Z M LI J B WANG Z G LI W J | 1992 | Acta Metall Mater1992，40，11： | 1 |
| 14 | Growth of(100) -oriented LaNiO3 thin films directly on Si substrates by a simple metalorganic decomposition technique for the highly oriented PZT thin films显示文摘 | Meng X J Cheng J G Sun J L | 2000 | J Cryst Growth2000，220，： | 1 |
| 15 | Global exponential stabilization for a class of uncertain nonlinear systems with control constraint显示文摘 | Sun Y J Lien C H Hsieh J G | 1998 | IEEE Trans on AC1998，43，5： | 1 |
| 16 | Treatment of hyperlipidemia with a modified low density lipoprotein apheresis system with dextran sulfate 显示文摘 | ZHAO Y H ZOU Y G SUN Q J | 2007 | Ther Apher Dial2007，11，4： | 1 |
| 17 | 显示文摘 | Sun G Z Chen X G Zhang J | 2010 | Water Sci Technol2010，61，： | 1 |
| 18 | 查看详情显示文摘 | J R Sun F X Hu B G Shen | | 0，，： | 1 |
| 19 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 20 | Changes in mRNA levels for group I metabototropec glutamate receptors following in utero hypoxiaischemia显示文摘 | Simonyi A J Sun G Y | 1999 | Brain Res Dev1999，112，1： | 1 |
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