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| 1 | Systematic review of novel ablative methods in locally advanced pancreatic cancer显示文摘Unresectable locally advanced pancreatic cancer with or without metastatic disease is associated with a very poor prognosis.Current standard therapy is limited to chemotherapy or chemoradiotherapy.Few regimens have been shown to have a substantial survival advantage and novel treatment strategies are urgently needed.Thermal and laser based ablative techniques are widely used in many solid organ malignancies.Initial studies in the pancreas were associated with significant morbidity and mortality,which limited widespread adoption.Modifications to the various applications,in particular combining the techniques with high quality imaging such as computed tomography and intraoperative or endoscopic ultrasound has enabled real time treatment monitoring and significant improvements in safety.We conducted a systematic review of the litera-ture up to October 2013.Initial studies suggest that ablative therapies may confer an additional survival benefit over best supportive care but randomised studies are required to validate these findings. | Margaret G Keane Konstantinos Bramis Stephen P Pereira Giuseppe K Fusai | 2014 | World Journal of Gastroenterology2014，20，9： | 30 |
| 2 | Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation显示文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation. | Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles H Scudamore Andrzej K Buczkowski Eric M Yoshida | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 5 | Fractures of the calcaneus显示文摘 | DAVID P BRUCE J STEPHEN K | 2002 | Orthop Clin North(Am)2002，33，1： | 1 |
| 6 | Inference of population structure using multilocus genotype data 显示文摘 | Pritchard J K Stephens M Donnelly P | 2000 | Genetics2000，155，： | 1 |
| 7 | Inference of population structure using muhilocus genotype data显示文摘 | Pritchard J K Stephens M Donnelly P | 2000 | Genetics2000，155，2： | 1 |
| 8 | Association mapping in structured populations 显示文摘 | Pritchard J K Stephens M Rosenberg N A DonneUy P | 2000 | The American Journal of Human Genetics2000，67，1： | 1 |
| 9 | Field test for ground thermal properties-methods and impact on ground source heat pump design显示文摘 | Stephen P K | 2000 | ASHRAE Trans2000，25，4： | 1 |
| 10 | Field tests for ground thermal properties methods and impact on ground-source heat pump design 显示文摘 | STEPHEN P K | 1992 | ASHRAE Transactions1992，，1： | 1 |
| 11 | The role of neuropeptide Y in the antiobesity action of the obese gene product显示文摘 | Stephens T W Basinski M Bristow P K | 1995 | Nature1995，377，6549： | 1 |
| 12 | Secreted enzymes of Aernomonas显示文摘 | John M P Stephen P K Radamin S | 1997 | PPMS Microbiol1997，15，： | 1 |
| 13 | Hypertension effect of polyunsaturated dietary fat显示文摘 | Laryssa N K Mary M P Stephen M S | 1994 | Metabolism1994，43，： | 1 |
| 14 | The role of neu ropeptide Y in the antiobesity action of the obese gene product显示文摘 | Stephens T W Basinski Bristow P K | 1995 | Nature (Lond)1995，377，： | 1 |
| 15 | Inference of population structure using multilocus genotype data显示文摘 | Pritchard J K Stephens M Donnelly P | 2000 | Genetics2000，155，： | 1 |
| 16 | The use of an automated growth analyser to measure recovery times of single heat-injured Salmonella cells 显示文摘 | Stephens P J Joynson J A Davies K W | 1997 | Journal of Applied Microbiology1997，83，4： | 1 |
| 17 | Consistency of hemodynamic responses to cold stress in adolescents显示文摘 | Stephen M P Marie B | 2000 | Hypertension2000，36，： | 1 |
| 18 | Cyclic and static laboratory tests on Drammen clay 显示文摘 | Andersen K H Jacobus H P Stephen F B and Wim F R | 1980 | Journal of Geotechnical engineering Division1980，106，5： | 1 |
| 19 | Inference of population structure using multilocus genotype data 显示文摘 | Pritchard J K Stephens M Donnelly P | 2000 | Genetics2000，155，： | 1 |
| 20 | Inference of population structure using muhilocus genotype data显示文摘 | PRITCHARD J K STEPHENS M DONNELLY P | 2000 | Genetics2000，155，2： | 1 |
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