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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Antioxidant Effect of a Novel Class of Telluroacetilene Compounds:studies in Vitro and in Vivo显示文摘 | A C G Souza C Luchese J S Santos Neto | 2009 | Life Science2009，84，1112： | 1 |
| 3 | Supply chain coordination for false failure returns显示文摘 | Ferguson M Guide V D R Souza G C | 2006 | Manufacturing & Service Operations Management2006，8，4： | 1 |
| 4 | Mesoporous silica-magnetite nanocomposite synthesized by using a neutral surfactant显示文摘 | Souza K C Salazar-Alvarez G Ardisson J D Macedo W A A Sousa E M B | 2008 | Nanotechnology2008，19，18： | 1 |
| 5 | A Hybrid Particle Swarm Optimization Applied to Loss Power Minimization显示文摘 | Esmin A A A Lambert-Torres G Zambroni de Souza A C | 2005 | IEEE Transaction Power Systems2005，20，2： | 1 |
| 6 | In-house method validation: Application in arsenic analysis显示文摘 | de Souza S V C Pinto C T Junqueira R G | 2007 | Food Composition and Analysis2007，20，34： | 1 |
| 7 | Comparative study of methylene blue and erythrosine dyes employed in photodynam- ic therapy for inactivation of planktonic and biofilm-cultivated Aggregatibacter actinomycetemcomitans 显示文摘 | Goulart Rde C Thedei G Jr Souza SL | 2010 | Photomed Laser Surg2010，281，： | 1 |
| 8 | Esterase enzymes involved in pyrethroid and organophosphate resistance in a Brazilian population of Riphicephalltts (Boophilus) microplus(Aeari, Ixodidae) 显示文摘 | Baffi M A Souza G R L Sousa C S | 2008 | Molecular & Biochemical Parasitology2008，160，： | 1 |
| 9 | Validation of a matrix solid phase dispersion (MSPD) technique for determination of pesticides in lyophilized eggs of the chicken Gallus gallus domesticus显示文摘 | dos Reis Souza M K Moreira C O de Lima T G | 2013 | Microchem J2013，110，： | 1 |
| 10 | Note: An application of the EOQ model with nonlinear holding cost to i ventory management of perishables显示文摘 | FERGUSON M JAYARAMAN V SOUZA G C | 2007 | European Journal of Op erational Research2007，，1： | 1 |
| 11 | The σ phase formation in annealed UNS S31803 duplex stainless steel: Texture aspects显示文摘 | Souza C M Abreu H F G Tavares S S M | 2008 | Materials Characterization2008，59，9： | 1 |
| 12 | Genotypic stability and adaptability in tropical maize based on AMMI and GGE biplot analysis 显示文摘 | BALESTRE M VON PINHO R G SOUZA J C | 2009 | Genetics and Molecular Research2009，8，4： | 1 |
| 13 | ICP OES simultaneous determination of Ca, Cu, Fe, Mg, Mn, Na, and P inbiodiesel by axial and radial inductively coupled plasma-optical emission spectrometry显示文摘 | de SOUZA R M LEOCADIO L G da SILVEIRA C L P | 2008 | Analytical Letter2008，41，9： | 1 |
| 14 | Antioxidant ac- tivity and total phenolic content of Agaricus brasiliensis ( Agari- cus blazei Murril) in two stages of maturity 显示文摘 | Soares A A Souza C G M Daniel F M | 2009 | Food Chemis- try2009，112，4： | 1 |
| 15 | Joint dynamicsmodeling and parameter identification for space robotapplications 显示文摘 | Da Silva A R De Souza L C G Schafer B | 2007 | Mathematical Problems in Engineering2007，1，10： | 1 |
| 16 | Managing product rollovers显示文摘 | Koca E Souza G C Druehl C T | 2010 | Decision Sciences2010，41，2： | 1 |
| 17 | Effect of heatingand cooling on rheological parameters of edible vegetable oils显示文摘 | SANTOS J C O SANTOS I M G SOUZA A G | 2005 | Journalof Food Engineering2005，67，4： | 1 |
| 18 | Supply chain coordination for false failure returns显示文摘 | Ferguson M Guide Jr G C Souza | | 0，，04： | 1 |
| 19 | MunozBiotechnologies for greenhouse gases (CH4, N2O, and CO2) abatement: state of the art and challenges显示文摘 | Lopez J C Quijano G Souza Theo S O | 2013 | Applied Mierobiol Biotechnology2013，97，： | 1 |
| 20 | The levels o1 IL-17A and ofthe cytokines involved in Th17 cell commitment are increased inpatients with chronic immune thrombocytopenia显示文摘 | Rocha AM Souza C Rocha G A | 2011 | Haematologi-ca2011，96，10： | 1 |
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