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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents显示文摘Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipo- philic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff bases were synthe- sized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)ben- zylideneaminonaphthothiazole was converted to its Co(II), Ni(II) and Cu(II) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bac- teria. The minimum inhibitory concentrations of all the Schiff bases and metal complexes were determined by agar streak dilution method. Results: All the compounds moderately inhibited the growth of Gram positive and Gram negative bacteria. In the present study among all Schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(II) metal complex was found to be most potent. Conclusion: The results obtained validate the hypothesis that Schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the Schiff bases. | AZAM Faizul SINGH Satendra KHOKHRA Sukhbir Lal PRAKASH Om | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，6： | 4 |
| 3 | Multiple facets of poly(ADP-ribose) polymerase-1 in neurological diseases显示文摘The highly conserved abundant nuclear protein poly(ADP-ribose)polymerase-1(PARP-1)is activated by DNA damage.PARP-1 activation is associated in DNA repair,cell death and inflammation.Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases,the attention towards PARP-1 as a | Chandra Shaker Sriram Ashok Jangra Rajaram Mohanrao Madhana Satendra Singh Gurjar Pritam Mohan Babul Kumar Bezbaruah | 2015 | Neural Regeneration Research2015，10，1： | 1 |
| 4 | The role of miRNA in inflammation and autoimmunity显示文摘 | Ram Pyare Singh Israel Massachi Sudhir Manickavel Satendra Singh Nagesh P. Rao Sascha Hasan Deborah K. Mc Curdy Sherven Sharma David Wong Bevra H. Hahn Hamida Rehimi | 2013 | Autoimmunity Reviews2013，，： | 1 |
| 5 | Hepatic endogenous defense potential of propolis after mercury intoxication显示文摘Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LPO)and oxidized glutathione(GSSG)levels,decreased the level of reduced glu-tathione(GSH)and various antioxidant enzymes in liver and also increased the activities of liver marker enzymes in serum.Therapy with propolis extract,a resinous wax-like beehive product(200 mg kg–1 orally,after mercury administration),for 3 days inhibited LPO and the formation of GSSG and increased the level of GSH in the liver.Release of serum transaminases,alkaline phosphatase,lactate dehydrogenase and-glutamyl transpeptidase were significantly restored after propolis treatment.The activities of antioxidant enzymes,that is,superoxide dismutase,catalase,glutathione-S-transferase and glucose-6-phosphate dehydrogenase,were also concomitantly restored towards normal levels after propolis administration.These observations clearly demonstrate that propolis treatment augments antioxidant defense against mercury-induced toxicity and provide evidence that propolis has therapeutic potential as a hepatoprotective agent. | Monika BHADAURIA Sangeeta SHUKLA Ramesh MATHUR Om PAGRAWAL Sadhana SHRIVASTAVA Sonia JOHRI Deepmala JOSHI Varsha SINGH Deepak MITTAL Satendra Kumar NIRALA | 2008 | Integrative Zoology2008，3，4： | 0 |
| 6 | Cosmology using long gamma-ray bursts: statistical analysis of errors in calibrated data显示文摘We investigate direction dependence and non-Gaussian features in high-z cosmological data using ?_(χ~2) and ?_χ statistics and the Kolmogorov-Smirnov test. These techniques are applied on a set of calibrated long gamma-ray bursts(GRBs) and its combination with recent Type Ia supernovae data(Union2). Our statistical analysis shows a weak but consistent direction dependence in both the data sets.The analysis also indicates a non-Gaussian nature of errors in both data sets. | Meghendra Singh Shashikant Gupta Amit Sharma Satendra Sharma | 2019 | Research in Astronomy and Astrophysics2019，19，2： | 0 |
| 7 | Neutralizing possibilities of whole virion and mRNA vaccine triggered antibodies of Wuhan strain of SARS-CoV-2 with receptor binding domains of spike proteins of Delta and Omicron strains显示文摘Mutations in the receptor binding domain(RBD)of SARS-CoV-2 spike protein have given birth to the new variants of concern viz.Delta and Omicron strain.As we are using vaccines which are either mRNA of spike protein of Wuhan strain or its whole virion vaccine,these vaccines will trigger antibodies to be able to bind with the epitopes of spike protein of Wuhan strain.There appears a need to study whether vaccine generated circulating neutralizing antibodies in vaccinated people are able to neutralize the receptor binding domain of spike protein of currently circulating Delta and Omicron strains as well.We need to address this contention in two phases:first to undertake docking studies of vaccine generated antibodies with Wuhan,Delta and Omicron strains and second to conduct the wet lab studies and observe antigen-antibody bindings employing Immunofluorescence and Cryo-Electron Microscopic studies.The present paper reports results of docking studies using bioinformatic softwares to provide the baseline information for wet lab studies. | Shilpa Barthwal Bennet Angel Annette Angel Vinod Joshi BM Shareef Nuzhat M Peer Poorna Khaneja Ambreen S Khan Bhawna Sharma Neha Singh Ramesh Joshi Komal Tomar Kiran Yadav Satendra P Singh | 2023 | Asian Pacific Journal of Tropical Medicine2023，16，2： | 0 |
| 8 | sp^(2)碳用于3D打印技术综述:材料、性能和应用显示文摘3D打印可以改变现有的生产方法,是第四次工程革命中的一项现代技术。它从成型原理上提出了分层制造、逐层叠加成型的新颖生产方法,从根本上简化了制造工艺,实现了大规模定制生产。然而,这一新技术仍存在许多问题。除了纯石墨烯外,sp^(2)碳具有好的亲水性,3D打印难度较小。sp^(2)碳还可在3D打印中的各种阶段应用。纯石墨烯的疏水性使其难以在水系介质中打印和加工。毛细管油墨的发展使得纯石墨烯的3D打印成为可能。本文综述了sp^(2)碳的3D打印技术的最新进展。首先简要概述了3D打印技术,随后概述了sp^(2)碳的3D打印及其在各种方面的应用。最后,讨论了这一新领域的发展前景和机遇。 | Satendra Kumar Manoj Goswami Netrapal Singh Sathish Natarajan Surender Kumar | 2022 | 新型炭材料(中英文)2022，37，6： | 0 |
| 9 | 快速热处理化学气相沉积法制备用于电子产品热管理的轻质柔性石墨烯显示文摘下一代电子产品的飞速发展对热管理提出了更高的要求。初始石墨烯的导热性是铜的13倍。本文通过快速热处理化学气相沉积(RTP-CVD)法制备了具有大sp^(2)结构域的单层、双层和多层石墨烯(SLG、BLG、FLG),进一步通过低浓度H_(2)还原制备了高导热石墨烯。在1000℃下生长25 min制备出SLG,利用拉曼光谱和透射电子显微镜(TEM)研究了石墨烯的品质。为了验证RTP-CVD法生成的石墨烯的散热能力,将其作为2TB固态硬盘的散热器,通过红外热成像仪进行了研究。结果证明,RTP-CVD生长的石墨烯用于消费电子产品的热管理测试时性能表现优异。SLG显示温度(最高)比商用铜散热器低5℃,SLG的散热能力比商用铜散热器快200倍左右。综上,利用RTP-CVD法制备的轻质的柔性石墨烯可以成为下一代5G设备和消费电子产品热管理的更好选择。 | Satendra Kumar Manoj Goswami Netrapal Singh Uday Deshpande Surender Kumar N.Sathish | 2023 | 新型炭材料(中英文)2023，38，3： | 0 |
| 10 | On the non-Gaussian errors in high-z supernovae type Ia data显示文摘The nature of random errors in any data set is Gaussian, which is a well established fact according to the Central Limit Theorem. Supernovae type Ia data have played a crucial role in major discoveries in cosmology. Unlike in laboratory experiments, astronomical measurements cannot be performed in controlled situations. Thus, errors in astronomical data can be more severe in terms of systematics and non-Gaussianity compared to those of laboratory experiments. In this paper, we use the Kolmogorov-Smirnov statistic to test non-Gaussianity in high-z supernovae data. We apply this statistic to four data sets, i.e., Gold data(2004),Gold data(2007), the Union2 catalog and the Union2.1 data set for our analysis. Our results show that in all four data sets the errors are consistent with a Gaussian distribution. | Meghendra Singh Ashwini Pandey Amit Sharma Shashikant Gupta Satendra Sharma | 2016 | Research in Astronomy and Astrophysics2016，16，11： | 0 |
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