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| 1 | Simultaneous multiple time scale imaging for kHz-MHz high-speed accelerometry显示文摘Fast transient events,such as the disintegration of liquid bodies or chemical reactions between radical species,involve various processes that may occur at different time scales.Currently,there are two alternatives for monitoring such events:burst-or high-speed imaging.Burst imaging at ultrahigh speeds(~100 MHz to THz)allows for the capture of nature's fastest processes but only for a narrowly confined period of time and at a repetition rate of~10 Hz.Monitoring long lasting,rapidly evolving transient events requires a significantly higher repetition rate,which is met by existing~kHz to 1 MHz high-speed imaging technology.However,the use of such systems eliminates the possibility to observe dynamics occurring on the sub-microsecond time scale.In this paper,we present a solution to this technological gap by combining multiplexed imaging with high-speed sensor technology,resulting in temporally resolved,high-spatial-resolution image series at two simultaneous time scales.We further demonstrate how the collection of such data opens up the tracking of rapidly evolving structures up to MHz burst rates over long durations,allowing,for the first time,to our knowledge,the extraction of acceleration fields acting upon the liquid bodies of an atomizing spray in two dimensions at k Hz frame rates. | VASSILY KORNIENKO DAVID ANDERSSON MEHDI STITI JONAS RAVELID SIMON EK ANDREAS EHN EDOUARD BERROCAL ELIAS KRISTENSSON | 2022 | Photonics Research2022，10，7： | 1 |
| 2 | Colorectal neoplasia screen- ing before age 50? : current epidemiologic trends in the United States 显示文摘 | Cooley EK McPhee jT Simons JP | 2009 | Dis Colon Rectum2009，52，2： | 1 |
| 3 | Why plants need more than one type of auxin 显示文摘 | Simon S Pet~ek J | 2011 | Plant Sci2011，180，3： | 1 |
| 4 | Signal transduction and myeloma:New targets,new hope显示文摘 | Lonial S Waller EK Simons JW | 2003 | Cancer Biol Ther2003，2，4： | 1 |
| 5 | Why plants need more than one type of auxin显示文摘 | Simon S Petrá(s)ek J | 2011 | Plant Science2011，180，3： | 1 |
| 6 | Why plants need more than one type of auxin显示文摘 | Simon S Petrá?ek J | 2011 | Plant Sci2011，180，3： | 1 |
| 7 | Gender and tachycardia: independent modulation of platelet reactivity in patients with atrial fibrillation显示文摘有纤维性颤动(AF ) 经验增加了的 atrial 的 BackgroundFemale 病人与男性相比 thromboembolism 冒险,被它的包括在 CHA 2 DS 2 VASc 分数。新发作 AF (经常与心悸亢进联系了) 也讨论病人增加的 thromboembolic 风险。位于这风险下面的机制不明确,却新发作 AF 与血小板的深刻缺陷被联系氮的氧化物(没有) 发信号。给对 catecholamines 的心血管的回答是性依赖者,并且在新发作 AF 的心悸亢进的存在可以代表回答到 catecholaminergic 刺激,我们在血小板聚集上探索了性和心悸亢进的潜在的影响,没有 signalling.MethodsInteractions 在在导致的腺苷 diphosphate (自动数据处理)的程度之间的 87 个 AF 病人被寻求血小板聚集, anti-aggregatory NO 完成施主,钠 nitroprusside ,性,和承认 h 交往 thioredoxin 蛋白质(Txnip ) 的血小板表示的潜在的影响也是证实的协变性的 evaluated.ResultsAnalysis 在血小板自动数据处理和没有回答之间的生理的对抗的存在[F (1, 74 )= 12.212, P <0.01 ] 当女性相关与时没损害血小板 aggregability 的回答独立人士[F (2, 74 )= 8.313, P <0.01 ] 。承认心率与血小板聚集直接相关(r = 0.235, P <0.05 ) ,并且相反地没有反应(r =− 0.331, P <0.01 ) 。既不与性也不与心 rate.ConclusionsThese 改变的 Txnip 表示结果显示那性和心率是血小板功能的独立决定因素。正常血小板功能的恢复上的心悸亢进的颠倒的通常认为的利益的未来的研究因此是优先级。 | Nathan EK Procter Jocasta Ball Doan TM Ngo Jeffrey S Isenberg Elaine M Hylek Yuliy Y Chirkov Simon Stewart John D Horowitz | 2016 | Journal of Geriatric Cardiology2016，13，3： | 1 |
| 8 | Psychiatric disorders associated with disturbed sleep and circadian rhythms显示文摘 | Simon EK | 2009 | Encyclop Neurosci2009，，： | 1 |
| 9 | Factors influencing the failure of interferon-free therapy for chronic hepatitis C:Data from the Polish EpiTer-2 cohort study显示文摘BACKGROUND The introduction of direct-acting antiviral drugs into clinical practice has revolutionized the treatment of chronic hepatitis C,making it highly effective and safe for patients.However,few researchers have analyzed the factors causing therapy failure in some patients.AIM To analyze factors influencing the failure of direct antiviral drugs in the large,multicenter EpiTer-2 cohort in a real-world setting.METHODS The study cohort consisted of patients with chronic hepatitis C treated at 22 Polish centers from 2016-2020.Data collected from the online EpiTer-2 database included the following:hepatitis C virus(HCV)genotype,stage of fibrosis,hematology and liver function parameters,Child-Turcotte-Pugh and Model for End-stage Liver Disease scores,prior antiviral therapy,concomitant diseases,and drugs used in relation to hepatitis B virus(HBV)and/or human immunodeficiency virus(HIV)coinfections.Adverse events observed during the treatment and follow-up period were reported.Both standard and machine learning methods were used for statistical analysis.RESULTS During analysis,12614 patients with chronic hepatitis C were registered,of which 11938(mean age:52 years)had available sustained virologic response(SVR)data[11629(97%)achieved SVR and 309(3%)did not].Most patients(78.1%)were infected with HCV genotype 1b.Liver cirrhosis was diagnosed in 2974 patients,while advanced fibrosis(F3)was diagnosed in 1717 patients.We included patients with features of hepatic failure at baseline[ascites in 142(1.2%)and encephalopathy in 68(0.6%)patients].The most important host factors negatively influencing treatment efficacy were liver cirrhosis,clinical and laboratory features of liver failure,history of hepatocellular carcinoma,and higher body mass index.Among viral factors,genotype 3 and viral load also exerted an influence on treatment efficacy.Classical statistical analysis revealed that treatment ineffectiveness seemed to be influenced by the male sex,which was not confirmed by the multivariate analysis using the machine learning algorithm(random forest).Coinfection with HBV(including patients with on-treatment reactivation of HBV infection)or HIV,extrahepatic manifestations,and renal failure did not significantly affect the treatment efficacy.CONCLUSION In patients with advanced liver disease,individualized therapy(testing for resistance-associated variants and response-guided treatment)should be considered to maximize the chance of achieving SVR. | Ewa Janczewska Mateusz Franciszek Kołek Beata Lorenc Jakub Klapaczyński Magdalena Tudrujek-Zdunek Marek Sitko Włodzimierz Mazur Dorota Zarębska-Michaluk Iwona Buczyńska Dorota Dybowska Agnieszka Czauż-Andrzejuk Hanna Berak RafałKrygier Jerzy Jaroszewicz Jolanta Citko Anna Piekarska Beata Dobracka Łukasz Socha Zbigniew Deroń Łukasz Laurans Jolanta Białkowska-Warzecha Olga Tronina Brygida Adamek Krzysztof Tomasiewicz Krzysztof Simon Malgorzata Pawłowska Waldemar Halota Robert Flisiak | 2021 | World Journal of Gastroenterology2021，27，18： | 0 |
| 10 | Overview of Activities:ARES-III and LEARN Analog Missions in the LunAres Hab显示文摘Progress is being made on human Lunar and Martian missions by space agencies and private organisations around the world,with the aims of establishing reliable long-duration architectures.Complementing this,research is being carried out under controlled and isolated conditions within simulated space habitats,to gain insights into the effects of such conditions on the research subjects and their impacts on crews’wellbeing and success.This paper provides an overview of the experiments conducted during two separate 15-day missions—one Martian and one Lunar—conducted in the LunAres Research Base in Piła,Poland,in 2018.Some activities were common between the two crews;others were only carried out by one.Using the same methodology,both collected cognitive function,environmental,physiological,and inventory data,resulting in a larger dataset allowing comparisons between the two missions in terms of varying human factors.Experiments conducted by the Lunar crew included the following:effects of consuming lyophilised food on oral health and saliva production,influence of isolation on hearing capability,feelings on security in the isolated habitat,and research into earthworm growth in different soil compositions.The Mars mission analysed physical performances of the crew and compared them to performances realised during similar activities in Mars Research Desert Station missions and the impact of confinement on their efficiency performing a remote operation of a rover.For each piece of research,an overview of the background,methodology,results,and conclusions is given,referencing the resulting papers.In addition,nonresearch activities are included for completeness and context. | Simon Bouriat Matej Poliaček Jacob Smith | 2022 | Space(Science & Technology)2022，，1： | 0 |
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