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| 1 | Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins显示文摘Most mammalian cells take up cholesterol from low-density lipoproteins(LDLs) via receptor-mediated endocytosis.After reaching lysosomes,LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional needs.Peroxisomes are recently found to receive cholesterol from lysosomes through lysosomeperoxisome membrane contacts.However,whether and how cholesterol is conveyed from peroxisomes to the ER remain unknown.Here,by combining high-resolution microscopic analyses and in vitro reconstitution of highly purified organelles or artificial liposomes,we demonstrate that peroxisomes form membrane contacts with the ER through the interaction between peroxisomal PI(4,5)P2 and ER-resident extended synaptotagmin-1,2 and 3(E-Syts).Depletion of peroxisomal PI(4,5)P2 or ESyts markedly decreases peroxisome-ER membrane contacts and induces cholesterol accumulation in lysosomes.Furthermore,we show that cholesterol is delivered from 3H-labeled peroxisomes or PI(4,5)P2-containing liposomes to the ER in vitro,and that the presence of peroxisomes augments cholesterol transfer from lysosomes to the ER.Together,our study reveals a new cholesterol transport pathway along the lysosome-peroxisome-ER membrane contacts in the cell. | Jian Xiao Jie Luo Ao Hu Ting Xiao Meixin Li Zekai Kong Luyi Jiang Zimu Zhou Yacheng Liao Chang Xie Beibei Chu Honghua Miao Boliang Li Xiongjie Shi Bao-Liang Song | 2019 | Science China(Life Sciences)2019，62，9： | 8 |
| 2 | Assessment and regulation of ocean health based on ecosystem services: Case study in the Laizhou Bay, China显示文摘The ecosystem-based management of nearshore waters requires integrated assessment of ocean health and scientific guidance on artificial regulations to promote sustainable development. Quantitative approaches were developed in this paper to assess present and near-term ocean health based on ecosystem services. Results of the case study in the Laizhou Bay of China showed that the index score of ocean health was 0.785 6 out of 1.0 at present and was expected to range from 0.555 1 to 0.804 1 in the near-term future depending on different intensities of artificial regulation of negative pressures. Specifically, the results of ocean health at present mainly indicated that cultural services and provisioning services performed essentially perfectly while supporting services and regulating services functioned less well. It can be concluded that this nearshore ecosystem would partially lose supporting and regulating services in the near-term future if the increasing pressures were not wellregulated but that all of these categories of ecosystem services could be slightly improved if the negative pressures were fully controlled. Additionally, it is recommended that publicity and education on ecosystem services especially on cultural services and regulating services should be further strengthened. The analytical process and resulting quantification provide flexible tools to guide future development of regulations so as to facilitate ecosystem-based management in the coastal zone. | SHEN Chengcheng ZHENG Wei SHI Honghua DING Dewen WANG Zongling | 2015 | Acta Oceanologica Sinica2015，34，12： | 4 |
| 3 | A model to assess fundamental and realized carrying capacities of island ecosystem:A case study in the southern Miaodao Archipelago of China显示文摘Research on carrying capacity, aiming at maintaining the limited ability of the Earth's life supporting system to sustain human development, requires a comprehensive and ecosystem-based approach to monitor and assess the localized sustainability of coupled social and ecological systems. A definition termed the ecosystem-based carrying capacity of island(EBCCI) was developed in this paper of which the indices of fundamental and realized carrying capacities of island(FCCI and RCCI) were highlighted to emphasize the inter-dependencies between social systems and ecological systems. In order to avoid the difficulties and uncertainties of direct assessment, the related assessment model was established on the basis of synthetic evaluation of inherent and external factors affecting the EBCCI. The southern Miaodao Archipelago(SMA) located in the intersection of the Bohai Sea and the Yellow Sea, China, was taken as a typical example to acquire integrated recognition of the island ecosystem and its carrying capacity so as to discuss its sustainable development. The index scores of FCCI and RCCI in the SMA were 0.818 5 and 0.712 9 out of 1.0, respectively, with acceptable uncertainties. The results showed a relatively well capacity to sustain progress and relatively well realization of the carrying capacity of island ecosystem, owing to a well capacity of ecologically regulating, general performance of both ecologically supporting and resource provisioning, and a relatively high level of social supporting system. The study implied that it was critical to optimize the inter-dependencies and to sustain the relative balance between social systems and ecological systems so as to improve the RCCI and further facilitate the sustainability of SMA. The approach proposed in this paper provides a powerful tool which is well applicative to the regional level of an oceanic island or archipelago to study the sustainable development and can be further popularized to the coastal zone. | SHI Honghua SHEN Chengcheng ZHENG Wei LI Fen WANG Xiaoli CHI Yuan GUO Zhen QIAO Mingyang GAO Liyuan DING Dewen | 2016 | Acta Oceanologica Sinica2016，35，2： | 4 |
| 4 | Spatio-temporal variability of phytoplankton assemblages and its controlling factors in spring and summer in the Subei Shoal of Yellow Sea, China显示文摘The Subei Shoal is a special coastal area with complex physical oceanographic properties in the Yellow Sea.In the present study,the distribution of phytoplankton and its correlation with environmental factors were studied during spring and summer of 2012 in the Subei Shoal of the Yellow Sea.Phytoplankton species composition and abundance data were accomplished by Utermohl method.Diatoms represented the greatest cellular abundance during the study period.In spring,the phytoplankton cell abundance ranged from 1.59×10^3 to 269.78×10^3 cell/L with an average of 41.80×10^3 cell/L,and Skeletonema sp.and Paralia sulcata was the most dominant species.In summer,the average phytoplankton cell abundance was 72.59×10^3 cell/L with the range of 1.78×10^3 to 574.96×10^3 cell/L,and the main dominant species was Pseudo-nitzschia pungens,Skeletonema sp.,Dactyliosolen fragilissima and Chaetoceros curvisetus.The results of a redundancy analysis(RDA)showed that turbidity,temperature,salinity,pH,dissolved oxygen(DO),the ratio of dissolved inorganic nitrogen to silicate and SiO4-Si(DIN/SiO4-Si)were the most important environmental factors controlling phytoplankton assemblages in spring or summer in the Subei Shoal of the Yellow Sea. | Yuanzi Huo Honghua Shi Jianheng Zhang Qiao Liu Yuanliang Duan Qing He Kefeng Yu Hongsheng Bi Chunlei Fan Peimin He | 2019 | Acta Oceanologica Sinica2019，38，10： | 4 |
| 5 | Spatiotemporal heterogeneity of phytoplankton diversity and its relation to water environmental factors in the southern waters of Miaodao Archipelago,China显示文摘To study the water quality influenced by the anthropogenic activities and its impact on the phytoplankton diversity in the surface waters of Miaodao Archipelago, the spatiotemporal variations in phytoplankton communities and the environmental properties of the surface waters surrounding the Five Southern Islands of Miaodao Archipelago were investigated, based on seasonal field survey conducted from November 2012 to August 2013. During the survey, a total of 109 phytoplankton species from 3 groups were identified in the southern waters of Miaodao Archipelago, of which 77 were diatoms, 29 were dinoflagellates, and 3 were chrysophytes. Species number was higher in winter(73), moderate in autumn(70), but lower in summer(31) and spring(27). The species richness index in autumn(5.92) and winter(4.28) was higher than that in summer(2.83) and spring(1.41).The Shannon-Wiener diversity index was high in autumn(2.82), followed by winter(1.99) and summer(1.92), and low in spring(0.07). The species evenness index in autumn(0.46) and summer(0.39) was higher than that in winter(0.32) and spring(0.02). On the basis of principal component analysis(PCA) and redundancy analysis(RDA), we found that dissolved inorganic nitrogen(DIN) and chemical oxygen demand(COD) in spring, COD in summer, p H in autumn, and salinity and oil pollutant in winter, respectively, showed the strongest association with the distribution of phytoplankton diversity. The spatial heterogeneity of the southern waters of Miaodao Archipelago was quite obvious, and three zones, i.e., northeastern, southwestern and inter-island water area, were identified by cluster analysis(CA) based on key environmental variables. | ZHENG Wei LI Fen SHI Honghua HUO Yuanzi LI Yan CHI Yuan GUO Zhen WANG Yuanyuan SHEN Chengcheng LIU Jian QIAO Mingyang | 2016 | Acta Oceanologica Sinica2016，35，2： | 3 |
| 6 | Structural basis of pre-mRNA recognition by the human cleavage factor Im complex显示文摘劈开因素我 m ( CF 我 m ),由 25 kDa 子单元组成( CF 我 m 25)并且三个更大的子单元之一( CF 我 m 59, CF 我 m 68, CF 我 m 72),并且一为 pre-mRNA 的必要蛋白质建筑群 3 ′ ;结束劈开和 polyadenylation 。它认出在上游的顺序 poly 以一种顺序依赖者方式的(A) 地点。这里,我们报导人的 CF 的水晶结构我 m , 包括 CF 我 m 25 和 CF 的 RNA 识别主题领域我 m 68 (CF 我 m 68RRM), 和 CF 的水晶结构我 m -RNA 建筑群。这些结构显示出那二 CF 我 m 68RRM 分子绑在 CF 我 经由形成 heterotetramer 的一个新奇 RRM 蛋白质相互作用模式更暗淡的 m 25。与反平行的取向,二 UGUAA RNA 定序的 RNA 固定的结构表演绑在一 CF 我 m 25-CF 我 m 68RRM heterotetramer,为由 CF 的机制提供结构的基础我 m 同时在 pre-mRNA 的一个分子以内绑二个 UGUAA 元素。点变化和运动分析表明那 CF 我 m 68RRM 能绑立即在上游的 flanking UGUAA 元素的区域,和 CF 我 m 68RRM 绑定显著地增加建筑群的RNA有约束力的亲密关系,建议那 CF 我 m 68 做必要贡献到 pre-mRNA 有约束力。 | Heng Li | 2011 | Cell Research2011，21，7： | 3 |
| 7 | Sensitivity and Uncertainty Analysis of Regional Marine Ecosystem Services Value显示文摘Marine ecosystem services are the benefits which people obtain from the marine ecosystem,including provisioning services,regulating services,cultural services and supporting services. The human species,while buffered against environmental changes by culture and technology,is fundamentally dependent on the flow of ecosystem services. Marine ecosystem services become increasingly valuable as the terrestrial resources become scarce. The value of marine ecosystem services is the monetary flow of ecosystem services on specific temporal and spatial scales,which often changes due to the variation of the goods prices,yields and the status of marine exploitation. Sensitivity analysis is to study the relationship between the value of marine ecosystem services and the main factors which affect it. Uncertainty analysis based on varying prices,yields and status of marine exploitation was carried out. Through uncertainty analysis,a more credible value range instead of a fixed value of marine ecosystem services was obtained in this study. Moreover,sensitivity analysis of the marine ecosystem services value revealed the relative importance of different factors. | SHI Honghua ZHENG Wei WANG Zongling DING Dewen | 2009 | Journal of Ocean University of China2009，8，2： | 3 |
| 8 | Benefit and cost analysis of maricuhure based on ecosystem services 显示文摘 | Zheng Wei Shi Honghua | 2009 | Ecological Econom- /cs2009，68，6： | 1 |
| 9 | Benefit and cost analysis of mariculture based on ecosystem services显示文摘 | Zheng Wei Shi Honghua Chen Shang | | 0，，06： | 1 |
| 10 | Application of macrobenthos functional groups to estimate the ecosystem health in a semi-enclosed bay显示文摘 | Shitao Peng Ran Zhou Xuebo Qin Honghua Shi Dewen Ding | 2013 | Marine Pollution Bulletin2013，，： | 1 |
| 11 | Benefit and cost analysis of mariculture based on ecosystem services显示文摘 | Zheng Wei Shi Honghua Chen Shang | 2009 | Ecological Economics2009，68，6： | 1 |
| 12 | Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression显示文摘Atrial fibrillation(AF)is a frequent arrhythmia associated with cardiovascular morbidity and mortality.Neutrophil extracellular traps(NETs)are DNA fragments with cytoplasm proteins released from neutrophils,which are involved in various cardiovascular diseases.To elucidate the role of NETs in AF,we investigated the effect of NETs on AF progression and the secretion of NETs in AF.Results showed that:NETs induced the autophagic apoptosis of cardiomyocytes,and NETs also led to mitochondrial injury by promoting mitochondrial depolarization and ROS production.Ongoing tachy-pacing led to the structural loss of cardiomyocytes and provided potent stimuli to induce NETs secretion from neutrophils.In the meanwhile,increased Ang II in AF facilitated NETs formation through the upregulation of AKT phosphorylation,while it could not directly initiate NETosis as the autophagy was not induced.In vivo,DNase I was administrated to abrogate NETs formation,and AF-related fibrosis was ameliorated as expected.Correspondingly,the duration of the induced AF was reduced.Our study addresses the formation mechanism of NETs in AF and demonstrates the lethal effects of NETs on cardiomyocytes through the induction of mitochondrial injury and autophagic cell death,which comprehensively describes the positive feedback comprised of NETs and stimuli secreted by cardiomyocytes that sustains the progression of AF and AF related fibrosis. | Li He Ruiqi Liu Honghua Yue Xiaoxin Zhang Xiaohui Pan Yutao Sun Jun Shi Guonian Zhu Chaoyi Qin Yingqiang Guo | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 1 |
| 13 | Analysis of Tire Industry Operation in 2014显示文摘Last year,China rubber industry had a'perturbed year',it entered 2014 in optimism and steps into 2015 in pessimism.According to the statistics of China Rubber Industry Association on 46 main tire enterprises,obvious deviation showed in the main indicators of tire industry,that is,the output | Shi Honghua Chen Weifang | 2015 | 中国橡胶2015，31，8： | 0 |
| 14 | The Inhibitory Effects of PSS-Loaded Nanoparticles on the Dysfunction of Cardiac Microvascular Endothelia in Rats with Diabetic Cardiomyopathy显示文摘Propylene glycol alginate sodium sulfate-loaded nanoparticles(PSS-NP) has been shown potential to prevent the microvascular endothelial injuries caused by diabetic cardiomyopathy(DCM). In this study, we aimed to investigate the effects of PSS-NP on the dysfunction of cardiac microvascular endothelia in streptozotocin(STZ)-induced DCM rat model. Echocardiographic measurements showed a significant improvement of cardiac function in the PSS-NP-treated group. Our results revealed that the abnormalities of cardiac systolic and diastolic functions were suppressed by the treatments of prostaglandin E1(PGE1), low molecular weight heparin(LMWH), PSS and PSS-NP. Our comparison analysis indicated that PSS-NP showed the strongest inhibitory effects on microvascular endothelial injuries. Transmission electron microscopy analysis demonstrated that PSS-NP protected the cardiac microvascular endothelium and further improved endothelium dysfunction in DCM rats. ELISA and Western blot assays further showed a high efficiency of improving cardiac microvascular endothelial dysfunction with PSS-NP. Our results demonstrated that PSS-NP increased the protein expression of phosphatidylinositol 3-kinase(PI3K)-p85 and vascular endothelial growth factor(VEGF)-A, and the phosphorylation of protein kinase B(Akt) and endothelial nitric oxide synthase(eNOS), which were involved in the amelioration of cardiac microvascular endothelial dysfunction. These data suggest that PSS-NP may be a novel approach to the treatment the coronary microcirculation disorder diseases such as DCM. | AN Nina YU Luyan HU Yi FENG Wenjing SHI Shujuan CHEN Honghua MAO Yongjun | 2019 | Journal of Ocean University of China2019，18，1： | 0 |
| 15 | Landscape changes and their ecological eff ects of Miaodao Archipelago with human disturbances and under natural conditions in the past 30 years显示文摘The modern landscape patterns of islands usually show obvious spatial heterogeneity and complex ecological effects due to the vulnerability of ecosystems with natural characteristics under increasing human activities.In this work,we studied the variation in landscape pattern of the Miaodao Archipelago in Bohai Sea,North China,from 1990 to 2019,and an evaluation index system was established to explore the impacts of natural conditions and human disturbances on the ecological effects in the pressure-state-response(PSR)framework.Empirical analysis was conducted on the natural conditions,human disturbances,and ecological effects.The results show that forest was the main component of the landscape pattern in the archipelago.Both of the areas offorest and construction land were increasing,and the areas of cropland and grassland were declining.Other landscape types changed slightly,and the landscape fragmentation was increasing.The natural condition exhibited positive effects while human disturbance showed negative effects on the local ecology.Human disturbances come mainly from shoreline use while the natural conditions were mainly from the elevation change.The ecological effects were resulted mainly from the net primary productivity and water yield. | Honghua SHI Liting YIN Meng GAO | 2021 | Journal of Oceanology and Limnology2021，39，3： | 0 |
| 16 | Multi-objective optimal design for AC filters in high voltage direct current system based on improved multi-objective evolutionary algorithm based on decomposition显示文摘A triple-objective optimal design method for AC filters in high voltage direct current(HVDC)system based on an improved multi-objective evolutionary algorithm based on decomposition(MOEA/D)is proposed.A triple-objective optimisation mathematical model including total harmonic distortion(THD)on AC side voltage,investment cost of AC filters and telephone harmonic form factor(THFF)is established.An improved MOEA/D is proposed to realise the triple-objective optimal design for AC filters more efficiently.The improved MOEA/D adds a particular mutation operator,which can not only to prevent MOEA/D from getting stuck at local optimum but also accelerate the convergence to the optimum solution while the algorithm approaches the neighbourhood of the optimum solution.A three-dimensional fuzzy evaluation system is designed to select the optimum solution of the triple-objective optimisation.A case of±500 kV HVDC system is simulated.Taking the±500 kV HVDC system as the prototype system,a dynamic simulation experimental platform of the rectification system of the direct current transmission system with AC filters is designed and established based on the similarity principle.Both the simulation and experimental results verify that the proposed method have excellent performance. | Fan Shi Honghua Wang Tianhang Lu Jiawei Huang Chengliang Wang | 2023 | High Voltage2023，8，3： | 0 |
| 17 | Degeneration of foundation cushion species induced by ecological constraints can cause massive changes in alpine plant communities显示文摘Foundational cushion plants can re-organize community structures and sustain a prominent proportion of alpine biodiversity,but they are sensitive to climate change.The loss of cushion species can have broad consequences for associated biota.The potential plant community changes with the population dynamics of cushion plants remain,however,unclear.Using eight plant communities along a climatic and community successional gradient,we assessed cushion population dynamics,the underlying ecological constraints and hence associated plant community changes in alpine communities dominated by the foundational cushion plant Arenaria polytrichoides.The population dynamics of Arenaria are attributed to ecological constraints at a series of life history stages.Reproductive functions are constrained by increasing associated beneficiary plants;subsequent seedling establishment is constrained by temperature,water and light availability,extreme climate events,and interspecific competition;strong competitive exclusion may accelerate mortality and degeneration of cushion populations.Along with cushion dynamics,species composition,abundance and community structure gradually change.Once cushion plants completely degenerate,previously cushion-dominated communities shift to relatively stable communities that are overwhelmingly dominated by sedges.Climate warming may accelerate the degeneration process of A.polytrichoides.Degeneration of this foundational cushion plant will possibly induce massive changes in alpine plant communities and hence ecosystem functions in alpine ecosystems.The assessment of the population dynamics of foundation species is critical for an effective conservation of alpine biodiversity. | Jianguo Chen Xufang Chen Lishen Qian Yazhou Zhang Bo Li Honghua Shi Lu Sun Christian Schöb Hang Sun | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 18 | Research on stability and Hopf bifurcation of marine ecosystem dynamics models显示文摘The predictability of marine ecosystem dynamics models is one of the most vital factors to limit their practical applications, of which the stability is the fundamental condition. In order to discuss the stability and Hopf bifurcation of marine ecosystem dynamics models, an approach based on a theorem termed dimension reduction was proposed and further applied in the mass-conservative nutrient-phytoplankton-zooplankton-detritus(NPZD) model in this paper. Results showed that the nonsingular equilibrium point of NPZD model was analytically stable in use of the dimension reduction theorem and the Hopf bifurcation might occur when model parameters changed along the threshold values. The analytical results of the NPZD model were further verified by numerical simulation in this study. It can be concluded that this approach based on the dimension reduction theorem is well applicable to the theoretical analysis of a kind of stability problems and Hopf bifurcation of massconservative systems. | SHI Honghua HU Long FANG Guohong WEI Zexun SHEN Chengcheng LIU Yongzhi | 2016 | Acta Oceanologica Sinica2016，35，4： | 0 |
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