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| 1 | Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor显示文摘In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor(GIST) in China, the members of Chinese Society of Clinical Oncology(CSCO) Expert Committee on GIST thoroughly discussed the key contents of the consensus guidelines, and voted on the controversial issue. In final, the Chinese consensus guidelines for the diagnosis and management of GIST(2017 edition) was formed on the basis of 2013 edition consensus guidelines, which is hereby announced. The consensus included the pathological diagnosis,recurrence risk classification evaluation, targeted agent therapy, surgery and principles of surveillance of GIST. | jian li yingjiang ye jian wang bo zhang shukui qin yingqiang shi yulong he xiaobo liang xiufeng liu ye zhou xin wu xinhua zhang ming wang zhidong gao tianlong lin hui cao lin shen | 2017 | Chinese Journal of Cancer Research2017，29，4： | 104 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 4 | Exploring Genome-wide DNA Methylation Profiles Altered in Kashin-Beck Disease Using Infinium Human Methylation 450 Bead Chips显示文摘To understand how differentially methylated genes(DMGs)might affect the pathogenesis of Kashin-Beck disease(KBD).Genome-wide methylation profiling of whole blood from 12matched KBD and controls pairs was performed using a high-resolution Infinium 450 K methylation array.In total,97 CpG sites were | SHI Xiao Wei SHI Bo Hui LYU Ai Li ZHANG Feng ZHOU Tian Tian GUO Xiong | 2016 | Biomedical and Environmental Sciences2016，29，7： | 4 |
| 5 | LNCaP衍生的雄激素非依赖型前列腺癌细胞系C4-2对辐射的应答反应显示文摘放射治疗是治疗局灶性前列腺癌相对有效的方法,然而,30%的病人会产生辐射治疗抵抗。放射协同雄激素撤除为临床提供了一种改善疗效的治疗方法。雄激素撤除诱导的信号通路相应地也会介导前列腺癌细胞的放射敏感。C4—2细胞是由雄激素非依赖的LNCaP母体细胞在雄激素撤除条件下衍生而来的,C4-2细胞获得了雄激素非依赖生长的特性。我们分析了LNCaP和WC4-2对辐射的应答反应,克隆形成、细胞存活和细胞周期分析结果显示,C4-2细胞经照射后较LNCaP细胞更容易存活,对辐射处理表现出更强的抵抗能力。基因表达分析表明,一整套与细胞周期阻滞和DNA损伤相关的基因经过辐射处理后在LNCaP和C4.2细胞中差异表达,其结果与C4—2细胞的辐射抵抗性质一致,这些结果明显提示,前列腺癌细胞对辐射的抵抗与向雄激素非依赖发展的过程可能同步进行。LNCaP和C4-2细胞模型不仅可应用于研究前列腺癌向雄激素非依赖发展的过程,而且也用于分析前列腺癌细胞的辐射抵抗机制。 | Bang-Xiang Xie Hui Zhang Lan Yu Jian Wang Bo Pang Rui-Qin Wu Xiao-Long Qian Shan-Hu Li Qing-Guo Shi Le-Le Wang Jian-Guang Zhou | 2010 | Asian Journal of Andrology2010，12，3： | 4 |
| 6 | Concise and efficient direct-view generation of arbitrary cylindrical vector beams by a vortex half-wave plate显示文摘A concise, efficient, and practical direct-view scheme is presented to generate arbitrary cylindrical vector(CV)beams, including CV beams, vortex beams, and cylindrical vector vortex(CVV) beams, by a vortex half-wave plate(VHP). Six kinds of first-order and other high-order CV beams, such as azimuthally polarized(AP) beams, antivortex radial polarization mode beams, and three-order AP beams, are formed by simply rotating a half-wave plate. The Stokes parameters and double-slit interference of multitype CV beams are investigated in detail.The polarization parameters, including degree of polarization, polarization azimuth, and ellipticity, are obtained,which demonstrates the efficient generation of CV beams. In addition, the double-slit interference experiment is introduced in the setup, and fringe misplacement and tilt appear for CVV beams, in which the misplacement number M is 2P+1 for P ≤ 2 and 2P-1 for P ≥ 3, where P is the polarization order number, and the fringe tilt offset is positively related to the topological charge number l of CVV beams. In addition, new types of VHPs can be formed by cascading two or more VHPs when the types of available VHPs are limited, assisting in more flexible generation of multitype CV beams. It is experimentally demonstrated that arbitrary CV beams with high quality are effectively achieved by the proposed setup, and the double-slit interference method can be utilized to determine and analyze CV beams rapidly and concisely by practical performance, which shows the potential to be implemented as a commercial device. | JUNLI QI WEIHUA WANG BO SHI HUI ZHANG YANAN SHEN HAIFEI DENG WENJING PU XIN LIU HUIHUI SHAN XIAOMIN MA LIANQIANG ZHANG WEI LU MEICHENG FU XIUJIAN LI | 2021 | Photonics Research2021，9，5： | 4 |
| 7 | Human epidermal growth factor receptor 2 expression in mixed gastric carcinoma显示文摘AIM: To investigate human epidermal growth factor receptor 2(HER2) amplification and protein expression in mixed gastric carcinoma.METHODS: Fluorescence in situ hybridization and immunohistochemistry were used to detect HER2 amplification and protein expression in 277 cases of mixed gastric carcinoma. Protein staining intensity was rate as 1+, 2+, or 3+.RESULTS: Of the 277 cases, 114(41.2%) expressed HER2 protein. HER2 3+ staining was observed in 28/277(10.1%) cases, 2+ in 37/277(13.4%) cases, and 1+ in 49/277(17.7%) cases. A HER2 amplification rate of 17% was detected, of which 25/28(89.3%) were observed in the HER2 3+ staining group, 17/37(45.9%) in 2+, and 5/49(10.2%) in 1+. Of the 47 patients with HER2 amplification who received chemotherapy plus trastuzumab, 22 demonstrated median progression-free and overall survivals of 9.1 mo and 16.7 mo, respectively, which were significantly better than those achieved with chemotherapy alone(5.6 mo and 12.1 mo, respectively) in 19 previously treated patients(P s < 0.05). CONCLUSION: HER2 detection in mixed gastric carcinoma displays high heterogeneity. Relativelyquantitative parameters are needed for assessing the level of HER2 amplification and protein expression. | Yang-Kun Wang Zhong Chen Tian Yun Cong-Yang Li Bo Jiang Xue-Xia Lv Guang-Hui Chu Su-Nan Wang Hui Yan Lei-Feng Shi | 2015 | World Journal of Gastroenterology2015，21，15： | 4 |
| 8 | DCZ0801,a novel compound,induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma显示文摘Multiple myeloma(MM)is a refractory malignant hematological malignancy,and many therapeutic strategies have been developed to cure patients with MM.DCZ0801 is a compound that consists of oxophenamide and pterostilbene.The role of these compounds in hematological cancers such as MM has yet to be studied.In this study,we explored the potential mechanism of DCZ0801 action,its anti-tumor activity both in vitro and in vivo on MM.This study was carried out via cell cycle proliferation assay,apoptotic analysis,western blot analysis,and examination of xenotransplantation model of tumors.The in vitro studies revealed that DCZ0801 could inhibit cell proliferation and induce apoptosis by regulating both caspase-dependent and mitogen-activated protein kinase signaling pathways,inducing S-phase arrest of the cell cycle related to downregulation of CDK2,cyclin-A2,and CDC25A protein expression.The in vivo studies showed that DCZ0801 could significantly reduce the size of the tumors in nude mice.Our results demonstrated that DCZ0801 may emerge as the new therapeutic option for the patient with MM. | Ting Zhang Bo Li Qilin Feng Zhijian Xu Cheng Huang Huiqun Wu Zhangbo Chen Liangning Hu Lu Gao Peng Liu Guang Yang Hui Zhang Kang Lu Tingye Li Yi Tao Xiaosong Wu Jumei Shi Weiliang Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 3 |
| 9 | Semen parameters in men recovered from COVID-19显示文摘The novel coronavirus disease(COVID-19)pandemic is emerging as a global health threat and shows a higher risk for men than women.Thus far,the studies on andrological consequences of COVID-19 are limited.To ascertain the consequences of COVID-19 on sperm parameters after recovery,we recruited 41 reproductive-aged male patients who had recovered from COVID-19,and analyzed their semen parameters and serum sex hormones at a median time of 56 days after hospital discharge.For longitudinal analysis,a second sampling was obtained from 22 of the 41 patients after a median time interval of 29 days from first sampling.Compared with controls who had not suffered from COVID-19,the total sperm count,sperm concentration,and percentages of motile and progressively motile spermatozoa in the patients were significantly lower at first sampling,while sperm vitality and morphology were not affected.The total sperm count,sperm concentration,and number of motile spermatozoa per ejaculate were significantly increased and the percentage of morphologically abnormal sperm was reduced at the second sampling compared with those at first in the 22 patients examined.Though there were higher prolactin and lower progesterone levels in patients at first sampling than those in controls,no significant alterations were detected for any sex hormones examined over time following COVID-19 recovery in the 22 patients.Although it should be interpreted carefully,these findings indicate an adverse but potentially reversible consequence of COVID-19 on sperm quality. | Tong-Hang Guo Mei-Ying Sang Shun Bai Hui Ma Yang-Yang Wan Xiao-Hua Jiang Yuan-Wei Zhang Bo Xu Hong Chen Xue-Ying Zheng Si-Hui Luo Xue-Feng Xie Chen-Jia Gong Jian-Ping Weng Qing-Hua Shi | 2021 | Asian Journal of Andrology2021，23，5： | 2 |
| 10 | Distinctive Drug-resistant Mutation Profiles and Interpretations of HIV-1 Proviral DNA Revealed by Deep Sequencing in Reverse Transcriptase显示文摘Objective To investigate distinctive features in drug-resistant mutations(DRMs) and interpretations for reverse transcriptase inhibitors(RTIs) between proviral DNA and paired viral RNA in HIV-1-infected patients. Methods Forty-three HIV-1-infected individuals receiving first-line antiretroviral therapy were recruited to participate in a multicenter AIDS Cohort Study in Anhui and Henan Provinces in China in 2004. Drug resistance genotyping was performed by bulk sequencing and deep sequencing on the plasma and whole blood of 77 samples, respectively. Drug-resistance interpretation was compared between viral RNA and paired proviral DNA. Results Compared with bulk sequencing, deep sequencing could detect more DRMs and samples with DRMs in both viral RNA and proviral DNA. The mutations M184 I and M230 I were more prevalent in proviral DNA than in viral RNA(Fisher's exact test, P<0.05). Considering ‘majority resistant variants', 15 samples(19.48%) showed differences in drug resistance interpretation between viral RNA and proviral DNA, and 5 of these samples with different DRMs between proviral DNA and paired viral RNA showed a higher level of drug resistance to the first-line drugs. Considering ‘minority resistant variants', 22 samples(28.57%) were associated with a higher level of drug resistance to the tested RTIs for proviral DNA when compared with paired viral RNA. Conclusion Compared with viral RNA, the distinctive information of DRMs and drug resistance interpretations for proviral DNA could be obtained by deep sequencing, which could provide more detailed and precise information for drug resistance monitoring and the rational design of optimal antiretroviral therapy regimens. | YIN Qian Qian LI Zhen Peng ZHAO Hai PAN Dong WANG Yan XU Wei Si XING Hui FENG Yi JIANG Shi Bo SHAO Yi Ming MA Li Ying | 2016 | Biomedical and Environmental Sciences2016，29，4： | 2 |
| 11 | Nerve Growth Factor for the Treatment of Spinocerebellar Ataxia Type 3: An Open-label Study显示文摘 | Song Tan Rui-Hao Wang Hui-Xia Niu Chang-He Shi Cheng-Yuan Mao Rui Zhang Bo Song Shi-Lei Sun Xin-Jing Liu Hai-Man Hou Yu-Tao Liu Yuan Gag Hui Fang Xiang-Dong Kong Yu-Ming Xu | 2015 | Chinese Medical Journal2015，，3： | 2 |
| 12 | Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats显示文摘Characterizing the three-dimensional (3D) morphological alterations of microvessels under both normal and seizure conditions is crucial for a better understanding of epilepsy. However, conventional imaging techniques cannot detect microvessels on micron/sub-micron scales without angiography. In this study, synchrotron radiation(SR)-based X-ray in-line phase-contrast imaging (ILPCI)and quantitative 3D characterization were used to acquire high-resolution, high-contrast images of rat brain tissue under both normal and seizure conditions. The number of blood microvessels was markedly increased on days 1 and 14, but decreased on day 60 after seizures. The surface area, diameter distribution, mean tortuosity, and number of bifurcations and network segments also showed similar trends. These pathological changes were confirmed by histological tests. Thus, SR-based ILPCI provides systematic and detailed views of cerebrovascular anatomy at the micron level without using contrast-enhancing agents. This holds considerable promise for better diagnosis and understanding of the pathogenesis and development of epilepsy. | Pan Gu Zi-Hao Xu Yu-Ze Cao Sheng-Hui Liao Qian-Fang Deng Xian-Zhen Yin Zhuo-Lu Wang Zhuo-Hui Chen Xin-Hang Hu Hui Wang Li-Zhi Li Shi-Xin Liu Hul Ding Shu-Peng Shi Hong-Lei Li Ti-Qiao Xiao Bo Xiao Meng-Qi Zhang | 2020 | Neuroscience Bulletin2020，36，4： | 2 |
| 13 | Effect of endothelial progenitor cells derived from human umbilical cord blood on oxygen-induced retinopathy in mice by intravitreal transplantation显示文摘·AIM: To investigate the effect of endothelial progenitor cells(EPCs) labeled by carboxy fluorescein diacetate succinimidyl ester(CFSE) on murine oxygen-induced retinopathy(OIR) by intravitreal transplantation.·METHODS: After isolated from human umbilical cord blood mononuclear cells, EPCs were cultivated and then labeled with CFSE in vitro. C57BL/6J mice were placed to75% hyperoxia chamber from P7 to P12 to establish OIR model. At P12, OIR mice were intravitreally injected with1 μL suspension contained 2×105EPCs(EPCs group) or isometric phosphate buffered saline(PBS group). The contralateral eye of each mice received no injection(OIR group). Evans blue angiography and frozen section were examined to track the labeled cells in OIR group at P15 and P19. Using retina paraffin sections and adenosinediphos phatase staining at P12 and P19, the effect of EPCs on OIR mice was evaluated quantitatively and qualitatively.· RESULTS: The retinas from EPCs group with less non-perfusion area and fewer peripheral tufts wereobserved at P19, comparing with that from PBS or OIR group. The retinopathy in EPCs group receded earlier with less non-ganglion cells and neovascular nuclei,together with relatively regular distribution. The counts of the neovascular nuclei at P19 were reduced by 44% or45%, compared with those of OIR group or PBS group respectively. Three days after EPCs injection, a large number of EPCs appeared in the vitreous cavity and adhered to the retinal surface. While at one week, the cells gathered between the internal plexiform layer and the inner limiting membrane, and some EPCs appeared in retinal vessels.·CONCLUSION: EPCs transplantation can participate in the reparative procedure of the neovascularization in OIR. | Dan Wang Bo Zhang Hui Shi Wei Yang Ming-Chao Bi Xiang-Fu Song Chen Zhang Jian-Hui Cheng Ji-Long Hao E Song | 2016 | International Journal of Ophthalmology(English edition)2016，9，11： | 2 |
| 14 | High-resolution characterization of hexagonal boron nitride coatings exposed to aqueous and air oxidative environments显示文摘六角形的硼氮化物(h-BN ) 被相信由于它的绝缘的性质比 graphene 把更好的钝化提供给金属性的表面,它便于堵住电子的流动,从而阻止流电的反应的出现。不过,当 h-BN-protected 材料暴露于水的环境时,这不能是盒子。在这个工作,我们分析了暴露于 H 2 O 2 和大气的条件。当暴露了到 H 2 O 2 。多层的 h-BN 提供了保护的好度。单层 h-BN 被发现也在空气气氛无效。甚至 10-15 层厚的 h-BN 栈不能完全在考虑下面保护金属的表面。由联合钻电子光谱学和第二等的离子团 spectrometry 技术,我们观察到氧能通过 h-BN 栈的谷物边界扩散到达金属性的底层。因为这个过程的散开的性质,一旦一个浸透的状态被到达,幸好,氧化区域没与时间增加。这成为多层(不单层) h-BN 一个合适的长期的氧化障碍。氧渗入不能被 X 光检查光电子光谱学观察。这种技术不能估计材料的更深的层的化学作文。因此,以前的报告,依靠了 XPS 分析 h-BN 和 graphene 的使钝化的性质,可能忽略了一些重要表面下的现象。在这研究获得的结果在水的媒介和暴露于空气环境的 h-BN-coated 金属的降级动力学提供新卓见进单音、多层的 h-BN 的使钝化的性质。 | Lanlan Jiang Na Xiao Bingru Wang Enric Grustan-Gutierrez Xu Jing Petr Babor Miroslav Kogbal Guangyuan Lu Tianru Wu Haomin Wang Fei Hui Yuanyuan Shi Bo Song Xiaoming Xie Mario Lanza | 2017 | Nano Research2017，10，6： | 2 |
| 15 | Efficacy and Safety of SGLT2 Inhibitors in Patients with Type 1 Diabetes:A Meta-analysis of Randomized Controlled Trials显示文摘Objective To assess the efficiency and safety of a novel sodium-glucose co-transporter 2(SGLT2) inhibitor—SGLT2 inhibitors,in combination with insulin for type 1 diabetes mellitus(T1DM). Methods We searched Medline,Embase,and the Cochrane Collaboration Library to identify the eligible studies published between January 2010 and July 2016 without restriction of language. The Food and Drug Administration(FDA) data and Clinical Trials(http://gffzz1caf53c915c04334h6ncv5fq5x9pk6kkn.ffgz.tsg.suse.edu.cn) were also searched. The included studies met the following criteria:randomized controlled trials; T1DM patients aged between 18 and 65 years old; patients were treated with insulin plus SGLT2 inhibitors for more than 2 weeks; patients' glycosylated hemoglobin(HbA1c) levels were between 7% and 12%. The SGLT2 inhibitors group was treated with SGLT2 inhibitors plus insulin,and the placebo group received placebo plus insulin treatment. The outcomes should include one of the following items:fasting blood glucose,HbA1c,glycosuria,or adverse effects. Data were analyzed by two physicians independently. The risk of bias was evaluated by using the Cochrane Collaboration's Risk of Bias tool and heterogeneity among studies was assessed using Chi-square test. Random effect model was used to analyze the treatment effects with Revman 5.3. Results Three trials including 178 patients were enrolled. As compared to the placebo group,SGLT2 inhibitor absolutely decreased fasting blood glucose [mean differences(MD)-2.47 mmol/L,95% confidence interval(CI)-3.65 to-1.28,P<0.001] and insulin dosage(standardized MD-0.75 U,95%CI-1.17 to-0.33,P<0.001). SGLT2 inhibitors could also increase the excretion of urine glucose(MD 131.09 g/24 h,95%CI 91.79 to 170.39,P<0.001). There were no significant differences in the incidences of hyperglycemia [odds ratio(OR) 1.82,95%CI 0.63 to 5.29,P=0.27],urinary tract infection(OR 0.95,95%CI 0.19 to 4.85,P=0.95),genital tract infection(OR 0.27,95%CI 0.01 to 7.19,P=0.43),and diabetic ketoacidosis(OR 6.03,95%CI 0.27 to 135.99,P=0.26) between the two groups. Conclusion SGLT2 inhibitors combined with insulin might be an efficient and safe treatment modality for T1DM patients. | Yingying Yang Hui Pan Bo Wang Shi Chen Huijuan Zhu | 2017 | Chinese Medical Sciences Journal2017，32，1： | 2 |
| 16 | CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration显示文摘RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro.In this perspective,we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macular degeneration. | Changyang Zhou Xinde Hu Cheng Tang Wenjia Liu Shaoran Wang Yingsi Zhou Qimeng Zhao Qiyu Bo Linyu Shi Xiaodong Sun Haibo Zhou Hui Yang | 2020 | National Science Review2020，7，5： | 2 |
| 17 | CO2 capture by dectrothermal swing adsorption with activated carbon fibre materials显示文摘 | Hui An Bo Feng Shi Su | | 0，，： | 1 |
| 18 | UV- spectrophotometric screening of 5α- reductase inhibitors for benign prostatic hyperplasia treatment显示文摘 | XU Dong - hui WANG Zhao - he WANG Li - hong MEI Xue - ting XU Shi - bo | 2007 | 中国病理生理杂志2007，23，4： | 1 |
| 19 | Epidemic of Rabies and Effect of Its Vaccine against a Dog That Consecutively Attacked Ten People in One Day显示文摘On December 21,2010,a stray dog consecutively attacked 10 people in Lengshui Village,Ningyuan County,Yongzhou City,Hunan Province,China.The dog was killed by the local CDC staff and vicinity villager,its brain tissue sample was taken within 24 h.The epidemic focus was disinfected and the injured people received post exposure prophylaxis(PEP).Pathogens were detected in the tissue sample by the provincial CDC.The immunity and safety of rabies vaccine were assayed after PEP,the injured people were regularly followed up in the following 2 y and 6 mon. | GAO Li Dong ZHANG Hong CAI Liang CHEN Bo Zhong JIANG Yong Lin LIU Yun Zhi LV Xin Jun YU Peng Cheng HU Shi Xiong LIU Fu Qiang LI Hao LI Ge Ying SHEN Xin Xin TAO Xiao Yan ZHANG Si Yu LIU Jia Hui TANG Qing LI Jun Hua | 2014 | Biomedical and Environmental Sciences2014，27，1： | 1 |
| 20 | Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma显示文摘 | Bo Hui Ying‐Hong Shi Zhen‐Bin Ding Jian Zhou Cheng‐Yu Gu Yuan‐Fei Peng Hua Yang Wei‐Ren Liu Guo‐Ming Shi Jia Fan | 2012 | Cancer2012，，22： | 1 |
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