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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | Dynamic Fracture Toughness of Armour Grade Quenched and Tempered Steel Joints Fabricated Using Low Hydrogen Ferritic Fillers显示文摘The armour grade quenched and tempered steel joints fabricated using low hydrogen ferritic steel (LHF) filler exhibited superior joint efficiency owing to preferential ferrite microstructure in the welds and also they offered required resistance to HIC. However, the combat vehicles used in military operations will be required to operate under a wide range of road conditions ranging from first class to cross country. Structural components in combat vehicles are subjected to dynamic loading with high strain rates during operation. Stress loadings within the vehicle hull of these vehicles are expected to fluctuate considerably and structural cracking especially in welds during the service life of these vehicles can lead to catastrophic failures. Under these conditions, fracture behaviour of high strain rate sensitive structural steels can be better understood by dynamic fracture toughness (K1d). Hence, an attempt was made to study dynamic fracture toughness of the armour grade quenched and tempered steel and their welds fabricated using LHF consumables. The experimental results indicate that the K1d values of the joints fabricated by shielded metal arc welding (SMAW) are higher than those of the joints fabricated using flux cored arc welding (FCAW) process. | G Magudeeswaran V Balasubramanian S Sathyanarayanan G Madhusudhan Reddy A Moitra S Venugopal G Sasikala | 2010 | Journal of Iron and Steel Research(International)2010，17，5： | 2 |
| 3 | Electrodeposition and optical characterization of CdS thin films on ITO-coated glass显示文摘 | Dhnasekaran R Subramanian C | 1997 | Thin Solid Films1997，302，： | 1 |
| 4 | Modification in the chemical bath deposition apparatus,growth and characterization of CdS semiconducting thin films for Photovoltaic applications显示文摘 | SASIKALA G THILAKAN P SUBRAMANNIAN C | 2000 | Solar Energy Materials & Solar Cells2000，62，3： | 1 |
| 5 | Influence of carbon and nitrogen on the creep properties of type 316 stainless steel at 873 K 显示文摘 | Mathew M D Sasikala G Bhanu Sankara Rao K | 1991 | Materials Science and Engineering A1991，148，2： | 1 |
| 6 | Evaluation of dynamic fracture toughness of cold worked 9Cr-lMo steel 显示文摘 | Sathyanarayanan S Sasikala G Ray S K | 2004 | International Journal of Pressure Vessels and Piping2004，81，5： | 1 |
| 7 | Electrodeposition and optical characterization of CdS thin film on ITO- coated glass 显示文摘 | Sasikala G hnasekaran R D Subramanian C | 1997 | Thin Solid Films1997，302，： | 1 |
| 8 | Fatigue crack growth mechanism in aged 9Cr-1Mo steel: threshold and Paris regimes显示文摘 | Vibhor Chaswal Sasikala G Ray S K | 2005 | Materials Science and Engineering2005，395，12： | 1 |
| 9 | Modification in the Chemical Bath Deposition Apparatus, Growth and Characterization of CdS Semiconducting Thin Films for Photovoltaic Applications显示文摘 | Sasikala G Thilakan P Subramanian C | 2000 | Solar Energy Materials and Solar Cells2000，62，： | 1 |
| 10 | Modification in the chemical bath deposition apparatus, growth and char- acterization of CdS semiconducting thin films for photo- voltaic applications显示文摘 | Sasikala G Thilakan P Subramanian C | 2000 | Solar Energy Materials & Solar Cells2000，62，： | 1 |
| 11 | Investigation on influence of dynamic strain ageing on fatigue crack growth behaviour of modified 9Cr-lMo steel显示文摘 | Nani B M Sasikala G Shashank D B | 2012 | Interna- tional Journal of Fatigue2012，43，： | 1 |
| 12 | Modification in the chemical bath deposition apparatus,growth and characterization for photovoltaic applications显示文摘 | Sasikala G Thilakan P Subramanian C | 2000 | Solar Energy Materials & Solar Cells2000，62，： | 1 |
| 13 | Evaluation of Quasistatic Fracture Toughness of a Modified 9Cr-1Mo (P91) Steel显示文摘 | Sasikala G Ray S K | 2008 | Materials Science and Engineering A2008，479，12： | 1 |
| 14 | Evaluation of dynamic fracture toughness of cold worked 9Cr-1Mo steel显示文摘 | Sathyanarayanan S Sasikala G Ray S K | 2004 | International Journal of Pressure Vessels and Piping2004，81，： | 1 |
| 15 | Comparison of syndromic diagnosis of reproductive tract infections with laboratory diagnosis among rural married women in Medak district,Andhra Pradesh 显示文摘 | Prabha ML Sasikala G Bala S | 2012 | Indian J Sex Transm Dis2012，33，2： | 1 |
| 16 | Eleetrodeposition and optical characterisation of CdS thin films on ITO-eoated glass显示文摘 | Sasikala G Dhanasekaran R Subramanian C | 1997 | Thin Solid Films1997，302，1： | 1 |
| 17 | Electrodeposition and opticalcharacterisation of CdS thin films on ITO-coated glass显示文摘 | Sasikala G Dhanasekaran R Subramanian C | 1997 | Thin Solid Films1997，302，： | 1 |
| 18 | Modification in the chemical bath deposition apparatus, growth and characterization of CdS semiconducting thin films for photovoltaic applications显示文摘 | G Sasikala P Thilakan C Subramanian | 2000 | Solar Energy Materials and Solar Cells2000，，： | 1 |
| 19 | Evaluation of dynamic fracture toughness of cold worked 9Cr-lMo steel显示文摘 | Sathyanarayanan S Sasikala G Ray S K | 2004 | International Journal of Pressure Vessels and Piping2004，，81： | 1 |
| 20 | Fatigue crack growth mechanism in aged 9Cr-lMo steel: Threshold and paris re- gimes 显示文摘 | Chaswal V Sasikala G Ray S K | 2005 | Materials Science and Engineering2005，395，12： | 1 |
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