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| 1 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 2 | Evalutation of cytokine gene expression in porcine spleen cells, peripheral blood mononuclear cells, and alveolar macrophages by competitive RT-PCR显示文摘 | In-Soo C Ellen W C Samuel K M | 2002 | FEMS Immunol Med Microbiol2002，34，： | 1 |
| 3 | Stabilization and path following of a single wheel robot显示文摘 | YANGSHENG XU SAMUEL K W | 2004 | IEEE/ASME Transactions on Mechatronics2004，9，2： | 1 |
| 4 | Microfluidic devices fabri-cated in poly ( dimethylsiloxane ) for biological studies 显示文摘 | SAMUEL K S GEORGE M W | 2003 | Electrophoresis2003，，24： | 1 |
| 5 | The relationship between explana-tory style and posttraumatic growth after bereavement in a non-clinical sample显示文摘 | Samuel MYHO Chu K W Yiu J | 2008 | Death Studies2008，32，： | 1 |
| 6 | Percutaneous nephrolithotomy for caliceal diverticular calculi:a novel single stage approach显示文摘 | Samuel C K Ramsay L K William W T | 2005 | The Journal of Urology2005，173，： | 1 |
| 7 | Sorption dynamics of hydrophobic pollutants in sediment suspensions显示文摘 | Samuel W K Kenneth R M | 1985 | Environmental Toxicology and Chemistry1985，4，4： | 1 |
| 8 | An In- tegrated Gas Sensor Based on Tin Oxide Thin-fihn and Improved Micro-hotplate显示文摘 | Zhenan Tang Samuel K H Fung Darwin T W Wong | 1998 | Sensors and Actuators B 461998，，： | 1 |
| 9 | Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells:involvement of mitogen-activated protein kinases显示文摘 | Nagineni CN Samuel W Nagineni S Pardhasaradhi K Wiggert B Detrick B | 2003 | J Cell Physiol2003，197，： | 1 |
| 10 | Addressing the met- abolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling tech- niques 显示文摘 | SAMUEL K YIN W STEARNS RA | 2003 | J Mass Spectromet2003，38，3： | 1 |
| 11 | Production of alpha-1, 3-galactosyltransferase knockout pigs by nuclear transfer cloning显示文摘 | Lai L Kolber-Simonds D Park K W Cheong H T Greenstein J L Im G S Samuel M Bonk A Rieke A DayB N Murphy C N Carter D B Hawley R J Prather R S | 2002 | Science2002，295，5557： | 1 |
| 12 | Virchow-Robin spaces on magnetic resonance images:normative data,their dilatation,and a review of the literature显示文摘 | Samuel G S Chong W K Surtees R | 2006 | Neuroradiology2006，48，2： | 1 |
| 13 | An analysis of the Candida albicans gonome database for soluble secreted proteins using computer-based prediction algorithms显示文摘 | Samuel A Lee Steven W Sophien K | 2003 | Yeast2003，20，： | 1 |
| 14 | Navigating in the New Competitive Landscape:Building Strategic Flexibility and Comepetitive Advantage in the 21st Century 显示文摘 | A H Michael W K Barbara M D Samuel | 1998 | Academy of Management Executive1998，12，4： | 1 |
| 15 | Peripheral vascular effects of morphine in patients without pre-existing cardiac disease显示文摘 | Samuel I O Unni V K Dundee J W | 1977 | BrJ Anaesth1977，49，： | 1 |
| 16 | The formation and performance of auxetic textiles: part II: geometry and structural properties 显示文摘 | SAMUEL C U YONG K K STEVEN B W | 2011 | Journal of the Textile Institute2011，1025，： | 1 |
| 17 | Transforming growth factor - beta regulates stearoyl coenxyme A desaturase expression through a smad signalling pathway 显示文摘 | SAMUEL W NAGINENT C N KUTTY R K | 2002 | Journal Biological Chemistry2002，277，1： | 1 |
| 18 | Assessing the eco- nomic value of a world heritage site and willingness-to-pay determinants:A case of Changdeok Palace 显示文摘 | SAMUEL S K KEVIN K F W MIN C | 2007 | Tourism Management2007，28，： | 1 |
| 19 | Navigating in the new competitive landscape: Building strategic flexibility and competitive advantage in the 21st century显示文摘 | Michael A H Barbara W K Samuel M D | 1998 | Academy of Management Executive1998，12，4： | 1 |
| 20 | Effect of metal cathode reflectance on the exciton-dissciation efficiency in heterojunction organic solar cells显示文摘 | Pandey A K Shaw P E Samuel I D W | 2009 | Applied Physics Letters2009，，94： | 1 |
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