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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant 显示文摘 | Willner P Towell A Sampson D | 1987 | Psychopharmacology1987，93，3： | 1 |
| 3 | Real-time dispersion compensation in scanning interferometry显示文摘 | SMITH E D J ZVYAGIN A V SAMPSON D D | 2002 | Opt Lett2002，27，22： | 1 |
| 4 | Reduction of sucrose preference by chronic unpredictable mild stress,and its restoration by a tricyclic antidepressant显示文摘 | Willner P Towell A Sampson D | | 0，，： | 1 |
| 5 | Comparison of leaf area index estimates from tree allometrics and measured light interception显示文摘 | Smith F W Sampson D A Long J N | 1991 | Forest Science1991，37，6： | 1 |
| 6 | Photonic codedivision multiple-access communications显示文摘 | Sampson D D Pendock G J Griffin R A | 1997 | Fiber and Integrated Optics1997，16，： | 1 |
| 7 | Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant 显示文摘 | Willner P Towell A Sampson D | 1987 | Psychopharmacology( Berl)1987，93，3： | 1 |
| 8 | A successive approximation vector quantizer for wavelet transform image coding显示文摘 | da Silva E A B Sampson D G Ghanbari M | 1997 | IEEE Trans on Image Processing1997，5，2： | 1 |
| 9 | Regional in{luences of soil a- vailable water-holding capacity and climate, and leaf area index on simulated loblolly pine productivity显示文摘 | SAMPSON D A ALLEN H L | 1999 | Forest Ecology and Management1999，124，1： | 1 |
| 10 | Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant显示文摘 | Willner P Towell A Sampson D | 1987 | Psychophamlacology1987，93，3： | 1 |
| 11 | Reduction of sucrose preference by chronic unpredictable mildstress, and its restoration by a tricyclie antidepressant显示文摘 | Wiilenr P Towell A Sampson D | 1987 | Psychopharmacology1987，93，3： | 1 |
| 12 | Reduction of sucrose preference by chronic unpredictable mild stress and its restoration by a tricyclic antidepressant 显示文摘 | Winner P Towell A Sampson D | 1987 | Psychophannacology1987，93，3： | 1 |
| 13 | Reduction of glucose Prefer-ence by chronic mild unpredictable stress and its restoration by a trycyclic antidepressant显示文摘 | Willner P Towell A Sampson D | 1987 | Phychopharmacy1987，93，3： | 1 |
| 14 | Reduction of sucrose preference by chronic unpredictable mild stress and its restoration by atri-cyclic antidepressant 显示文摘 | Willner P Towell A Sampson D | 1987 | Psychopharmacology1987，93，3： | 1 |
| 15 | Tracking the rapid pace of GIS-related capabilities and their accessibility显示文摘 | SAMPSON B A DELGIUDICE G D | 2006 | Wildlife Society Bulletin2006，34，5： | 1 |
| 16 | Reduction of sucrospreference by chronicun predictable mildstress,and its restoration by atricycles antidepressant显示文摘 | Willner P Towell A Sampson D | 1987 | Psychopharmacology(S0033-3158)1987，93，3： | 1 |
| 17 | Reduction of sucross preference by chronic mild unpredictable stress and its restoration by a tricyclic antidepressant显示文摘 | Towell A Sampson D | 1987 | Psychopharmacology1987，93，： | 1 |
| 18 | Reduction of sucrose preference by chronic unpredictable mild stress, and its restora- tion by a tricyclic antidepressant显示文摘 | Willner P Towell A Sampson D | 1987 | Psychopharmacology1987，93，3： | 1 |
| 19 | Reduction of sucrose preference by chronic mild unpredictable stress and its restoration by a tricyclic antidepressant显示文摘 | Willner P Towell A Sampson D | 1987 | Psychopharmacology1987，93，1： | 1 |
| 20 | Reduction of sucrose preference by chronic unpredictable mild stress and its restoration by a tricyclic antidepressant 显示文摘 | Willner P Towell A Sampson D | 1987 | Psychopharmacology1987，93，3： | 1 |
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