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| 1 | Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia显示文摘AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(PE)outcomes.METHODS:Liver specimens were obtained at PE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and CD34.Liver biopsies from 35 organ donors were used as controls.Expression patterns were related to clinical data including age at PE,serum total and conjugated bilirubin concentration at the time of PE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological findings.RESULTS:Collagen 1(16.4%vs 4.5%,P<0.0001),α-SMA(17.9%vs 4.6%,P<0.0001)and CD34(4.9%vs 3.8%,P=0.017)were markedly overexpressed in BA patients compared with controls.Patients who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,P=0.024),α-SMA(20.4%vs 15.4%,P=0.009)and CD34(5.9%vs 4.0%,P=0.029)at PE compared with native liver survivors.CD34-positive microvessels were identified in the centrizonal region close to central vein in every BA patient.In majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic lobules.In controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the rest.The difference between BA patients and controls was significant(P<0.0001).Patients who developed esophageal varices by two years had significantly higher expression of CD34 at PE compared with patients without varices(5.6%vs 4.0%,P=0.019).Expression ofα-SMA(r=0.758,P<0.0001)and collagen 1(r=0.474,P=0.016),and the amount of CD34-positive microvessels(r=0.356,P=0.047)were related to patient age at PE.CONCLUSION:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasing PE age and relate to native liver survival and development of esophageal varices. | Janne S Suominen Hanna Lampela Pivi Heikkil Jouko Lohi Hannu Jalanko Mikko P Pakarinen | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Silicene structures on silver surfaces显示文摘 | Hanna Enriquez Sébastien Vizzini Abdelkader Kara Boubekeur Lalmi Hamid Oughaddou | 2012 | Journal of Physics: Condensed Matter2012，，： | 3 |
| 4 | Modeling Klamath River system operations for quantity and quality 显示文摘 | Campbell S G Hanna R B Flug M | 2001 | Journal of Water Resources Planning and Management2001，127，5： | 2 |
| 5 | Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism显示文摘 | Zanchi A Moczulski D K Hanna L S | | 0，，： | 2 |
| 6 | Adsorption of sulfonate on reservoir rocks显示文摘 | SOMASUNDARAN P HANNA H S | 1979 | Society of Petroleum Engineers Journal1979，19，4： | 1 |
| 7 | Anti-inflammatory properties of molecular hydrogen:investigation on parasite-induced liver inflammation显示文摘 | Gharib B Hanna S Abdallahi OMS | 2001 | C R Acad Sci III2001，324，8： | 1 |
| 8 | Survival update for the phase Ⅲ study of pemetrexed vs docetaxel in non-small cell lung cancer (NSCLC)显示文摘 | Demarinis F Paul S Hanna N | 2006 | J Clin Oncol2006，24，18： | 1 |
| 9 | Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency显示文摘 | Hanna J Markoulaki S Schorderet P | 2008 | Cell2008，133，2： | 1 |
| 10 | Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging显示文摘 | Hanna J?rnum Elena G. Steffensen Linda Knutsson Ernst-Torben Fründ Carsten Wiberg Simonsen S?ren Lundbye-Christensen Ajit Shankaranarayanan David C. Alsop Finn Taageh?j Jensen Elna-Marie Larsson | 2010 | Neuroradiology2010，，4： | 1 |
| 11 | ,Dose-response as-sessment of fetal testosterone production and gene expression levels inrat testes following in utero exposure to diethylhexyl phthalate, di-isobutyl phthalate, diisoheptyl phthalate > and diisononyl phthalate显示文摘 | HANNAS B R LAMBRIGHT C S FURR J | 2011 | Toxicological Sciences t2011，123，1： | 1 |
| 12 | Rotation of absorbing spheres in Laguerre-Gaussian beam显示文摘 | S H Simpson S Hanna | 2009 | JOSA A2009，26，1： | 1 |
| 13 | DNA methylation changes in whole blood is associated with exposure to the environmental contaralna nts, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF 显示文摘 | Hanna C W Bloom M S Robinson W P | 2012 | Human Reproduction2012，27，： | 1 |
| 14 | Soybean threshing mechanism development and testing显示文摘 | Femando S Hanna M Mesquita C | 2004 | Transactions of the ASAE2004，47，3： | 1 |
| 15 | Survival update for the phase Ⅲ study of pemetrexed vs docetaxel in non - small cell lung cancer (NSCLC) 显示文摘 | Demarinis F Paul S Hanna N etal | 2006 | Proc ASCO2006，7133，： | 1 |
| 16 | Antitumor interaction of short-course endostatin and ionizing radiation显示文摘 | Hanna NN SeetharalTl S Mauceri HJ | 2000 | Cancer J2000，6，5： | 1 |
| 17 | Orbital motion of optically trapped particles in Laguerre-Gaussian beams显示文摘 | S H Simpson S Hanna | 2010 | JOSA A2010，27，9： | 1 |
| 18 | Uncertainties in Air Quality Model Predictions显示文摘 | Hanna S R | 1993 | Bound Layer Meteorology1993，，62： | 1 |
| 19 | Intratumoral heterogeneity of HER -2/neu in breast cancer:a rare event显示文摘 | Hanna W Nofecb - Mozes S Kahn HJ | 2007 | Breast J2007，13，2： | 1 |
| 20 | Role of Rab9GTPase in facilitating receptor recruitment by TIP47显示文摘 | Carroll K S Hanna J Simon I | 2001 | Science2001，292，5520： | 1 |
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