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| 1 | Endocrine role of bone in the regulation of energy metabolism显示文摘Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function.Recently,an increasing number of studies have characterized the significance of bone as an endocrine organ,suggesting that bone-derived factors regulate local bone metabolism and metabolic functions.In addition,these factors can regulate global energy homeostasis by altering insulin sensitivity,feeding behavior,and adipocyte commitment.These findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis,treatment,and prevention of metabolic diseases such as osteoporosis,obesity,and diabetes mellitus.In this review,we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research. | Ruoyu Zhou Qiaoyue Guo Ye Xiao Qi Guo Yan Huang Changjun Li Xianghang Luo | 2021 | Bone Research2021，9，4： | 11 |
| 2 | The role and its mechanism of intermittent fasting in tumors:friend or foe?显示文摘Intermittent fasting(IF)is becoming a prevailing topic worldwide,as it can cause changes in the body’s energy metabolism processes,improve health,and affect the progression of many diseases,particularly in the circumstance of oncology.Recent research has shown that IF can alter the energy metabolism of tumor cells,thereby inhibiting tumor growth and improving antitumor immune responses.Furthermore,IF can increase cancer sensitivity to chemotherapy and radiotherapy and reduce the side effects of these traditional anticancer treatments.IF is therefore emerging as a promising approach to clinical cancer treatment.However,the balance between long-term benefits of IF compared with the harm from insufficient caloric intake is not well understood.In this article,we review the role of IF in tumorigenesis and tumor therapy,and discuss some scientific problems that remain to be clarified,which might provide some assistance in the application of IF in clinical tumor therapy. | Xu Zhao Jing Yang Ruoyu Huang Mengmeng Guo Ya Zhou Lin Xu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 3 | Application of Bronsted acid ionic liquids as green catalyst in the synthesis of 2-propanol with reactive distillation显示文摘Five Br?nsted acidic ionic liquids(ILs) were prepared and characterized by FT-IR,~1H NMR and ^(13)C NMR. Their catalytic activities for the synthesis of 2-propanol(IPOH) via transesterification of isopropyl acetate(IPAc) with methanol(Me OH) were investigated. Among all the tested ILs, [Ps-mim]HSO_4 performed best and was used as catalyst for further studies. The reaction kinetics were carried out to correlate the parameters in a homogeneous second order kinetic model. It has been found that there is close agreement between the calculated and experimental values. The high-pressure batch reactive distillation experimental apparatus was set up in order to enhance the conversion of IPAc. A high conversion of IPAc of 99.4% was obtained under the optimal reaction conditions. The catalyst [Ps-mim]HSO_4 can be recycled easily by a rotary evaporator and reused without any further treatment. The catalyst had been repeatedly used for four times and no obvious changes in the structure of catalyst could be observed. | Jinbei Yang Dongren Cai Ting Zeng Lihua Zhou Ling Li Ruoyu Hong Ting Qiu | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 3 |
| 4 | Influence of Low-velocity Impact on Damage Behavior of Carbon Fiber-reinforced Composites显示文摘A combination of experimental measurements and numerical analysis was utilized to study the low-velocity impact damage of domestic carbon fiber-reinforced composites(CFRCs).The results indicated that the low-velocity impact damage induced pits and longitudinal cracks on the front side,oblique cracks and delaminationin on the back side.The pit depth increased with the increasing impact energy.It was demonstrated that the numerical analysis strain history curve was similar to the experimentally measured strain history curve,which verified the accuracy of numerical analysis in which the Hashin failure criterion was used.The work provides basic data and theoretical basis for the promotion and application of the domestic carbon fiber,and demonstrates the feasibility of replacing imported carbon fibers with domestic carbon fibers. | 张小玉 ZHOU Ruoyu 陈建中 LV Yong CAO Dongfeng | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，3： | 3 |
| 5 | Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration显示文摘Irregular defects generated by trauma or surgery in orthopaedics practice were usually difficult to be fitted by the preformed traditional bone graft substitute. Therefore, the injectable hydrogels have attracted an increasing interest for bone repair because of their fittability and mini-invasivity. However, the uncontrollable spreading or mechanical failures during its manipulation remain a problem to be solved. Moreover, in order to achieve vascularized bone regeneration, alternatives of osteogenic and angiogenic growth factors should be adopted to avoid the problem of immunogenicity and high cost. In this study, a novel injectable self-healing hydrogel system (GMO hydrogel) loaded with KP and QK peptides had been developed for enhancing vascularized regeneration of small irregular bone defect. The dynamic imine bonds between gelatin methacryloyl and oxidized dextran provided the GMO hydrogel with self-healing and shear-thinning abilities, which led to an excellent injectability and fittability. By photopolymerization of the enclosed GelMA, GMO hydrogel was further strengthened and thus more suitable for bone regeneration. Besides, the osteogenic peptide KP and angiogenic peptide QK were tethered to GMO hydrogel by Schiff base reaction, leading to desired releasing profiles. In vitro, this composite hydrogel could significantly improve the osteogenic differentiation of BMSCs and angiogenesis ability of HUVECs. In vivo, KP and QK in the GMO hydrogel demonstrated a significant synergistic effect in promoting new bone formation in rat calvaria. Overall, the KP and QK loaded GMO hydrogel was injectable and self-healing, which can be served as an efficient approach for vascularized bone regeneration via a minimally invasive approach. | Runze Li Chen Zhou Jun Chen Haotian Luo Ruoyu Li Danying Chen Xuenong Zou Weicai Wang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 6 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 7 | Prevalent fecal contamination in drinking water resources and potential health risks in Swat, Pakistan显示文摘Fecal bacteria contaminate water resources and result in associated waterborne diseases.This study assessed drinking water quality and evaluated their potential health risks in Swat, Pakistan. Ground and surface drinking water were randomly collected from upstream to downstream in the River Swat watershed and analyzed for fecal contamination using fecal indicator bacteria(Escherichia coli) and physiochemical parameters(potential of hydrogen, turbidity, temperature, electrical conductivity, total dissolved solid, color, odor and taste). The physiochemical parameters were within their safe limits except in a few locations, whereas, the fecal contaminations in drinking water resources exceeded the drinking water quality standards of Pakistan Environmental Protection Agency(Pak-EPA),2008 and World Health Organization(WHO), 2011. Multivariate and univariate analyses revealed that downstream urbanization trend, minimum distance between water sources and pit latrines/sewerage systems, raw sewage deep well injection and amplified urban,pastures and agricultural runoffs having human and animal excreta were the possible sources of contamination. The questionnaire survey revealed that majority of the local people using 10–20 years old drinking water supply schemes at the rate of 73% well supply,13% hand pump supply, 11% spring supply and 3% river/streams supply, which spreads high prevalence of water borne diseases including hepatitis, intestinal infections and diarrhea, dysentery, cholera, typhoid fever, jaundice and skin diseases in children followed by older and younger adults. | Kifayatullah Khan Yonglong Lu Mian Abdal Saeed Hazrat Bilal Hassan Sher Hizbullah Khan Jafar Ali Pei Wang Herman Uwizeyimana Yvette Baninla Qifeng Li Zhaoyang Liu Javed Nawab Yunqiao Zhou Chao Su Ruoyu Liang | 2018 | Journal of Environmental Sciences2018，30，10： | 1 |
| 8 | Determination of reversible and irreversible contributions to the polarization and strain response of soft PZT using the partial unloading method 显示文摘 | Zhou Dayu Wang Ruoyu Kamlah Marc | 2010 | Journal of the European Ceramic Society2010，30，12： | 1 |
| 9 | Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy显示文摘Oral tyrosine kinase inhibitors(TKIs) against epidermal growth factor receptor(EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery. | Xiaohan Zhou Kun Shi Ying Hao Chengli Yang Ruoyu Zha Cheng Yi Zhiyong Qian | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，1： | 1 |
| 10 | p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis显示文摘Objective: Polycystic kidney disease(PKD) is the major cause of kidney failure and mortality in humans. It has always been suspected that the development of cystic kidney disease shares features with tumorigenesis, although the evidence is unclear.Methods: We crossed p53 mutant mice(p53N236S, p53S) with Werner syndrome mice and analyzed the pathological phenotypes.The RNA-seq, ss GSEA analysis, and real-time PCR were performed to dissect the gene signatures involved in the development of disease phenotypes.Results: We found enlarged kidneys with fluid-filled cysts in offspring mice with a genotype of G3mTerc^(-/-)WRN^(-/-)p53^(S/S)(G3TM).Pathology analysis confirmed the occurrence of PKD, and it was highly correlated with the incidence of tumorigenesis. RNA-seq data revealed the gene signatures involved in PKD development, and demonstrated that PKD and tumorigenesis shared common pathways, including complement pathways, lipid metabolism, mitochondria energy homeostasis and others. Interestingly, this G3TM PKD and the classical PKD1/2 deficient PKD shared common pathways, possibly because the mutant p53S could regulate the expression levels of PKD1/2, Pkhd1, and Hnf1b.Conclusions: We established a dual mouse model for PKD and tumorigenesis derived from abnormal cellular proliferation and telomere dysfunction. The innovative point of our study is to report PKD occurring in conjunction with tumorigenesis. The gene signatures revealed might shed new light on the pathogenesis of PKD, and provide new molecular biomarkers for clinical diagnosis and prognosis. | Haili Li Yongjin Zhang Juhua Dan Ruoyu Zhou Cui Li Rong Li Xiaoming Wu Sanjay Kumar Singh Jeffrey T.Chang Julun Yang Ying Luo | 2019 | Cancer Biology & Medicine2019，16，1： | 1 |
| 11 | Review on HVDC cable terminations显示文摘With modern power utilities going green by utilising renewable energy technologies and the development of the smart power grid,high-voltage direct current(HVDC)technologies become more and more important in the energy transmission.In particular,HVDC cable systems play a prominent role in undersea power transmission and offshore renewable energy integration.As an essential part of a complete HVDC cable system,the cable termination is one of the most critical components.The mathematical and physical background of HVDC cable systems is discussed and the development of various types of HVDC cable terminations is reviewed.Regarding the non-uniform field distribution,the influence of temperature on the non-linear conductivity is briefly discussed.Furthermore,faults of terminations caused by inappropriate installation and testing of cable systems are discussed. | Hanyu Ye Tobias Fechner Xianzhang Lei Yi Luo Mingyu Zhou Zhengyi Han Haitian Wang Qikai Zhuang Ruoyu Xu Duo Li | 2018 | High Voltage2018，3，2： | 1 |
| 12 | Atmospheric emissions of F, As, Se, Hg, and Sb from coal-fired power and heat generation in China显示文摘 | Jian Chen Guijian Liu Yu Kang Bin Wu Ruoyu Sun Chuncai Zhou Dun Wu | 2012 | Chemosphere2012，，： | 1 |
| 13 | Reduced graphene oxide-platinum nanoparticles composites based imprinting sensor for sensitively electrochemical analysis of 17β-estradiol显示文摘 | Tingting Wen Cheng Xue Yun Li Yang Wang Ruoyu Wang Junli Hong Xuemin Zhou Huijun Jiang | 2012 | Journal of Electroanalytical Chemistry2012，，： | 1 |
| 14 | Atmospheric emissions of F, As, Se, Hg, and Sb from coal-fired power and heat generation in China显示文摘 | Jian Chen Guijian Liu Yu Kang Bin Wu Ruoyu Sun Chuncai Zhou Dun Wu | 2012 | Chemosphere2012，，： | 1 |
| 15 | Label-free colorimetric nanosensor with improved sensitivity for Pb^2+ in water by using a truncated 8-17 DNAzyme显示文摘Water pollution accidents, such as the Flint water crisis in the United States, caused by lead contamination have raised concern on the safety of drinking water distribution systems. Thus, the routine monitoring of lead in water is highly required and demands efficient, sensitive, cost-effective, and reliable lead detection methods. This study reports a label-free colorimetric nanosensor that uses unmodified gold nanoparticles (AuNPs) as indicators to enable rapid and ultra-sensitive detection of lead in environmental water. The 8-17 DNAzyme was truncated in this study to facilitate the detachment of single-stranded DNA fragments after substrate cleavage in the presence of Pb「. The detached fragments were adsorbed over AuNPs and protected against salt concentration-induced aggregation. Accordingly, high Pb^2+ would result in rapid color change from blue to pink. The established sensing principle achieved a sensitive limit of detection of 0.2×10^-9mol/L Pb^2+. with a linear working range of two orders of magnitude from 0.5×10^-9mol/L to 5×10^-9mol/L. The selectivity of the nanosensor was demonstrated by evaluating the interfering metal ions. The developed nanosensor can serve as a substitute for the rapid analysis and monitoring of trace lead levels under the drinking water distribution system and even other environmental water samples. | Abdul Ghaffar Memon Xiaohong Zhou Yunpeng Xing Ruoyu Wang Lanhua Liu Mohsin Khan Miao He | 2019 | Frontiers of Environmental Science & Engineering2019，13，1： | 1 |
| 16 | The DDB1-DCAF2 complex is essential for B cell development because it regulates cell cycle progression显示文摘B cell development in the bone marrow is critical for producing numerous B cells that play an essential role in the adaptive immune response.B cells develop from common lymphoid progenitors(CLPs),which then differentiate through a series of stages,which include prepro-B cells,pro-B cells,pre-B cells,immature B cells,and mature B cells. | Zhonghui Xue Jing Guo Ruoyu Ma Lina Zhou Yixin Guo Yong Cang Hengyu Fan Jian Chen Wenbin Qian Lie Wang | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 17 | Magnetically driven microrobots moving in a flow:a review显示文摘Magnetically driven microrobots hold great potential to perform specific tasks more locally and less invasively in the human body.To reach the lesion area in vivo,microrobots should usually be navigated in flowing blood,which is much more complex than static liquid.Therefore,it is more challenging to design a corresponding precise control scheme.A considerable amount of work has been done regarding control of magnetic microrobots in a flow and the corresponding theories.In this paper,we review and summarize the state-of-the-art research progress concerning magnetic microrobots in blood flow,including the establishment of flow systems,dynamics modeling of motion,and control methods.In addition,current challenges and limitations are discussed.We hope this work can shed light on the efficient control of microrobots in complex flow environments and accelerate the study of microrobots for clinical use. | Jiamiao MIAO Xiaopu WANG Yan ZHOU Min YE Hongyu ZHAO Ruoyu XU Huihuan QIAN | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，11： | 0 |
| 18 | Circ RNA and ferroptosis in human disease:Insights for new treatments显示文摘Circular RNA(circ RNA),classified as a type of non-coding RNA,has gained significant attention in the field of biology due to its distinctive ring structure and functional properties.Recent research has provided evidence that specific circ RNAs have the ability to modulate disease progression through diverse mechanisms,one of which is by regulating cellular ferroptosis.Ferroptosis is a form of regulated cell death that is driven by iron dependency and lipid peroxidation,and extensive investigations have revealed a relationship between ferroptosis and disease development.In addition to evidence that both circ RNAs and ferroptosis exert critical roles in disease progression,circ RNAs have also been shown to actively mediate the process of ferroptosis.The relationship between circ RNAs and ferroptosis therefore influences disease progression and offers novel targets for disease treatment.By directly or indirectly modulating the expression of circ RNAs that regulate the expression of ferroptosisrelated proteins,it may be possible to impact disease progression by promoting or inhibiting ferroptosis.Current research indicates such approaches may hold significant value in a wide variety of common diseases across physiological systems.This review comprehensively summarizes the findings of recent studies investigating the roles of circ RNAs in the regulation of ferroptosis in various diseases. | Ruoyu Liu Yun Zhou Yongtong Cao | 2023 | Animal Models and Experimental Medicine2023，6，6： | 0 |
| 19 | Unraveling the heterogeneity of solid electrolyte interphase kinetically affecting lithium electrodeposition on lithium metal anode显示文摘The stability and uniformity of solid electrolyte interphase(SEI)are critical for clarifying the origin of capacity fade and safety issues for lithium metal anodes(LMA).However,understanding the interplay of SEI heterogeneity and Li electrodeposition is limited by the coupling of complex electrochemistry and mechanics processes.Herein,the correlation between the SEI failure behavior and Li deposition morphology is investigated through a quantitative electrochemical-mechanical model.The local deformation and stress of SEI during Li electrodeposition identify that the heterogeneous interface between different components first fails.Compared with the well-known mechanical strength,component uniformity plays the most important role in the initial SEI failure and uneven Li deposition,and a relative component uniformity(p>0.01)represents a proper balance to ensure the stability of the naturally heterogeneous SEI.Furthermore,the component regulation of SEI via the designed electrolyte experimentally demonstrates that improving component uniformity benefits SEI stability and the uniform Li electrodeposition for LMA,thereby increasing the capacity by~20%after 300 cycles.These fundamental understandings and proposed strategy can be not only used to guide the SEI optimization via the electrolyte regulation,but also extended to the rational designs of artificial SEI for high-performance LMA. | Mengyuan Zhou Yaqi Liao Longhui Li Ruoyu Xiong Guancheng Shen Yifu Chen Tianlun Huang Maoyuan Li Huamin Zhou Yun Zhang | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 20 | Experiments on the characteristics of underwater electrical wire explosions for reservoir stimulation显示文摘Underwater shock waves generated by pulsed electrical discharges are an effective,economical,and environmentally friendly means of stimulating reservoirs,and this technology has received much attention and intensive research in the past few years.This paper reviews the main results of recent work on underwater electrical wire explosion(UEWE)for reservoir stimulation.Aplatform is developed for microsecond singlewire explosions in water,and diagnostics based on a voltage probe,current coil,pressure probe,photodiode,and spectrometer are used to characterize the UEWE process and accompanying shock waves.First,the UEWE characteristics under different discharge types are studied and general principles are clarified.Second,the shock-wave generation mechanism is investigated experimentally by interrupting the electrical energy injection into the wire at different stages of the wire-explosion process.It is found that the vaporization process is vital for the formation of shock waves,whereas the energy deposited after voltage collapse has only a limited effect.Furthermore,the relationships between the electrical-circuit and shock-wave parameters are investigated,and an empirical approach is developed for estimating the shock-wave parameters.Third,how the wire material and water state affect the wire-explosion process is studied.To adjust the shock-wave parameters,a promising method concerning energetic material load is proposed and tested.Finally,the fracturing effect of the pulsed-discharge shock waves is discussed,as briefly are some of the difficulties associated with UEWE-based reservoir stimulation. | Ruoyu Han Jiawei Wu Haibin Zhou Yongmin Zhang Aici Qiu Jiaqi Yan Weidong Ding Chen Li Chenyang Zhang Jiting Ouyang | 2020 | Matter and Radiation at Extremes2020，5，4： | 0 |
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