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| 1 | Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system显示文摘Cannabinoid receptor CB2(CB2R)is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases,such as Alzheimer’s disease,amyotrophic lateral sclerosis,and ischemic stroke.The advent of positron emission tomography(PET)using CB2R radiotracers has enabled the visualization of CB2R distribution in vivo in animal models of central nervous system inflammation,however translation to humans has been less successful.Several novel CB2R radiotracers have been developed and evaluated to quantify microglial activation.In this review,we summarize the recent preclinical and clinical imaging results of CB2R PET tracers and discuss the prospects of CB2R imaging using PET. | Ruiqing Ni Linjing Mu Simon Ametamey | 2019 | Acta Pharmacologica Sinica2019，40，3： | 2 |
| 2 | Hybrid magnetic resonance and optoacoustic tomography(MROT) for preclinical neuroimaging显示文摘Multi-modal imaging is essential for advancing our understanding of brain function and unraveling pathophysiological processes underlying neurological and psychiatric disorders.Magnetic resonance(MR)and optoacoustic(OA)imaging have been shown to provide highly complementary contrasts and capabilities for preclinical neuroimaging.True integration between these modalities can thus offer unprecedented capabilities for studying the rodent brain in action.We report on a hybrid magnetic resonance and optoacoustic tomography(MROT)system for concurrent noninvasive structural and functional imaging of the mouse brain.Volumetric OA tomography was designed as an insert into a high-field MR scanner by integrating a customized MR-compatible spherical transducer array,an illumination module,and a dedicated radiofrequency coil.A tailored data processing pipeline has been developed to mitigate signal crosstalk and accurately register image volumes acquired with T1-weighted,angiography,and blood oxygenation level-dependent(BOLD)sequences onto the corresponding vascular and oxygenation data recorded with the OA modality.We demonstrate the concurrent acquisition of dual-mode anatomical and angiographic brain images with the scanner,as well as real-time functional readings of multiple hemodynamic parameters from animals subjected to oxygenation stress.Our approach combines the functional and molecular imaging advantages of OA with the superb soft-tissue contrast of MR,further providing an excellent platform for cross-validation of functional readings by the two modalities. | Zhenyue Chen Irmak Gezginer Mark-Aurel Augath Wuwei Ren Yu-Hang Liu Ruiqing Ni Xose Luis Dean-Ben Daniel Razansky | 2022 | Light(Science & Applications)2022，11，12： | 0 |
| 3 | PanGu Drug Model: learn a molecule like a human显示文摘Dear Editor,Recent achievements in large-scale pre-trained models like GPT-3 and PanGu-α have demonstrated astounding performances in many downstream tasks of natural language processing (NLP),confirming AI to be user-oriented for even industrial applications.Deep learning has been recognized as the most promising technology for pharmaceuticals,a powerful molecule pre-trained model that could economize researchers’tons of time.For the strategic application of AI capabilities to the drug discovery field,we pre-trained a model called PanGu Drug Model with 1.7 billion small molecules from ZINC20 (Irwin et al.,2020),DrugSpaceX(Yang et al.,2021),and UniChem (Chambers et al.,2013). | Xinyuan Lin Chi Xu Zhaoping Xiong Xinfeng Zhang Ningxi Ni Bolin Ni Jianlong Chang Ruiqing Pan Zidong Wang Fan Yu Qi Tian Hualiang Jiang Mingyue Zheng Nan Qiao | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 4 | Advances in non-invasive imaging of proteinopathies in animal models of neurodegenerative diseases显示文摘Neurodegenerative diseases,including Alzheimer's disease(AD),frontotemporal dementia,Parkinson's disease,and dementia with Lewy bodies,represent tremendous unmet clinical needs.A common feature of these diseases is the aberrant cerebral accumulation of pathological protein aggregates,affecting selectively vulnerable circuits in a disease-specific pattern.Earlier studies have established a relationship between abnormal aggregation and neuronal dysfunction or loss,suggesting multifactorial pathogenesis mechanisms in these neurodegenerative disorders. | Lei Cao Bin Ji Ruiqing Ni | 2024 | Neural Regeneration Research2024，19，10： | 0 |
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