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| 1 | Development of SSR markers from ESTs of gramineous species and their chromosome location on wheat显示文摘407,663 的一个总数表示了小麦,大麦,玉米,米饭,和蜀黍的顺序标签(EST ) ,从 GenBank/dbEST 获得了,被用来寻找简单顺序重复(SSR ) 。10,253 EST-SSRs 的一个总数,说明了 2.52% 所有 EST,被识别。用教材首相 5.0, 1367 EST-SSR 教材对被设计,哪个 715 与高质量被综合。 715 教材对在五庄稼在一样的 PCR 条件,和有效教材对下面在小麦,米饭,玉米,棉花,和大豆上被测试是 500 (69.93%), 383 (53.57%), 452 (63.22%), 357 (49.93%),并且 388 (56.27%)分别地。这显示了在扩及远距离的种类之间的 EST-SSR 标记的高可转移性。另外,有 240 loci 的 139 EST-SSR 教材对在由使用小麦的中国春天 nulli-tetrasomic 线的所有 21 个小麦染色体上是局部性的。 | Linzhi Li Junjun Wang Ying Guo Fangshan Jiang Yunfeng Xu Yingying Wang Haitao Pan Guanzhu Han Ruijun Li Sishen Li | 2008 | Progress in Natural Science:Materials International2008，18，12： | 25 |
| 2 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 3 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 4 | Timing Advanced Estimation Algorithm of Low Complexity Based on DFT Spectrum Analysis for Satellite System显示文摘In satellite mobile communication system, relative movement of the satellite and the terminal will cause a large Doppler offset. Timing advanced estimation with Zadoff-Chu sequence is sensitive to the frequency offset. When the frequency offset is larger than one times subcarrier spacing, the value of peak cannot be detected at the receiving end. To suppress the larger Doppler frequency shift, this paper proposes a novel timing advanced estimation scheme(TAE-MCD) for satellite communication system. In this algorithm, t r a n s m i t t e d s i g n a l i s d i v i d e d i n t o Z C sequence and its conjugate sequence. Using multiplication and DFT operation to find the estimated peak at the receiving end, and make subtraction with the obtained sequences at last. The scheme can not only inhibit the adverse effects of large Doppler frequency shift in timing estimation effectively, but also reduce the computational complexity at the receiving end and improve the work efficiency of the hardware. Simulations results show that TAEMCD outperform the existing timing advanced estimation methods, on the condition of no additional time and frequency resource are needed. | HE Yizhou CUI Gaofeng LI Pengxu CHANG Ruijun WANG Weidong | 2015 | China Communications2015，12，4： | 4 |
| 5 | Acetytation of ACAP4 regutates CCL18-elicited breast cancer cell migration and invasion显示文摘Tumor metastasis represents the main causes of cancer-related death.Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis,but the underlying mechanisms remain less clear.Here, we show that ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation.CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation.ACAP4 physically interacts with PCAF and is a cognate substrate of PCAF during CCL18 stimulation.The acetylation site of ACAP4 by PCAF was mapped to Lys311 by mass spectrometric analyses.Importantly,dynamic acetylation of ACAP4 is essential for CCL18-induced breast cancer cell migration and invasion,as overexpression of the persistent acetylation-mimicking or nonacetylatable ACAP4 mutant blocked CCL18-elicited cell migration and invasion.Mechanistically,the acetylation of ACAP4 at Lys311 reduced the lipid-binding activity of ACAP4 to ensure a robust and dynamic cycling of ARF6-ACAP4 complex with plasma membrane in response to CCL18 stimulation.Thus,these results present a previously undefined mechanism by which CCL18-elicited acetylation of the PH domain controls dynamic interaction between ACAP4 and plasma membrane during breast cancer cell migration and invasion. | Xiaoyu Song Wei Liu Xiao Yuan Jiying Jiang Wanjuan Wang McKay Mullen Xuannv Zhao Yin Zhang Fusheng Liu Shihao Du Adeel Rehman Ruijun Tian Jian Li Andra Frost Zhenwei Song Hadiyah-Nicole Green Calmour Henry Xing Liu Xia Ding Dongmei Wang Xuebiao Yao | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 6 | Separation of injectable salidroside by column chromatography of macroporous resins for treating myocardial ischemia显示文摘The objective of the present study is to develop a method for large-scale separating and purifying salidroside from rhodiola kirilowii roots and for preparing injectable medicinal ingredient.Crude extract of salidroside was prepared by water-ethanol system,and purified by column chromatography of macroporous resins.Static adsorption and desorption studies were performed on six kinds of macroporous resins,and SP825 resin was chosen,followed by optimizing process parameters.The optimum sample volume,feed concentration,ratio of diameter to height,and feeding flow rate were 1.5 bed volumes(BV),15 mg/mL,1:10 and 1 BV/h,respectively.Dynamic desorption was performed consecutively with 8 BV of distilled water,3 BV of 5% ethanol and 8 BV of 10% ethanol at a flow rate of 2 BV/h.After three cycles in separating 3.5 tons of rhodiola kirilowii roots,salidroside purity was increased from 3.4% in the crude extract to 93.6% in purified salidroside product.This study provides a novel method to separate salidroside for injectable use. | JU RuiJun HUANG RenJie ZHOU Jia LI RuoJing ZHOU Peng ZHANG ZaoHua XIANG FeiJun XU DongJin LIU WeiXiang MA XingTian ZHANG Qiang LU WanLiang | 2012 | Science China Chemistry2012，55，7： | 2 |
| 7 | Genetic diversity of wild barley (Hordeum vulgare ssp. spontaneum) and its utilization for barley improvement显示文摘Wild barley(Hordeum vulgare spp.spontaneum) is the undisputed progenitor of cultivated barley and offers considerable potential as a genetic resource for barley improvement.Naturally occurring populations are distributed primarily across the Fertile Crescent,but secondary areas of diversity are also found in central Asia and Tibet.The pattern of its genetic diversity is non-random,and is structured on a global,regional and local scale.On a global scale,diversity follows ecogeography,while on a regional and local scale,it is more strongly determined by ecology.Populations growing in areas where the climate is unreliable and/or the soil is heterogeneous tend to retain the most diversity.A large number of accessions are currently conserved ex situ,but a high proportion of these have originated from the Fertile Crescent.Given the likelihood of future climate change,conserving germplasm both in situ and ex situ in the various regions where the species' currently existing is a research priority.The value of H.vulgare spp.spontaneum for the improvement of cultivated barley lies largely in its potential contribution to the levels of attainable pathogen resistance and abiotic stress tolerance. | XiaoYing Ma Chao Li AiDong Wang RuiJun Duan GenLin Jiao Eviatar Nevo GuoXiong Chen | 2012 | Research in Cold and Arid Regions2012，4，6： | 2 |
| 8 | Facile fabrication of amphoteric semi-interpenetrating network membranes for vanadium flow battery applications显示文摘For improvement of vanadium redox flow battery(VRB) performance, novel amphoteric semiinterpenetrating membranes(ASIPN) were prepared using poly(ether ether ketone)(PEEK) and polysulfone(PSf), the former bearing sulfonic groups and the latter imidazolium. These two groups form ionic crosslinks between PEEK and PSf; meanwhile, covalent cross links were built between PSf chains with addition of N-(3-aminopropyl)-imidazole. The amphoteric nature of the membrane allows facile proton and anion transport; the IPN structure and the presence of imidazolium cation effectively suppress vanadium ion crossover through the membrane. Therefore, the ASIPN based VRBs show higher Coulombic efficiency and energy efficiency than that assembled with pristine SPEEK and Nafion 212 membranes. Our work demonstrates that the ASIPN membranes are promising for VRB applications. | Ruijun Gan Yanjiao Ma Shanshan Li Fengxiang Zhang Gaohong He | 2018 | Journal of Energy Chemistry2018，27，4： | 2 |
| 9 | Study on Assessment of Mine Environments显示文摘我的环境评估是我的关键环境学习。根据矿的特征环境问题,他们被分类进(1 ) 三个浪费问题,(2 ) 扎根了失真,(3 ) 在矿排水之中的矛盾,水供应,生态的环境,(4 ) desertification,并且(5 ) 土壤侵蚀。评估是我的基础环境问题分类和调查,我的环境康复,和构造的信息系统能被用于评估技术的随后的研究。对 5 种矿的一个合成评价环境问题能被划分成单个因素或多因素合成评价;当时由时间的观点,矿环境评价能作为历史的评价,当前的地位评价和预报评价被分类。 | WU Qiang LI Wei LI Ruijun | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 2 |
| 10 | Random access preamble design based on time pre-compensation for LTE-satellite system显示文摘Because of the integration of long term evolution(LTE) technology and mobile satellite communication systems, uplink access technology for LTE-based geo-stationary earth orbit(GEO) satellite has become a popular research topic for satellite system. In order to solve the problem of unreasonable design for physical random access channel(PRACH) signal structure and reduce the effect of time uncertainty, this paper proposes a novel random access preamble based on time pre-compensation(TPC) for LTE-Satellite(LTE-S) system. In this scheme, by applying the method of non-linear least squares, the user terminal(UT) can use the receiving power to estimate the communication round trip delay(RTD) and based on the transmission delay of the beam center and the satellite, RTD can be compensated before transmission. Therefore, the preamble length and duration can be reduced without related to the maximum of RTD. In order to verify the performance of the scheme, the MATLAB is used to build a test system. The simulation results show that the proposed preamble satisfies the requirements of LTE-S system, and the better performance than previous researches is obtained. | He Yizhou Cui Gaofeng Li Pengxu Chang Ruijun Wang Weidong | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，3： | 2 |
| 11 | Effects of High Pressure Treatment on Microstructure and Electrical Conductivity of CuCrAI Alloy显示文摘 | Xuemei Yang Jingrui Cai Guolong Li Jianhua Liu Ruijun Zhang | 2012 | 材料科学与工程(中英文A版)2012，2，5： | 1 |
| 12 | Monoclonal antibody based Dot-ELISA and indirect fluorescence antibody technique for detecting Edwardsiella ictaluri infection in yellow catfish (Pelteobagrus fulvidraco)显示文摘Edwardsiella ictaluri is known as the etiological agent of Red-head disease of yellow catfish(Pelteobagrus fulvidraco),and is the cause of heavy economic losses in the aquaculture industry.In this study,a DotEnzyme Linked Immunosorbent Assay(Dot-ELISA)and an Indirect Fluorescence Antibody technique(IFAT)for detecting Edwardsiella ictaluri were developed by using a monoclonal antibody,5D11.For DotELISA,the working dilutions of 5D11 and the secondary antisera(enzyme-labeled goat anti-mouse Ig)were 1:320 dilution and 1:3000 dilution,respectively.For IFAT,the working dilutions of 5D11 and goatanti-mouse Ig conjugated with fluorescein isothiocyanate were as respectively 1:80 and 1:256.Both of the methods established were highly sensitivity(Minimum detectable concentration,5107 CFU/mL)and had a high degree of accuracy(positive rate was 100%for both artificial infected fish and spontaneous diseased Pelteobagrus fulvidraco).The two reliable methods developed have high potential for quick and efficient detection of Edwardsiella ictaluri in aquaculture production units. | Ruijun Li Hua Huang Xianyu Zhang Shigen Ye Qiang Li | 2017 | Aquaculture and Fisheries2017，2，5： | 1 |
| 13 | Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE显示文摘Dear Editor,Previous studies have proved that regulatory T cell(Treg)insufficiency contributed to the development of autoimmune conditions including systemic lupus erythematosus(SLE).Conventional immunosuppressive treatment was reported to downregulate beneficial Tregs together with pathogenic effector immune cells,which may impede a rapid achievement of optimal therapeutic effects. | Haotian Zhou Xiaozhen Zhao Ruijun Zhang Miao Miao Wenwen Pei Zijun Li Yimin Li Jing He Zhanguo Li Xiaolin Sun | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 14 | Novel Risk Score to Predict Pneumonia After Acute Ischemic Stroke显示文摘 | Ruijun Ji Haipeng Shen Yuesong Pan Panglian Wang Gaifen Liu Yilong Wang Hao Li Yongjun Wang | 2013 | Stroke2013，，5： | 1 |
| 15 | The theory and experiment of very-long-wavelength 256×1 GaAs/Al_(x)Ga_(1-x)As quantum well infrared detector linear arrays显示文摘The 256×1 linear array of multiple quantum wells infrared photodetector (QWIP) is designed and fabricated for the peak response wavelength at λP=14.6 μm. The response spectral width is bigger than 2.2 μm. The two-dimensional (2D) diffractive coupling grating has been formed on the top QWIP photosensitive pixel for coupling the infrared radiation to the infrared detective layers. The performance of the device at VB=3 V and T=45 K has the responsibility 4.28×10-2 (A/W), the blackbody detectivity Db*=5.14×109 (cm·Hz1/2/W), and the peak detectivity Dλ*=4.24× 1010 (cm·Hz1/2/W). The sensor pixels are connected with CMOS read out circuit (ROC) hybridization by indium bumps. When integral time is 100 μs, the linear array has the effective pixel of QWIP FPA Nef of 99.2%, the average responsibility (V/W) of 3.48×106 (V/W), the average peak detectivity Dλ* of 8.29×109 (cm·Hz1/2/W), and the non-uniformity UR of 5.83%. This device is ready for the thermal image application. | GUO FangMin LI Ning XIONG DaYuan ZHEN HongLou XU XiangYan HOU Ying DING RuiJun LU Wei HUANG Qi ZHOU JunMing | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，7： | 1 |
| 16 | Effects of pretreatment of natural bacterial source and raw material on fermen- tative biohydrogen production显示文摘 | WANG Yubo LI Ruijun LI Weiwei | 2012 | Int J Hydrogen Energy2012，371，： | 1 |
| 17 | Adsorption of chromium(III), mercury(II) and lead(II) ions onto 4-aminoantipyrine immobilized bentonite显示文摘 | Qihui Wang Xijun Chang Dandan Li Zheng Hu Ruijun Li Qun He | 2010 | Journal of Hazardous Materials2010，，2： | 1 |
| 18 | Chemically-modified activated carbon with ethylenediamine for selective solid-phase extraction and preconcentration of metal ions显示文摘 | Zhenhua Li Xijun Chang Xiaojun Zou Xiangbing Zhu Rong Nie Zheng Hu Ruijun Li | 2008 | Analytica Chimica Acta2008，，2： | 1 |
| 19 | Research progress on resource utilization of leather solid waste显示文摘Leather making is the process of converting raw hides into leather.Amounts of solid waste containing hazardous and high value components are generated during this process.Therefore,the elimination of the potential pollution and resource utilization of leather solid waste are the primary research hotspots.Herein,we comprehensively review the recent advances in the resource utilization of leather solid waste generated from chrome tanning including the utilization of tannery hair waste,untanned solid waste,chrome-containing leather solid waste,tannery sludge and finished leather waste,emphasizing on the general and novel utilization approaches.Finally,the remaining challenges and perspectives were summarized,in order to accelerate the development of resource utilization of leather solid waste. | Yanchun Li Ruijun Guo Wenhui Lu Deyi Zhu | 2019 | Journal of Leather Science and Engineering2019，1，1： | 1 |
| 20 | Interrelationship Among Common Medical Complications After Acute Stroke: Pneumonia Plays an Important Role显示文摘 | Ruijun Ji David Wang Haipeng Shen Yuesong Pan Gaifen Liu Penglian Wang Yilong Wang Hao Li Yongjun Wang | 2013 | Stroke2013，，12： | 1 |
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