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| 1 | Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica显示文摘OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine. | Zhao Chongjun Tian Jinghuan Wang Jinfeng Feng Yaru Ni Yuanyuan Fan Jiaojiao Wang Chunmei Cao Dan Zou Qinwen Ma Zhiqiang Lin Ruichao | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 9 |
| 2 | Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration显示文摘Local lactate accumulation greatly hinders tissue repair and regeneration under ischemic condition.Herein,an injectable microsphere(MS@MCL)for local lactate exhaustion was constructed by grafting manganese dioxide(MnO_(2))-lactate oxidase(LOX)composite nanozyme on microfluidic hyaluronic acid methacrylate(HAMA)microspheres via chemical bonds,achieving a long-term oxygen-promoted lactate exhaustion effect and a long half-life in vivo.The uniform and porous microspheres synthesized by microfluidic technology is beneficial to in situ injection therapy and improving encapsulation efficiency.Furthermore,chemical grafting into HAMA microspheres through amide reactions promoted local enzymatic concentration and activity enhancement.It was showed that the MS@MCL eliminated oxidative and inflammatory stress and promoted extracellular matrix metabolism and cell survival when co-cultured with nucleus pulposus cells(NPCs)in vitro.In the rat degenerative intervertebral disc model caused by lactate injection,MS@MCL showed a long-term therapeutic effect in reducing intervertebral height narrowing and preventing extracellular matrix(ECM)degradation as well as inflammatory damage in vivo.Altogether,this study confirms that this nanozyme-functionalized injectable MS@MCL effectively improves the regenerative and reparative effect in ischemic tissues by disposing of enriched lactate in local microenvironment. | Jieliang Shen Ao Chen Zhengwei Cai Zhijie Chen Ruichao Cao Zongchao Liu Yuling Li Jie Hao | 2022 | Bioactive Materials2022，7，6： | 2 |
| 3 | Energy-Efficient Deployment of Water Quality Sensor Networks显示文摘Water quality sensor networks are promising tools for the exploration of oceans.Some key areas need to be monitored effectively.Water quality sensors are deployed randomly or uniformly,however,and understanding how to deploy sensor nodes reasonably and realize effective monitoring of key areas on the basis of monitoring the whole area is an urgent problem to be solved.Additionally,energy is limited in water quality sensor networks.When moving sensor nodes,we should extend the life cycle of the sensor networks as much as possible.In this study,sensor nodes in non-key monitored areas are moved to key areas.First,we used the concentric circle method to determine the mobile sensor nodes and the target locations.Then,we determined the relationship between the mobile sensor nodes and the target locations according to the energy matrix.Finally,we calculated the shortest moving path according to the Floyd algorithm,which realizes the redeployment of the key monitored area.The simulation results showed that,compared with the method of direct movement,the proposed method can effectively reduce the energy consumption and save the network adjustment time based on the effective coverage of key areas. | Qian Sun Zhiping Shen Jinglin Liang Xiaoyi Wang Jiping Xu Li Wang Huiyan Zhang Jiabin Yu Ning Cao Ruichao Wang | 2021 | Computers, Materials & Continua2021，，9： | 0 |
| 4 | Energy-Efficient Routing Algorithm Based on Small-World Characteristics显示文摘Water quality sensor networks are widely used in water resource monitoring.However,due to the fact that the energy of these networks cannot be supplemented in time,it is necessary to study effective routing protocols to extend their lifecycle.To address the problem of limited resources,a routing optimization algorithm based on a small-world network model is proposed.In this paper,a small-world network model is introduced for water quality sensor networks,in which the short average path and large clustering coefficient of the model are used to construct a super link.A short average path can reduce the network’s energy consumption,and a large coefficient can improve its fault-tolerance ability.However,the energy consumption of the relay nodes near the heterogeneous node is too great,and as such the energy threshold and non-uniform clustering are constructed to improve the lifecycle of the network.Simulation results show that,compared with the low-energy adaptive clustering hierarchy routing algorithm and the best sink location clustering heterogeneous network routing algorithm,the proposed improved routing model can effectively enhance the energy-utilization.The lifecycle of the network can be extended and the data transmission amount can be greatly increased. | Qian Sun Gongxue Cheng Xiaoyi Wang Jiping Xu Li Wang Huiyan Zhang Jiabin Yu Ning Cao Ruichao Wang | 2021 | Computers, Materials & Continua2021，，11： | 0 |
| 5 | An analysis of the transcriptional landscape in hypoxia-treated primary nucleus pulposus cells显示文摘Intervertebral disc degeneration(IDD)is the main cause of lower back pain.Lower back pain places a huge burden on society,and all current treatments for IDD cannot restore the original function of the intervertebral disc.Proposing new treatments for IDD requires clarifying the mechanisms of IDD.Physiological hypoxia is an important feature of the nucleus pulposus because of its special anatomical structure.Using RNA sequencing(RNA-seq),we obtained the whole transcriptome of nucleus pulposus cells(NPCs)under hypoxia and hypoxia-inducible factor(HIF1A)deletion.Results demonstrated possible effects of oxygen concentration and HIF1A on NPCs.In addition,our results showed that hypoxia can affect lipid metabolism in NPCs. | Zhicai Peng Zhuo Wang Shuaichi Guo Bing Tan Ruichao Cao Shengqiang Cheng Jun Chen Chunwang Xie Dehong Mao Zhenming Hu | 2024 | Genes & Diseases2024，11，2： | 0 |
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