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| 1 | Can tranexamic acid change preoperative anemia management during total joint arthroplasty?显示文摘AIM: To investigate the postoperative transfusion and complication rates of anemic and nonanemic total joint arthroplasty patients given tranexamic acid(TXA).METHODS: A cross-sectional prospective study was conducted of primary hip and knee arthroplasty cases performed from 11/2012 to 6/2014. Exclusion criteria included revision arthroplasty, bilateral arthroplasty, acute arthroplasty after fracture, and contraindication to TXA. Patients were screened prior to surgery, with anemia was defined as hemoglobin of less than 12 g/d L for females and of less than 13 g/d L for males. Patients were divided into four different groups, based on the type of arthroplasty(total hip or total knee) and hemoglobin status(anemic or nonanemic). Intraoperatively, all patients received 2 g of intravenous TXA during surgery. Postoperatively, allogeneic blood transfusion(ABT) was directed by both clinical symptomsand relative hemoglobin change. Complications were recorded within the first two weeks after surgery and included thromboembolism, infection, and wound breakdown. The differences in transfusion and complication rates, as well as the relative hemoglobin change, were compared between anemic and nonanemic groups.RESULTS: A total of 232 patients undergoing primary joint arthroplasty were included in the study. For the total hip arthroplasty cohort, 21%(18/84) of patients presented with preoperative anemia. Two patients in the anemic group and two patients in the nonanemic group needed ABTs; this was not significantly different(P = 0.20). One patient in the anemic group presented with a deep venous thromboembolism while no patients in the nonanemic group had an acute complication; this was not significantly different(P = 0.21). For nonanemic patients, the average change in hemoglobin was 2.73 ± 1.17 g/d L. For anemic patients, the average change in hemoglobin was 2.28 ± 0.96 g/d L. Between the two groups, the hemoglobin difference of 0.45 g/d L was not significant(P = 0.13). For the total knee arthroplasty cohort, 18%(26/148) of patients presented with preoperative anemia. No patients in either group required a blood transfusion or had an acute postoperative complication. For nonanemic patients, the average change in hemoglobin was 1.85 ± 0.79 g/d L. For anemic patients, the average change in hemoglobin was 1.09 ± 0.58 g/d L. Between the two groups, the hemoglobin difference of 0.76 g/d L was significant(P < 0.001). CONCLUSION: TXA administration results in low transfusion and complication rates and may be a useful adjunct for TJA patients with preoperative anemia. | Duy L Phan Joseph B Rinehart Ran Schwarzkopf | 2015 | World Journal of Orthopedics2015，6，7： | 5 |
| 2 | Structure and biosynthesis of toxins from bluegreen algae (cyanobacteria)显示文摘 | RINEHART K L NAMIKOSHI M CHIO B W | 1994 | Journal of Applied Phycology1994，6，： | 1 |
| 3 | Identification and preparation of damavaricins,biologically active precursors of streptovaricins显示文摘 | RINEHART K L ANTOSZ F J DESHMUKH P V | 1976 | J Antibiot1976，29，2： | 1 |
| 4 | Pharmacokinetic actions of exendin- 4 in the rat: comparison with glucagon-like peptide-1 显示文摘 | Parkes D Jodka C Smith P Nayak S Rinehart L Gingerich R | 2001 | Drug Dev Res2001，53，2： | 1 |
| 5 | Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate 显示文摘 | Rinehart K L Gloer J B Cook J C | 1981 | J Am Chem Soe1981，103，7： | 1 |
| 6 | Structures of the didemnins,antiviral and cytotoxic depsipeptides from a carib bean tunicate显示文摘 | Rinehart K L Gloer J B Cook J C | 1981 | J Am Chem Soc1981，103，7： | 1 |
| 7 | Evaluation of fetal protection against experimental infection with type 1 and type 2 bovine viral diarrhea virus after vaccination of the dam with a bivalent modified live virus vaccine显示文摘 | Fairbanks K K Rinehart C L Ohnesorge W C | | 0，，12： | 1 |
| 8 | Chemistry of the ansamvcin antibiotics 显示文摘 | Rinehart K L Jr Shield L S | 1976 | Fortschr Chem Org Naturst1976，33，： | 1 |
| 9 | Estrogen and progesterone receptors in non-small cell lung cancer in 248 consecutive patients who underwent surgical reseetion显示文摘 | Di Nunno L Lareson L G Rinehart JJ | 2000 | Arch Pat hol Lab Med2000，124，10： | 1 |
| 10 | Remote sensing of stripe patch and dillar spot on creeping bentgrass and annual bluegrass turfusing visible and near-infrared spectroscopy显示文摘 | Rinehart G L Cathoun J H Schabbenberger O | 2002 | Australian Turfgrass Management2002，，4： | 1 |
| 11 | Heat shock proteins are critical for insect winter survival 显示文摘 | Denlinger D L Rinehart J Li A | 2007 | Comparative Biochemistry and Physiology-PartA: Molecular & Integrative Physiology2007，146，： | 1 |
| 12 | Developmental upregulation of inducible hsp70 transcripts, but not the cognate form, during pupal diapause in the flesh fly, Sarcophaga crassipalpis显示文摘 | Rinehart J P Yocum G D Denlinger D L | 2000 | Insect Biochem Mol Biol2000，30，51： | 1 |
| 13 | Antitumor compounds from tunicates 显示文摘 | | 2000 | Med Res Rev2000，20，： | 1 |
| 14 | Estrogen and progesterone receptors in non-small cell lung cancer in 248 consecutive patients who underwent surgical resection 显示文摘 | Di Nunno L Larsson LG Rinehart JJ | 2000 | Arch Pathol Lab Med2000，124，10： | 1 |
| 15 | Urinary 1-hydroxypyene and polycyclic aromatic hydrocarbon exposure among asphalt paving workers 显示文摘 | Mcelean MD Rinehart RD Ngo L | 2004 | Ann Occup Hyg2004，48，6： | 1 |
| 16 | A comparison of coronary angioplasty and coronary artery bypass grafting outcomes in chronic dialysis patients显示文摘 | Rinehart A L Herzog C A Collins A J | 1995 | Am J Kidney Dis1995，25，2： | 1 |
| 17 | Nodularin microcystin and configuration of Adda显示文摘 | Rinehart K L Harada K Namikoshi M | 1998 | A merican Chemical Society1998，110，： | 1 |
| 18 | Antitumor compounds from tunicates显示文摘 | RINEHART K L | 2000 | Med Res Rev2000，20，1： | 1 |
| 19 | A search to identify genetic risk factors for endometriosis显示文摘 | Rotman C Fischel L Cortez G Greiss H Rana N Rinehart J | 2013 | Am J Reprod Immunol2013，69，： | 1 |
| 20 | Estrogen and progesterone receptors in nor small cell lung caner in 248 consecutive patients who underwent surgical resection显示文摘 | Di Nunno L Larsson L G Rinehart J J | 2000 | Arch Pathol Lab Med2000，124，10： | 1 |
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