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| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | Oxidation of AISI 304 and AISI 439 stainless steels显示文摘 | A.M. Huntz A. Reckmann C. Haut C. Sévérac M. Herbst F.C.T. Resende A.C.S. Sabioni | 2006 | Materials Science & Engineering A2006，，1： | 1 |
| 3 | Sulfuric activation of a brazilian manganese ore for heavy metals removal显示文摘 | RESENDE P C BARRADO F S MARTINS A H | 1999 | Hydrometallurgy1999，51，3： | 1 |
| 4 | Atmospheric reaction between the HS radical and chlorine显示文摘 | Resende S M Ornellas F R | 2000 | C P Lett2000，318，： | 1 |
| 5 | Towards automatic conflict de- tection in home and building automation systems 显示文摘 | Carreira P Resendes S Santos A C | 2014 | Pervasive and Mobile Computing2014，12，： | 1 |
| 6 | Widely linear adaptive equalization of digital communication channel 显示文摘 | de Aquino F J A Resende L S da Rocha C A F | 2010 | IEEE Latin America Transactions2010，8，1： | 1 |
| 7 | Parallel GRASP with path-relinking for job shop scheduling 显示文摘 | Aiex R M Binato S Resende M G C | 2003 | Parallel Computing2003，29，： | 1 |
| 8 | Changes in soil C and N stocks and nutrient dynamics 13 years after recovery of degraded land using leguminous nitrogen-fixing trees显示文摘 | Macedo M O Resende A S Garcia P C | 2008 | Forest Ecology and Management2008，255，： | 1 |
| 9 | A fast least squares algorithm for linearly constrained adaptive filtering显示文摘 | Resende L S Romano J M T Bellanger M G | 1996 | IEEE Trans Signal Processing1996，44，3： | 1 |
| 10 | Epitope map- ping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen: correlation with IFN-γ and cytolytic activity by CD8+ T ceils 显示文摘 | Resende D M Caetano B C Dutra M S | 2008 | Vaccine2008，26，35： | 1 |
| 11 | Transient correlation between viremia levels and IL-10 expression in pigs subclinically infected with porcine circovirus type 2(PCV2)显示文摘 | DARWICH L SEGAIéS J RESENDES A | 2008 | Research in Veterinary Science2008，84，2： | 1 |
| 12 | Speeding updynamic shortest-path algorithms显示文摘 | THORUP M BURIOL L S RESENDE M | 2008 | Informs Journal on Computing2008，2，20： | 1 |
| 13 | Sudden bilateral deafness from hyperleukocytosis in chronic myeloid leukemia显示文摘 | Resende L S R Cloradazi A L Rocha C | 2000 | Acta Hematol2000，104，1： | 1 |
| 14 | Lack of an effect of a commercial vaccine adjuvant on the development of postweaning multisystemic wasting syndrome (PMWS) in porcine circovirus type 2 experimentally infected conventional pigs显示文摘 | Resendes A Segalés J Balasch M | 2004 | Veterinary Research2004，35，： | 1 |
| 15 | Apoptosis in lymphoid organs of pigs naturally infected by porcine circovirus type 2 显示文摘 | Resendes A R Majo N Segale s J | 2004 | Journal of General Virology2004，85，： | 1 |
| 16 | Effect of manganese application on yield and seed quality of soybean显示文摘 | Mann E N De Resende P M Mann R S | 2010 | Pesquisa Agro- pecuaria Brasileira2010，37，12： | 1 |
| 17 | Leaf gas ex- change and oxidative stress in sorghum plants supplied with silicon and infected by Colletotrichum sublineolum显示文摘 | Resende R S Rodrigues F A Cavatt P C | 2012 | Phy- topathology2012，102，9： | 1 |
| 18 | Seroiogical cross-reactivity between a porcine Actinobacillus strain and Actinobocillus pleuropneumoniat显示文摘 | Resendal S Mittal K R | 1984 | Can J Microbilo1984，30，： | 1 |
| 19 | 显示文摘 | RESENDE S M ORNELLAS F R | 2000 | Chem Phys Lett2000，318，4： | 1 |
| 20 | Transient correlation between viremia levels and IL-10 expression in pigs subclinically infected with porcine circovirus type 2 (PCV2) 显示文摘 | Darwich L Segale's J Resendes A | 2008 | Research in Veterinary Science2008，84，： | 1 |
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