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您的检索式：作者名="Rebecca Schuster"
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| 1 | Portal vein ligation accelerates tumor growth in ligated,but not contralateral lobes显示文摘AIM: To investigate the mechanisms of liver growth and atrophy after portal vein ligation (PVL) and its effects on tumor growth. METHODS: Mice were subjected to PVL, partial hepatectomy, or sham surgery. The morphological alterations, activation of transcription factors, and expression of cytokines and growth factors involved in liver regeneration were evaluated. In a separate set of experiments, murine colorectal carcinoma cells were injected via the portal vein and the effect of each operation on liver tumor growth was studied. RESULTS: Liver regeneration after PVL and partial hepatectomy were very similar. In ligated lobes, various cytokines, transcription factors and regulatory factors were signifi cantly upregulated compared to nonligated lobes after PVL. Atrophy in ligated lobes was a result of early necrosis followed by later apoptosis. Tumor growth was signifi cantly accelerated in ligated compared to non-ligated lobes.CONCLUSION: Tumor growth was accelerated in ligated liver lobes and appeared to be a result of increased growth factor expression. | Nozomu Sakai Callisia N Clarke Rebecca Schuster John Blanchard Amit D Tevar Michael J Edwards Alex B Lentsch | 2010 | World Journal of Gastroenterology2010，16，30： | 1 |
| 2 | The peptidyl-prolyl isomerase, Pin1, facilitates NF- κ B binding in hepatocytes and protects against hepatic ischemia/reperfusion injury显示文摘 | Satoshi Kuboki Nozomu Sakai Callisia Clarke Rebecca Schuster John Blanchard Michael J. Edwards Alex B. Lentsch | 2009 | Journal of Hepatology2009，，2： | 1 |
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