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| 1 | Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models显示文摘Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(Z.oenoplia) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal models.Methods:Five groups of six rats each were selected for the study.Ethanolic extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated groups.The serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGPT),alkaline phosphatase (SALP),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the liver.Result:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of Z.oenoplia roots.Meanwhile,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose dependency.In addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections.Conclusions:The results of this study slrongly indicate that ethanolic extract of Z.oenoplia has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats. | Ch V Rao AKS Rawat Anil P Singh Arpita Singh Neeraj Verma | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 6 |
| 2 | Faceted and Vertically Aligned GaN Nanorod Arrays Fabricated without Catalysts or Lithography显示文摘 | Deb P Kim H Rawat V | 2005 | Nano Lett2005，5，： | 1 |
| 3 | Action of Asparagus racemosus against streptozotocin-induced oxidative stress显示文摘 | Govindarajan R Vijayakumar M Rao CV Kumar V Rawat AKS Pushpangadan P | 2004 | Nat Prod Sci2004，10，4： | 1 |
| 4 | Faceted and vertically a- ligned GaN nanorod arrays fabricated without catalysts or lithography显示文摘 | Deb P Kim H Rawat V | 2005 | Nano Letters2005，5，9： | 1 |
| 5 | Calcination of Co-based Fischer-Tropsch synthesis catalysts显示文摘 | DE LOOSDRECHT J V BARRADAS S CARICATO E A NGWENYA N G NKWANYANA P S RAWAT M A S SIGWEBELA B H VAN BERGE P J VISAGIE J L | 2003 | Top Catal2003，26，14： | 1 |
| 6 | The vent -likehomeobox gene VENTX promotes human myeloid differentia-tion and is highly expressed in acute myeloid leukemia显示文摘 | RAWAT V P ARSENI N AHMED F | 2010 | Pro-ceedings of the National Academy of Sciences USA2010，107，16： | 1 |
| 7 | The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice 显示文摘 | SCHESSL C RAWAT V P CUSAN M | 2005 | J Clin Invest2005，115，： | 1 |
| 8 | A diploid wheat TILLING resource for wheat functional genomics显示文摘 | Rawat N Sehgal S K Joshi A Rothe N Wilson D L McGraw N Vadlani P V Li W Gill B S | 2012 | BMC Plant Biology2012，12，： | 1 |
| 9 | Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia显示文摘 | Rawat V P Thoene S Naidu V M | 2008 | Blood2008，111，1： | 1 |
| 10 | Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13) (p13;q12) acute myeloid leukemia显示文摘 | Rawat V P Cusan M Deshpande A | 2004 | Proc Natl Acad Sci USA2004，101，3： | 1 |
| 11 | Satellite detection of earthquake thermal infrared precursors in Iran显示文摘 | Saraf A K Rawat V Banerjee P | 2008 | Nat Hazards2008，47，1： | 1 |
| 12 | The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia显示文摘 | Thoene S Rawat V P Heilmeier B | 2009 | Leukemia2009，23，4： | 1 |
| 13 | The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia 显示文摘 | Thoene S Rawat V P Heilmeier B | 2009 | Leukemia2009，23，4： | 1 |
| 14 | Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia 显示文摘 | Rawat V P Thoene S Naidu V M | 2008 | Blood2008，111，1： | 1 |
| 15 | A diploid wheat TILLING resource for wheat functional genomics显示文摘 | Rawat N Sehgal S K Joshi A Rothe N Wilson D L Mcgraw N Vadlani P V Li W Gill B S | 2012 | BMC Plant Biology2012，12，： | 1 |
| 16 | Intrusion Detection Using Text Processing Techniques with a Binary-Weighted Cosine Metric 显示文摘 | Rawat S Gulati V P Arun K P | 2006 | Journal of Information Assurance and Security2006，1，1： | 1 |
| 17 | The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice显示文摘 | Schessl C Rawat V P Cusan M | 2005 | Clin Invest2005，115，8： | 1 |
| 18 | Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication显示文摘 | Ahluwalia JK Khan SZ Soni K Rawat P Gupta A Hariharan M Scaria V Lalwani M Pillai B Mitra D Brahmachari SK | 2008 | Retrovirology2008，5，： | 1 |
| 19 | Intrusion detection using text processing techniques with a binary-weighted cosine metric显示文摘 | RAWAT S GULATI V P PUJARI A K | 2006 | Journal of Information Assurance and Security2006，1，1： | 1 |
| 20 | The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice显示文摘 | SCHESSL C RAWAT V P CUSAN M | 2005 | J Clin Invest2005，115，： | 1 |
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