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| 1 | 【特刊综述】利用雄激素受体敲除(ARKO)小鼠模型认识人类雄激素缺乏显示文摘雄激素的作用机理很复杂。最近,使用转基因修饰小鼠模型进行的雄激素受体研究使我们对雄激素作用机理有了更进一步的理解。Cre-loxP系统能够完成组织和/或细胞特异性的敲除。通过使用Cre—loxP系统已经获得了大量整体性或组织特异性雄激素受体(ARK0)敲除模型。这些ARKO模型的多个雄激素作用位点,包括心血管系统、免疫和造血系统、骨骼、肌肉、脂肪组织、前列腺和脑,均已被检测。本篇综述着重阐述了通过针对这些雄激素作用位点的ARKO小鼠模型而取得的人类雄激素缺乏的研究成果,并且指出充分理解Cre-loxPdx鼠模型的优缺点才能正确认识其表型。 | Kesha Rana Rachel A Davey Jeffrey D Zajac | 2014 | Asian Journal of Andrology2014，16，2： | 13 |
| 2 | myocardial 以后梗塞巨人让室的 pseudoaneurysm 与严重的心失败介绍显示文摘 Left ventricle(LV) pseudoaneurysm is a late mechanical complication of myocardial infarction.A giant LV pseudoaneurysm is a rare presentation.We report a case of giant LV pseudoaneurysm in a post-MI patient who presented with gross congestive heart failure.The patient had a successful surgical repair of the aneurysm and had a favorable 3-mo outcome.The imaging modality and surgical treatment of the pseudoaneurysm are discussed. | Rajesh Vijayvergiya Alok Kumar Sandeep S Rana Harkant Singh Goverdhan D Puri Manphool Singhal | 2012 | World Journal of Cardiology2012，4，11： | 3 |
| 3 | 雄激素受体的目标基因在骨骼肌的表达显示文摘本文通过研究体外和体内模型中潜在的雄激素受体调节基因来确定骨骼肌中雄激素的合成代谢作用机制。睾酮治疗组的去势雄性小鼠与对照组去势雄性小鼠比较,其骨骼肌中肌源性调节因子肌细胞生成素的表达显著下降,而缺乏DNA结合活性的雄性雄激素受体敲除小鼠(AR^△ZF2)与野生型小鼠比较,其骨骼肌中肌源性调节因子肌细胞生成素的表达显著升高,证明了肌细胞生成素是通过雄激素/雄激素受体通路被抑制。通过12小时的骨骼肌细胞(SkMC)的成肌细胞联合双氢睾酮治疗,睾酮治疗组的去势雄性小鼠肌肉中的泛素连接酶Fbxo32被抑制,而肌肉中c—Myc表达较对照组去势雄性小鼠降低,在△R^△ZF2组小鼠肌肉中c-Myc表达升高。调节成肌细胞由增殖向分化转变的一组基因如Tceal7,p57^Kip2,Igf2和钙调磷酸酶Aa的表达在AR^△ZF2组小鼠肌肉中升高,除p57^Kip2外的上述所有基因在睾酮治疗组去势雄性小鼠肌肉中的表达均较对照组降低。因此得出结论,雄激素通过雄激素受体在雄性小鼠体内发挥作用,它在肌肉生长和发展过程中可维持成肌细胞处于增殖状态并推迟成肌细胞向分化状态转变,另外还可抑制泛素连接酶介导的导致肌肉萎缩的通路来保持小鼠肌肉质量,从而一定程度上促进肌肉不断生长达到顶峰。 | Kesha Rana Nicole KL Lee Jeffrey D Zajac Helen E MacLean | 2014 | Asian Journal of Andrology2014，16，5： | 3 |
| 4 | The use of inter-specific hybrids in aquaculture and fisheries显示文摘 | Bartley D M Rana K Immink A J | 2000 | Rev Fish Biol Fisheries2000，10，3： | 1 |
| 5 | The effect of sodium dodecyl sulphate on Furosemide - A cardiovascular drug in water-methanol at different temperature显示文摘 | KAUSHA D RANA D S CHAUHAN M S | 2013 | Journal of Molecular Liquids2013，188，： | 1 |
| 6 | Surface modifications for anti-fouling membranes显示文摘 | Rana D Matsuura T | 2010 | Chem Rev2010，110，： | 1 |
| 7 | The use of interspecific hybrids in aquaculture and fisheries显示文摘 | Bartly D M Rana K Immink J | 2001 | Reviews in Fish Biology and Fisheries2001，10，： | 1 |
| 8 | Hybrid connection algorithm:A strategy for efficient restoration in WDM optical networks显示文摘 | Yadav D Rana S Prakash S | 2010 | Optical Fiber Technology2010，16，2： | 1 |
| 9 | Surface modifications for anti- fouling membranes显示文摘 | Rana D Matsuura T | 2010 | Chem Rev2010，110，4： | 1 |
| 10 | Degradation of trace concentrations of alachlor by medium frequency ultrasound显示文摘 | Rana K Sifa D | 2015 | Chemical Engineering and Processing:Process Intensification2015，89，： | 1 |
| 11 | Detection of canine echinococcosis by coproantigen ELISA显示文摘Objective:To study the canine echinococcosis by coproantigen ELISA method.Methods:During the present investigation experimental infection was established using evaginated worms of Echinococcus granulosus(E.granulosus).To check cross reactivity two pups were infected with Taenia hydatigena(T.hydatigena).In order to detect the presence of antigen,hyperimmune sera were raised against excretory-secretory products of adult worms E.chinococcus granulosus. Faecal sample collected either from experimentally infected pups or from other sources were heated at 70℃to detect heat stable soluble antigen.Results:Pups harbouring less than 104 worms showed negative results.Samples collected from 14 days onwards from experimentally infected animals harbouring more than 104 worms showed positive value.The maximum positive samples were detected in samples collected from in and around slaughter house and the least number of samples were detected positive maintained by dog squad.Conclusions:The affinity purified IgG exhibited promising results for detection of canine echinococcosis by indirect ELISA. | De S Pan D Bera AK Sreevatsava V Das SK Das S Rana T Bandyopadhyay S Bhattacharya D | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 1 |
| 12 | The mechanical properties of vinylester resin matrix composites reinforced with alkali-treated jute fibres 显示文摘 | D Ray B K Sarkar A K Rana | 2001 | Composites2001，32，： | 1 |
| 13 | Genetic structure of the Pleurotus eryngii species-complex 显示文摘 | de Gioia T Sisto D Rana G L | 2005 | Mycol Res2005，109，： | 1 |
| 14 | Physico-chemical characterization and catalysis on mesoporous Al - HMS supported molybdenum hydrotreating catalysts 显示文摘 | Chiranjeevi T Kumar D Rana M S | 2002 | J Mol Catal A: Chem2002，181，： | 1 |
| 15 | Preparation of thin-film-composite polyamide membranes for desalination using novel hydrophilic surface modifying macromolecules 显示文摘 | Belal J Abu Tarboush D Rana T Matsuura | 2008 | Joumal of Membrane Science2008，325，： | 1 |
| 16 | Structural dependence of terahertz radiation from multiferroic BiFeO3 thin films显示文摘 | Rana D S Takahashi K Mavan K R | 2008 | PhysRev B2008，77，02： | 1 |
| 17 | Sperm-associated antigen 9, a novel cancer testis antigen, is a potential tar- get for immunotherapy in epithelial ovarian cancer 显示文摘 | Garg M Chaurasiya D Rana R | 2007 | Clin Cancer Res2007，13，5： | 1 |
| 18 | Influence of Electro- spun Fiber Size On the Separation Efficiency of Thin Film Nanofiltration Composite Membrane显示文摘 | Kaur S Sundarrajan S Rana D | 2012 | Journal of Membrane Science2012，，392： | 1 |
| 19 | G-QoSM: Grid service discovery using QoS properties显示文摘 | AL-ALI R RANA O WALKER D | 2003 | Computing and Informaties Journal Special Issue on Grid Computing2003，，： | 1 |
| 20 | A teratocyte gene from a parasitic wasp that is inhibits host protein synthesis显示文摘 | Dahlman D L Rana R L Schepers E J | 2003 | Insect Molecular Biology2003，12，： | 1 |
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