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| 1 | Diagnosis of obscure gastrointestinal bleeding by intraoperative enteroscopy in 81 consecutive patients显示文摘瞄准:为了由与流血调查一系列选择病人分析 intra 起作用的肠寄生物(IOE ) 的结果和复杂并发症,怀疑了从小肠发源。方法:81 个病人(吝啬的年龄:65 年) 包括 40,男性(49.4%) 和有阴暗胃肠的流血的 41 女性(50.6%) 经历了在 1990 和 2004 之间的 IOE。病人从一个数据库被识别,数据回顾地从病人的图表被选择。所有病人在 IOE 前经历了至少一非诊断的 esophagogastroduodenoscopy,结肠镜检查,标准肠寄生物和否定腹的超声扫描。结果:在病人的中部的最小的血红素水平是 59 + 15 g/L 并且 72.8% 病人以前要求了包装红血球的输送。流血来源在 68 被检测(84%) 病人在 IOE 期间。Angiodysplasiae 在 44 个病人(54.3%) 被发现, 9 个病人(11.1%) 被溃疡在小肠影响。在小肠的一个肿瘤在另外一个被检测 6 个病人。治疗在大多数病人由 argon-plasma-coagulation,外科的缝术或有限切除术组成了。结论:Intra 起作用的肠寄生物仍然为怀疑的小肠流血的诊断被使用。最近的开发象无线的囊内视镜检查法和两倍汽球肠寄生物那样,以后可以导致 IOE 的代替。 | Ralf Jakobs Dirk Hartmann Claus Benz Dieter Schilling Uwe Weickert Axel Eickhoff Klaus Schoenleben Juergen F Riemann | 2006 | World Journal of Gastroenterology2006，12，2： | 5 |
| 2 | A prospective two-center study comparing wireless capsule endoscopy with intraoperative enteroscopy in patients with obscure GI bleeding显示文摘 | Dirk Hartmann Harald Schmidt Georg Bolz Dieter Schilling Frank Kinzel Axel Eickhoff Winfried Huschner Kathleen M?ller Ralf Jakobs Peter Reitzig Uwe Weickert Klaus Gellert Harald Schultz Klaus Guenther Hartmut Hollerbuhl Klaus Schoenleben Hans-Joachim Schu | 2005 | Gastrointestinal Endoscopy2005，，7： | 2 |
| 3 | Self-expanding metal stents for the palliation of malignant gastric outlet obstruction in patients with peritoneal carcinomatosis显示文摘AIM To evaluate the efficacy of self-expanding metal stents(SEMS) for the palliation of malignant gastric outlet obstruction in patients with and without peritoneal carcinomatosis(PC).METHODS We performed a retrospective analysis of 62 patients who underwent SEMS placement for treatment of malignant gastroduodenal obstruction at our hospital over a six-year period. Stents were deployed through the scope under combined fluoroscopic and endoscopic guidance. Technical success was defined as successful stent placement and expansion. Clinical success was defined as an improvement in the obstructive symptoms and discharge from hospital without additional parenteral nutrition. According to carcinomatosis status, patients were assigned into groups with or without evidence of peritoneal disease.RESULTS In most cases, obstruction was caused by pancreatic(47%) or gastric cancer(23%). Technical success was achieved in 96.8%(60/62), clinical success in 79%(49/62) of all patients. Signs of carcinomatosis were identified in 27 patients(43.5%). The diagnosis was confirmed by pathology or previous operation in 7 patients(11.2%) and suspected by CT, MRI or ultrasound in 20 patients(32.2%). Presence of carcinomatosis was associated with a significantly lower clinical success rate compared to patients with no evidence of peritoneal disease(66.7% vs 88.6%, P = 0.036). There was no significant difference in overall survival between patients with or without PC(median 48 d vs 70 d, P = 0.21), but patients showed significantly longer survival after clinical success of SEMS placement compared to those experiencing clinical failure(median 14.5 d vs 75 d, P = 0.0003).CONCLUSION Given the limited therapeutic options and a clinical success rate of at least 66.7%, we believe that SEMS are a reasonable treatment option in patients with malignant gastric outlet obstruction with peritoneal carcinomatosis. | Christoph Rademacher Matthias Bechtler Steffen Schneider Bettina Hartmann Johannes Striegel Ralf Jakobs | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 4 | PillCamColon2 after incomplete colonoscopy-A prospective multicenter study显示文摘AIM To evaluate the ability of PillCamColon2 to visualize colonic segments missed by incomplete optical colonoscopy(OC) and to assess the diagnostic yield.METHODS This prospective multicentre study included 81 patients from nine centres who underwent second-generation colon capsule endoscopy(CCE) following incomplete OC performed by an experienced gastroenterologist(> 1000 colonoscopies). Patients with stenosis were excluded. According to patient preferences, CCE was performed the following day(protocol A) after staying on clear liquids and 0.75 L Moviprep in the morning or within 30 d after new split-dose Moviprep(protocol B). Boosts consisted of 0.75 L and 0.25 L Moviprep, and phospho-soda was given as a rescue if the capsule was not excreted after seven hours.RESULTS Seventy-four patients were analysed(51% of them in group A; 49% in group B). Bowel cleansing was adequate in 67% of cases, and CCE could visualize colonic segments missed by incomplete colonoscopy in 90% of patients under protocol A and 97% of patients under protocol B(P = 0.35, n.s.). Significant polyps including adenocarcinoma were detected in 24% of cases. Detection rates for all polyps and significant polyps per patient were similar in both protocols. Polyps were found predominantly in the right colon(86%) in segments that were not reached by OC. Extracolonic findings-such as reflux esophagitis, suspected Barrett esophagus, upper GI-bleeding, gastric polyps, gastric erosions and angiectasia-were detected in eight patients. Pill Cam Colon2 capsule was retained in the ileum of one patient(1.4%) without symptoms and removed during an uneventful resection for unknown Crohn's disease that was diagnosed as the cause of anemia, which was the indication for colonoscopy. CCE was well tolerated. One patient suffered from selflimiting vomiting after consuming the phospho-soda.CONCLUSION Second-generation CCE using a low-volume preparation is useful after incomplete OC, and it allows for the detection of additional relevant findings, but cleansing efficiency could be improved. | Peter Baltes Marc Bota Jorg Albert Michael Philipper Hans-Georg Horster Friedrich Hagenmüller Ingo Steinbrück Ralf Jakobs Matthias Bechtler Dirk Hartmann Horst Neuhaus Jean-Pierre Charton Rupert Mayershofer Horst Hohn Thomas Rosch Stefan Groth Tanja Nowak Peter Wohlmuth Martin Keuchel | 2018 | World Journal of Gastroenterology2018，24，31： | 1 |
| 5 | Diagnosis of Liver Cirrhosis: A Comparison of Modified Ultrasound and Laparoscopy in 100 Consecutive Patients显示文摘 | Uwe Weickert Andrea Buttmann Ralf Jakobs Dieter Schilling Axel Eickhoff Jürgen Ferdinand Riemann | 2005 | Journal of Clinical Gastroenterology2005，，6： | 1 |
| 6 | Accuracy of high-resolution chromoendoscopy in prediction of histologic findings in diminutive lesions of the rectosigmoid显示文摘 | Dariusz Apel Ralf Jakobs Dieter Schilling Uwe Weickert Joachim Teichmann Manfred H. Bohrer Jürgen F. Riemann | 2006 | Gastrointestinal Endoscopy2006，，6： | 1 |
| 7 | Case Report: Primary Clear Cell Carcinoma of Noncirrhotic Liver (Immunohistochemical Discrimination of Hepatocellular and Cholangiocellular Origin)显示文摘 | Henning E. Adamek Andreas Spiethoff Volker Kaufmann Ralf Jakobs Juergen F. Riemann | 1998 | Digestive Diseases and Sciences1998，，1： | 1 |
| 8 | Low seroprevalence of Helicobacter pylori infection in patients with stress ulcer bleeding显示文摘 | Dieter Schilling Günter Haisch Norbert Sloot Ralf Jakobs Werner Saggau Jürgen F. Riemann | 2000 | Intensive Care Medicine2000，，12： | 1 |
| 9 | Pilot randomized trial of selective internal radiation therapy vs. chemoembolization in unresectable hepatocellular carcinoma显示文摘 | Frank T. Kolligs Jose I. Bilbao Tobias Jakobs Mercedes I?arrairaegui Jutta M. Nagel Macarena Rodriguez Alexander Haug Delia D’Avola Mark op den Winkel Antonio Martinez‐Cuesta Christoph Trumm Alberto Benito Klaus Tatsch Christoph J. Zech Ralf‐Thorsten Hoff | 2015 | Liver Int2015，，6： | 1 |
| 10 | Immunogenic cell death biomarkers HMGB1, RAGE, and DNAse indicate response to radioembolization therapy and prognosis in colorectal cancer patients显示文摘 | Yvonne Nadine Fahmueller Dorothea Nagel Ralf‐Thorsten Hoffmann Klaus Tatsch Tobias Jakobs Petra Stieber Stefan Holdenrieder | 2013 | Int. J. Cancer2013，，： | 1 |
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