| 1 | In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation显示文摘Objective:To explore potential natural products against severe acute respiratory syndrome coronavirus(SARS-CoV-2)via the study of structural and non-structural proteins of human coronaviruses.Methods:In this study,we performed an in-silico survey of 25 potential natural compounds acting against SARS-CoV-2.Molecular docking studies were carried out using compounds against 3-chymotrypsin-like protease(3 CL^(PHO)),papain-like protease(PL^(PRO)),RNA-dependent RNA polymerase(RdRp),non-structural protein(nsp),human angiotensin converting enzyme 2 receptor(hACE2 R),sapike glycoprotein(S protein),abelson murine leukemia viral oncogene homolog 1(ABL1),calcineurin-nuclear factor of activated T-cells(NFAT)and transmembrane protease serine 2.Results:Among the screened compounds,amentoflavone showed the best binding affinity with the 3 CL^(PRO),RdRp,nsp13,nsp15,hACE2 R,ABL1 and calcineurin-NFAT;berbamine with hACE2 R and ABL1;cepharanthine with nsp10,nsp14,nsp16,S protein and ABL1;glucogallin with nsp15;and papyriflavonol A with PL^(PRO)protein.Other good interacting compounds were juglanin,betulinic acid,betulonic acid,broussooflavan A,tomentin A,B and E,7-methoxycryptopleurine,aloe emodin,quercetin,tanshinone I,tylophorine and furruginol,which also showed excellent binding affinity towards a number of target proteins.Most of these compounds showed better binding affinities towards the target proteins than the standard drugs used in this study.Conclusion:Natural products or their derivatives may be one of the potential targets to fight against SARS-CoV-2. | Rajib Hossain Chandan Sarkar Shardar Mohammad Hafiz Hassan Rasel Ahmed Khan Mohammad Arman Pranta Ray Muhammad Torequl Islam Sevgi Durna Dastan Javad Sharifi-Rad Zainab M. Almarhoon Miquel Martorell William N. Setzer Daniela Calina | 2022 | Chinese Journal of Integrative Medicine2022，28，3： | 2 |
| 2 | A multi-purpose National Forest Inventory in Bangladesh:design,operationalisation and key results显示文摘Background:National forest inventory and forest monitoring systems are more important than ever considering continued global degradation of trees and forests.These systems are especially important in a country like Bangladesh,which is characterised by a large population density,climate change vulnerability and dependence on natural resources.With the aim of supporting the Government’s actions towards sustainable forest management through reliable information,the Bangladesh Forest Inventory(BFI)was designed and implemented through three components:biophysical inventory,socio-economic survey and remote sensing-based land cover mapping.This article documents the approach undertaken by the Forest Department under the Ministry of Environment,Forests and Climate Change to establish the BFI as a multipurpose,efficient,accurate and replicable national forest assessment.The design,operationalization and some key results of the process are presented.Methods:The BFI takes advantage of the latest and most well-accepted technological and methodological approaches.Importantly,it was designed through a collaborative process which drew from the experience and knowledge of multiple national and international entities.Overall,1781 field plots were visited,6400 households were surveyed,and a national land cover map for the year 2015 was produced.Innovative technological enhancements include a semi-automated segmentation approach for developing the wall-to-wall land cover map,an object-based national land characterisation system,consistent estimates between sample-based and mapped land cover areas,use of mobile apps for tree species identification and data collection,and use of differential global positioning system for referencing plot centres.Results:Seven criteria,and multiple associated indicators,were developed for monitoring progress towards sustainable forest management goals,informing management decisions,and national and international reporting needs.A wide range of biophysical and socioeconomic data were collected,and in some cases integrated,for estimating the indicators.Conclusions:The BFI is a new information source tool for helping guide Bangladesh towards a sustainable future.Reliable information on the status of tree and forest resources,as well as land use,empowers evidence-based decision making across multiple stakeholders and at different levels for protecting natural resources.The integrated socioeconomic data collected provides information about the interactions between people and their tree and forest resources,and the valuation of ecosystem services.The BFI is designed to be a permanent assessment of these resources,and future data collection will enable monitoring of trends against the current baseline.However,additional institutional support as well as continuation of collaboration among national partners is crucial for sustaining the BFI process in future. | Matieu Henry Zaheer Iqbal Kristofer Johnson Mariam Akhter Liam Costello Charles Scott Rashed Jalal Md.Akhter Hossain Nikhil Chakma Olaf Kuegler Hossain Mahmood Rajib Mahamud Mohammad Raqibul Hasan Siddique Khaled Misbahuzzaman Mohammad Main Uddin Mohammed Al Amin Farid Uddin Ahmed Gael Sola Md.Baktiar Siddiqui Luca Birigazzi Mahmudur Rahman Ilias Animon Saimunnahar Ritu Laskar Muqsudur Rahman Aminul Islam Heather Hayden Frida Sidik Mondal Falgoonee Kumar Rakibul Hassan Mukul Hossain Nishad Ariful Hoque Belal Asif Reza Anik Abdul Khaleque Md.Shaheduzzaman Syed Shahadat Hossain Tariq Aziz Md.Tauhidor Rahaman Ruhul Mohaiman Patrick Meyer Purnata Chakma A.Z.M.Manzoor Rashid Sourav Das Shrabanti Hira Mohammed Jashimuddin Mohammad Mahfuzur Rahman Karl Wurster Sarder Nasir Uddin Abul Kalam Azad S.M.Zahirul Islam Laurent Saint-André | 2021 | Forest Ecosystems2021，8，1： | 0 |
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