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| 1 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 2 | Pre-intervention cerebral blood volume predicts outcomes in patients undergoing endovascular therapy for acute ischemic stroke 显示文摘 | Rai AT Raghuram K Carpenter JS et ol | 2013 | J Neurointe Surg2013，，1： | 1 |
| 3 | Comparison of devices used for stent-assisted coiling of intracranial aneurysms 显示文摘 | Izar B Rai A Raghuram K | 2011 | Plos One2011，6，24： | 1 |
| 4 | Study on microstruc- tures of electron beam and gas tungsten are Ti-6AAI-4V weld met- als显示文摘 | Radhakr I C Raghuram 1 R Prasad R K | 1997 | Practical Metallography1997，34，4： | 1 |
| 5 | A mitogen-activated protein kinase cascade module,MKK3-MPK6 and MYC2,is involved in blue light-mediated seedling development in Arabidopsis显示文摘 | SETHI V RAGHURAM B SINHA A K | 2014 | Plant Cell2014，19，3： | 1 |
| 6 | Analysis of surface texture generated by a flexible magnetic abrasive brush 显示文摘 | Singh Dhirendra K Jain V K Raghuram V Komanduri R | 2005 | Wear2005，259，： | 1 |
| 7 | Benign triton tumor of the trigeminal nerve显示文摘 | Castro DE Raghuram K Phillips CD | 2005 | AJNr2005，26，： | 1 |
| 8 | Identification of heme as the ligand for the orphan nuclear receptors REV- ERBalpha and REV-ERBbeta 显示文摘 | Raghuram S Stayrook K R Huang P | 2007 | Nat Stract Mol Biol2007，14，12： | 1 |
| 9 | Investigations on the nature of the phytoehrome-induced transmitter for the regulation of nitrate rednetase in etiolated leaves of maize 显示文摘 | Sharma A K Raghuram N Chandok M R | 1994 | J Exp B ot1994，45，： | 1 |
| 10 | Comparison of devices used for stent-assisted coiling of intracranial aneurysms 显示文摘 | IZAR B RAI A RAGHURAM K | 2011 | PLoS One2011，6，24： | 1 |
| 11 | Analysis of surface texture generated by a flexible magnetic abrasive brush 显示文摘 | Singh Dhirendra K Jain V K Raghuram V | 2005 | Wear2005，259，712： | 1 |
| 12 | Effect of cryo-rolling and annealing on microstructure and properties of commercially pure aluminium显示文摘 | RANGARAJU N RAGHURAM T KRlSHNA B V RAO K P VENUGOPAL P | 2005 | Materials Science and Engineering A2005，398，： | 1 |
| 13 | Effect of 6 months intense Yoga practice on lipid profile, thyroxine medication and serum TSH level in women suffering from hypothyroidism: a pilot study 显示文摘 | Nilakanthan S Metri K Raghuram N | 2016 | J Complement Integr Med2016，13，2： | 1 |
| 14 | Mitogen-activated protein kinase signaling in plants under abiotic stress显示文摘 | Sinha A K Jaggi M Raghuram B Tuteja N | 2011 | Plant Signal& Behavior2011，6，2： | 1 |
| 15 | Parametric study of magnetic abrasive finishing process显示文摘 | Dhirendra K Singh V K Jain V Raghuram | 2004 | Journal of Materials Processing Technology2004，，149： | 1 |
| 16 | Parametric study of magnetic abrasive finishing process显示文摘 | Dhirendra K Singh V K Jain and Raghuram V | 2004 | Journal of Materials Process Technology2004，，149： | 1 |
| 17 | Preoperative embolisation in benign bone tumour excision显示文摘 | Lee V N Nithyananth M Cherian V M Amritanand R Venkatesh K Sundararaj G D Raghuram L N | 2008 | Journal of Orthopaedic Surgery2008，，： | 1 |
| 18 | Analysis of surface texture generated by a flexible magnetic abrasive brush显示文摘 | Singh D K Jain V K Raghuram V | | 0，，： | 1 |
| 19 | Pancreatic cell immobilization in alginate beads pro-duced by emulsion and internal gelation显示文摘 | HOESLI C A RAGHURAM K KING R L J | 2011 | Biotech-nology and Bioengineering2011，108，2： | 1 |
| 20 | Analysis of Surface texture generated by a flexible magnetic abrasive brush 显示文摘 | Singh D K Jain V K Raghuram V | 2005 | Wear2005，，259： | 1 |
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