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| 1 | Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography显示文摘AIM:To investigate foveal avascular zone(FAZ) and parafoveal vessel densities(PRVD) by means of optical coherence tomography angiography(OCTA) in diabetic patients with or without diabetic retinopathy(DR) and to assess the reproducibility of FAZ and PRVD measurements.METHODS:Sixty diabetic patients(60 eyes) with different stage of DR(graded according to the International Clinical Severity Scale for DR) and 20 healthy subjects underwent FAZ area and PRVD measurements using OCTA by two experienced examiners.FAZ area in all patients was also assessed using fluorescein angiography(FA).RESULTS:In subject with proliferative DR and with moderate-severe non proliferative DR,FAZ area was significantly increased compared to healthy controls(P=0.025 and P=0.050 respectively measured with OCTA and P=0.025 and P=0.048 respectively measured with FA).OCTA showed significantly less inter-observer variability compared to FA.Concordance correlation coefficient(CCC) for FAZ area measurements was 0.829(95%CI:0.736-0.891) P<0.001 with FA and 1.000(95%CI:0.999-1.000) P<0.001 with OCTA.CCC was 0.834(95%CI:0.746-0.893) P<0.001 and 0.890(95%CI:0.828-0.930) P<0.001 for parafoveal superficial and deep vessel density measurements,respectively.CONCLUSION:OCTA shows progressive increase of FAZ area and reduction of PRVD in both superficial and deep plexus at increasing DR severity.FAZ area and PRVD measurements using OCTA are highly reproducible. | Rodolfo Mastropasqua Lisa Toto Alessandra Mastropasqua Raffaella Aloia Chiara De Nicola Peter A Mattei Guido Di Marzio Marta Di Nicola Luca Di Antonio | 2017 | International Journal of Ophthalmology(English edition)2017，10，10： | 26 |
| 2 | phytoestrogens/insoluble fibers and colonic estrogen receptor β: randomized, double-blind, placebo-controlled study显示文摘AIM:To assess the safety and effect of the supplementation of a patented blend of dietary phytoestrogens and insoluble fibers on estrogen receptor (ER)-β and biological parameters in sporadic colonic adenomas. METHODS:A randomized, double-blind placebo-controlled trial was performed. Patients scheduled to undergo surveillance colonoscopy for previous sporadic colonic adenomas were identified, and 60 eligible patients were randomized to placebo or active dietary intervention (ADI) twice a day, for 60 d before surveillance colonoscopy. ADI was a mixture of 175 mg milk thistle extract, 20 mg secoisolariciresinol and 750 mg oat fiber extract. ER-β and ER-α expression, apoptosis and proliferation (Ki-67 LI) were assessed in colon samples. RESULTS:No adverse event related to ADI was recorded. ADI administration showed a significant increases in ER-β protein (0.822 ± 0.08 vs 0.768 ± 0.10, P = 0.04) and a general trend to an increase in ER-β LI (39.222 ± 2.69vs 37.708 ± 5.31,P = 0.06), ER-β/ER-α LI ratio (6.564 ± 10.04 vs 2.437 ± 1.53, P = 0.06), terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (35.592 ± 14.97 vs 31.541 ± 11.54, P = 0.07) and Ki-67 (53.923 ± 20.91 vs 44.833 ± 10.38, P = 0.07) approximating statistical significance. A significant increase of ER-β protein (0.805 ± 0.13 vs 0.773 ± 0.13,P = 0.04), mRNA (2.278 ± 1.19vs 1.105 ± 1.07, P < 0.02) and LI (47.533 ± 15.47 vs 34.875 ± 16.67,P < 0.05) and a decrease of ER-α protein (0.423 ± 0.06vs 0.532 ± 0.11,P < 0.02) as well as a trend to increase of ER-β/ER-α protein in ADI vs placebo group were observed in patients without polyps (1.734 ± 0.20 vs 1.571 ± 0.42, P = 0.07). CONCLUSION:The role of ER-β on the control of apoptosis, and its amenability to dietary intervention, are supported in our study. | Mariabeatrice Principi Alfredo Di Leo Maria Pricci Maria Principia Scavo Raffaella Guido Sabina Tanzi Domenico Piscitelli Antonio Pisani Enzo Ierardi Maria Cristina Comelli Michele Barone | 2013 | World Journal of Gastroenterology2013，19，27： | 3 |
| 3 | A 28-Year Study of the Course of Hepatitis Δ Infection: A Risk Factor for Cirrhosis and Hepatocellular Carcinoma显示文摘 | Raffaella Romeo Ersilio Del Ninno Mariagrazia Rumi Antonio Russo Angelo Sangiovanni Roberto de Franchis Guido Ronchi Massimo Colombo | 2009 | Gastroenterology2009，，5： | 2 |
| 4 | Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance显示文摘 | Angelo Sangiovanni Ersilio Del Ninno Pierangelo Fasani Cristina De Fazio Guido Ronchi Raffaella Romeo Alberto Morabito Roberto de Franchis Massimo Colombo | 2004 | Gastroenterology2004，，4： | 2 |
| 5 | Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα显示文摘 | Giulia Ranaldi Simonetta Ferruzza Raffaella Canali Guido Leoni Peter D. Zalewski Yula Sambuy Giuditta Perozzi Chiara Murgia | 2013 | The Journal of Nutritional Biochemistry2013，，6： | 1 |
| 6 | Estrogens, phytoestrogens and colorectal neoproliferative lesions显示文摘 | Michele Barone Sabina Tanzi Katia Lofano Maria Principia Scavo Raffaella Guido Lucia Demarinis Maria Beatrice Principi Antongiulio Bucci Alfredo Di Leo | 2008 | Genes & Nutrition2008，，1： | 1 |
| 7 | ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis显示文摘 | Michele Barone Maria Principia Scavo Samanta Papagni Domenico Piscitelli Raffaella Guido Maria Di Lena Maria Cristina Comelli Alfredo Di Leo | 2010 | Scandinavian Journal of Gastroenterology2010，，11： | 1 |
| 8 | Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance显示文摘 | Angelo Sangiovanni Ersilio Del Ninno Pierangelo Fasani Cristina De Fazio Guido Ronchi Raffaella Romeo Alberto Morabito Roberto de Franchis Massimo Colombo | 2004 | Gastroenterology2004，，4： | 1 |
| 9 | Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance显示文摘 | Angelo Sangiovanni Ersilio Del Ninno Pierangelo Fasani Cristina De Fazio Guido Ronchi Raffaella Romeo Alberto Morabito Roberto de Franchis Massimo Colombo | 2004 | Gastroenterology2004，，4： | 1 |
| 10 | Estrogens, phytoestrogens and colorectal neoproliferative lesions显示文摘 | Michele Barone Sabina Tanzi Katia Lofano Maria Principia Scavo Raffaella Guido Lucia Demarinis Maria Beatrice Principi Antongiulio Bucci Alfredo Di Leo | 2008 | Genes & Nutrition2008，，1： | 1 |
| 11 | Prognostic value of serum uric acid: new-onset in and out-of-office hypertension and long-term mortality显示文摘 | Michele Bombelli Irene Ronchi Marco Volpe Rita Facchetti Stefano Carugo Raffaella Dell’Oro Cesare Cuspidi Guido Grassi Giuseppe Mancia | 2014 | Journal of Hypertension2014，，6： | 1 |
| 12 | Essential hypertension and the sympathetic nervous system显示文摘 | Guido Grassi Fosca Quarti-Trevano Raffaella Dell’Oro Giuseppe Mancia | 2008 | Neurological Sciences2008，，1： | 1 |
| 13 | Early effects of total paracentesis and albumin infusion on muscle sympathetic nerve activity in cirrhotic patients with tense ascites显示文摘 | Massimo Pozzi Guido Grassi Valeria Pecci Carlo Turri Giuseppe Boari Giovanni Battista Bolla Raffaella Dell’Oro Sara Massironi Luigi Roffi Giuseppe Mancia | 1999 | Journal of Hepatology1999，，1： | 1 |
| 14 | A 28-Year Study of the Course of Hepatitis Δ Infection: A Risk Factor for Cirrhosis and Hepatocellular Carcinoma显示文摘 | Raffaella Romeo Ersilio Del Ninno Mariagrazia Rumi Antonio Russo Angelo Sangiovanni Roberto de Franchis Guido Ronchi Massimo Colombo | 2009 | Gastroenterology2009，，5： | 1 |
| 15 | Fibrosis in chronic hepatitis C acquired in infancy: is it only a matter of time?显示文摘 | Maria Guido Flavia Bortolotti Gioacchino Leandro Paloma Jara Loreto Hierro Javier Larrauri Cristiana Barbera Raffaella Giacchino Lucia Zancan Fiorella Balli Carlo Crivellaro Emilio Cristina Angela Pucci Massimo Rugge | 2003 | The American Journal of Gastroenterology2003，，3： | 1 |
| 16 | Prognostic value of serum uric acid: new-onset in and out-of-office hypertension and long-term mortality显示文摘 | Michele Bombelli Irene Ronchi Marco Volpe Rita Facchetti Stefano Carugo Raffaella Dell’Oro Cesare Cuspidi Guido Grassi Giuseppe Mancia | 2014 | Journal of Hypertension2014，，： | 1 |
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