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| 1 | Induced pluripotent stem cells for modeling neurological disorders显示文摘Several diseases have been successfully modeled since the development of induced pluripotent stem cell(i PSC) technology in 2006. Since then, methods for increased reprogramming efficiency and cell culture maintenance have been optimized and many protocols for differentiating stem cell lines have been successfully developed, allowing the generation of several cellular subtypes in vitro. Gene editing technologies have also greatly advanced lately, enhancing disease-specific phenotypes by creating isogenic cell lines, allowing mutations to be corrected in affected samples or inserted in control lines. Neurological disorders have benefited the most from i PSC-disease modeling for its capability for generating disease-relevant cell types in vitro from the central nervous system, such as neurons and glial cells, otherwise only available from post-mortem samples. Patient-specific i PSC-derived neural cells can recapitulate the phenotypes of these diseases and therefore, considerably enrich our understanding of pathogenesis, disease mechanism and facilitate the development of drug screening platforms for novel therapeutic targets. Here, we review the accomplishments and the current progress in human neurological disorders by using i PSC modeling for Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders, which include Timothy syndrome, Fragile X syndrome, Angelman syndrome, Prader-Willi syndrome, PhelanMc Dermid, Rett syndrome as well as Nonsyndromic Autism. | Fabiele B Russo Fernanda R Cugola Isabella R Fernandes Graciela C Pignatari Patricia C B Beltrão-Braga | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 2 | Influence of wavelength on fractionation in laser ablation ICP-MS 显示文摘 | Russo R E Mao X L Borisov 0 V Liu H C | 2000 | Journal of Analytical Atomic Spectrometry2000，15，： | 1 |
| 3 | Palmitoylethanolamideprotects against the amyloid-β25-35-induced learning and memoryimpairment in mice, an experimental model of Alzheimerdisease显示文摘 | D'Agostino G Russo R Avagliano C | 2012 | Neuropsychopharmacology2012，37，7： | 1 |
| 4 | Neuroprotection by leptin in a rat model of permanent cerebral ischemia:effects on STAT3 phosphorylation in discrete cells of the brain显示文摘 | Amantea D Tassorelli C Russo R | 2011 | Cell Death Dis2011，，2： | 1 |
| 5 | Ammonia toxicity to fishes effect of pH on the toxicity of the toxicity of the un-ionized ammonia species 显示文摘 | THURSTON R RUSSO R C VINOGRADOV G A | 1981 | Environment Science Technology1981，，15： | 1 |
| 6 | Long-term functional evaluation of the treated kidney in a prospective series of patients who underwent laparoscopic partial nephreetomy for small renal tumors显示文摘 | Porpiglia F Fiori C Bertolo R Morra I Russo R Pic- coli G | 2012 | Eur Urol2012，62，： | 1 |
| 7 | Impact of an electronic cigarette on smoking reduction and cessation in schizophrenic smokers:a prospective 12-month pilot study显示文摘 | Caponnetto P Auditor R Russo C | | 0，，： | 1 |
| 8 | The infiluence of the frequency of acoustic waves on sound-assisted fluidized of bed of fine particles显示文摘 | Russo R Chironet C Massimilla L | 1995 | Powder Technology1995，82，6： | 1 |
| 9 | Cigarette smoking is associated with a greater risk of incident 89thlna in allergic rhinitis显示文摘 | Polesa R Knoke JD Russo C | 2008 | J Allergy Clin Immuno12008，121，： | 1 |
| 10 | Interaction between gfp-tagged Pseudomonas tolaasii P12 and Pleurotus eryngii 显示文摘 | Russo A Filippi C Tombolini R | 2003 | Microbiol Res2003，158，6： | 1 |
| 11 | Chronic toxicity of ammonia to rainbow trout显示文摘 | Thurston R V Russo R C Luedtke R J | 1984 | Trans Am Fish Soc1984，113，： | 1 |
| 12 | Trimmed Spearman Karbermethod for estimatingmedian lethal concentrations in toxicity bioassays显示文摘 | Hamilton M A Russo R C Thurston R V | 1977 | Environmental Science & Technology1977，11，： | 1 |
| 13 | Aqueous ammonia equilibrium calculation:Effect of pH and temperature显示文摘 | Emerson K Russo R C Lund R E | | 0，，12： | 1 |
| 14 | Acute toxicity of ammonia to rainbow trout显示文摘 | THURSTON R V RUSSO R C | 1983 | Transactions of the American Fisheries Society1983，112，： | 1 |
| 15 | Greater risk of incident asthma cases in adults with allergic rhinitis and effect of allergen immunotherapy : a retrospective cohort study 显示文摘 | Polosa R Al Delaimy WK Russo C | 2005 | Respir Res2005，6，： | 1 |
| 16 | Time-resolvedplasma diagnostics and mass removal during single-pulse laserablation显示文摘 | RUSSO R E MAO X L UU H C | 1999 | Applied Physics A1999，69，1： | 1 |
| 17 | Structure and dynamics of Antarctic fish neuroglobin assessed by computer simulations显示文摘 | Boron I Russo R Boechi L Cheng CHC di Prisco G Estrin DA Verde C Nadra AD | | 0，，： | 1 |
| 18 | Variability in tissue characterization of atherosclerotic plaque by intravascular ultrasound:a comparison of four intravascular ultrasound systems显示文摘 | HIRO T LEUNG C Y RUSSO R J | 1996 | Am J Card Imaging1996，10，4： | 1 |
| 19 | Ciga- rette smoking is assoeiated with a greater risk of inci- dent asthma in allergic rhinitis显示文摘 | POLOSA R KNOKE J D RUSSO C | 2008 | J Allergy Clin Im- munol2008，121，： | 1 |
| 20 | Thoracic radiculopathy显示文摘 | O'CONNOR R C ANDARY M T RUSSO R B | 2002 | Phys Med Rehabil Clin N Am2002，13，3： | 1 |
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