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| 1 | FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts显示文摘AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated with poor TTP [hazard ratio (HR): 16.036, P < 0.0001] and OS (HR: 4.003, P = 0.004). CONCLUSION: The FOLFIRI regimen had an acceptable toxicity and an interesting efficacy in our study, limited to patients in good condition (PS 0-1). | Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 2 | Financial lnterrnediation and Economic Performance: Historical Evidence from Five Industrialized Countries显示文摘 | Rousseau P L Wachtel P | 1998 | Journal of Money Credit and Banking1998，30，3： | 1 |
| 3 | Violating the psychological contract: Not the exception but the norm显示文摘 | Robinson S L Rousseau D M | 1994 | Journal of Organizational Behavior1994，15，： | 1 |
| 4 | Uncited papers, uncited authors and uncited topics: A case study in library and information science显示文摘 | Liang L Rousseau R Zhong Z | 2015 | Journal of Informetrics2015，9，1： | 1 |
| 5 | A Comparison of HMO Efficiencies as a Function of Provider Autonomy 显示文摘 | Patrick L Brockett Ray E Chang John J Rousseau | 2004 | The Journal of Risk and Insurance2004，71，1： | 1 |
| 6 | Estimation of tree canopy leaf area index by gap fraction analysis显示文摘 | Martens S N Ustin S L Rousseau R A | 1993 | Forest Ecology and Management1993，61，12： | 1 |
| 7 | A rhythm indicator for science and the rhythm of Science 显示文摘 | Liang L Rousseau R Shi F | 2006 | Scientometrics2006，68，3： | 1 |
| 8 | Model-based design of horizontal subsurface flow constructed treatment wetlands: A review显示文摘 | Rousseau D P L Vanrolleghem P A Pauw N D | 2004 | Water Research2004，38，6： | 1 |
| 9 | Influence of temperature and clays/emulsion microstructure on oilbased mud low shear rate rheology显示文摘 | Herzhaft B Rousseau L Neau L | | 0，，03： | 1 |
| 10 | Violating the psychological contract:Not the exception but the norm显示文摘 | Robinson S L D M Rousseau | | 0，，03： | 1 |
| 11 | Methods for accrediting publications to authors or countries: consequences for evaluation studies 显示文摘 | EGGHE L ROUSSEAU R VAN HOOYDONK G | 2000 | Journal of the American Society for Information Science2000，51，2： | 1 |
| 12 | Accumulation of metals in the sediment and reed biomass of a combined constructed wetland treating domestic wastewater显示文摘 | Lesage E Rousseau D P L Meers E | 2007 | Water Air and Soil Pollution2007，183，： | 1 |
| 13 | Amino-termi-nal form of parathyroid hormone (PTH) with immunologicsimilarities to hPTH(l-84) is overproduced in primaryand secondary hyperparathyroidism显示文摘 | D’Amour P Brossard JH Rousseau L | 2003 | Clin Chem2003，49，12： | 1 |
| 14 | Accumulation of metals in the sediment and reed biomass of a combined constructed wetland treating domestic wastewater显示文摘 | Lesage E Rousseau D P L Meers E | 2007 | Water Air & Soil Pollution2007，183，14： | 1 |
| 15 | Constructed wetlands in Flanders : a performance analysis 显示文摘 | Rousseau D P L Vanrolleghem P A Pauw N | 2004 | Ecol Eng2004，23，3： | 1 |
| 16 | Effects of nasal pressure support on ventilation and inspiratory work in normocapnic and hypercapnic patients with stable COPD显示文摘 | Vanpee D El Khawand C Rousseau L | 2002 | Chest2002，122，1： | 1 |
| 17 | Advanced etching of silicon based on deep reactive ionetching for silicon high aspect ratio microstructures andthree-dimensional micro- and nanostructures 显示文摘 | MARTY F ROUSSEAU L SAADANY B | 2005 | Microelectronics Journal2005，36，7： | 1 |
| 18 | Scheduling and routing of automated guided vehicles: a hybrid approach 显示文摘 | CORRE'A A I LAGEVIN A ROUSSEAU L M | 2007 | Computers : Operations Research2007，34，6： | 1 |
| 19 | The permanent effects of innova- tion on financial depth: Theory and US historical evidence from unobservable components models显示文摘 | PETER L ROUSSEAU | 1998 | Journal of Mo- netary Economics1998，42，2： | 1 |
| 20 | The influence of publication delay on the observed aging distribution of scientific literatures 显示文摘 | Egghe L Rousseau R | 2000 | Journal of the American Society for Information Science2000，，2： | 1 |
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