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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 3 | Why momentum width matters for atom interferometry with Bragg pulses显示文摘 | S S Szigeti J E Debs J J Hope N P Robins J D Close | 2012 | New Journal of Physics2012，，2： | 2 |
| 4 | Uric acid and urea in relation to protein catabolism in long-term fasting geese显示文摘 | ROBIN J P CHEREL Y GIRARD H | 1987 | Journal of Comparative Physiology B:Biochemical Systemic and Environmental Physiology1987，157，4： | 1 |
| 5 | Predicting the flexural loaddeflection response of steel fibre reinforced concrete from strain, crack-width,fibre pull-out and distribution data 显示文摘 | Jones P A Austin S A Robins P J | 2008 | Materialsand Structures2008，41，3： | 1 |
| 6 | Turning, compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | E1 Kader N A Robin P Paillat J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 7 | Lintnerized Starches Gel Filtration and Enzymatic Studies of Insoluble Residues from Prolonged Acid Treatment of Potato Starch 显示文摘 | Robin J P Mercier C Charbonniere R | 1974 | Cereal Chem1974，51，： | 1 |
| 8 | Web reinforcement effects on deep beams 显示文摘 | Kong F K Robins P J Cole D F | 1970 | ACI Journal Proceedings1970，67，12： | 1 |
| 9 | The effect of lateral pressure on the bond of round reinforcing bars in concrete 显示文摘 | Robins P J Standish I G | 1982 | International Journal of Adhesion and Adhesives1982，2，2： | 1 |
| 10 | Deep beams with inclined web reinforcement 显示文摘 | Kong F K Robins P J Kirby D P | 1972 | ACI Journal Proceedings1972，69，3： | 1 |
| 11 | Doppler ultrasound color flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Robin J M | 1990 | Ultrasond Med Biol1990，16，： | 1 |
| 12 | Silicone-based polymer blends: An overview of the materials and processes 显示文摘 | LUCAS P ROBIN J J | 2007 | Functional Materials and Biomaterials2007，209，： | 1 |
| 13 | Generation of cytotoxic T lymphocytes to autologous human leukemia cells by sensitization to pooled aUogeneic normal cells显示文摘 | Zarling J M Robins H I Raich P C | 1978 | Nature(Lond)1978，274，： | 1 |
| 14 | Turning,compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | EL KADER N A ROBIN P PAILLAT J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 15 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 16 | Silicone-based polymer blends: an overview of the materials and processes 显示文摘 | LUCAS P ROBIN J J | 2007 | Advances in Polymer Science: Functional Materials and Biomaterials2007，209，： | 1 |
| 17 | EIS study of Ti-23Ta alloy in artificial saliva显示文摘 | ROBIN A MERIRELIS J P | 2009 | Corrosion Engineering Science and Technology2009，44，5： | 1 |
| 18 | Landslides: Risk perception and acceptance 显示文摘 | Finlay P J Robin Fell | 1997 | Canadian Geotechnical Journal1997，34，2： | 1 |
| 19 | The internal head protein Gpl6 controls DNA ejection from the bacteriophage T7 virion显示文摘 | Struthers-Schlinke J S Robins W P Kemp P | 2000 | J Mol Biol2000，301，： | 1 |
| 20 | Spatio-temporal analysis of commercial trawler data using general additive models: patterns of Loliginid squid abundance in the north-east Atlantic 显示文摘 | Denis V Lejeune J Robin J P | 2002 | ICES Journal of Marine Science2002，59，3： | 1 |
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