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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | β-catenindysregulation in thyroid neoplasms:down-regulation,aberrantnuclear expression,and CTNNBl exon 3 mutations are markers foraggressive tumor phenotypes and poor prognosis显示文摘 | Garcia-Rostan G Camp RL Herrero A | 2001 | Am J Pathol2001，158，3： | 1 |
| 3 | X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization 显示文摘 | Camp RL Dolled-Filhart M Rimm DL | 2004 | Clinical cancer research : an official journal of the American Association for Cancer Research2004，10，21： | 1 |
| 4 | A new autosomal recessive form of Stickler syndrome is caused by a mutation in the COL9A1 gene 显示文摘 | Van Camp G Snoeckx RL Hilgert N van den Ende J Fukuoka H Wagatsuma M | 2006 | Am J Hum Genet2006，79，3： | 1 |
| 5 | Punctate LC3 B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome 显示文摘 | Lazova R Camp RL Klump V | 2012 | Clin Cancer Res2012，18，2： | 1 |
| 6 | Tissue microarray:a new technology for amplification of tissue resources显示文摘 | Rimm DL Camp RL Charette LA | 2001 | Cancer J2001，7，1： | 1 |
| 7 | Automated subcellular localizationand quantification of protein expression in tissue microarrays显示文摘 | Camp RL Chung GG Rimm DL | 2002 | Nat Med2002，8，11： | 1 |
| 8 | Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer显示文摘 | Camp RL Giltnane JM | 2008 | Breast Cancer Res2008，10，： | 1 |
| 9 | Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer显示文摘 | Nadler Y Camp RL Schwartz C | 2008 | Clin Canc- er Res2008，14，14： | 1 |
| 10 | Betacatenin dysregulation in thyroid neoplasms:down-regulation,aberrant nuclear expression,and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis显示文摘 | Camp RL Herrero A | 2001 | Am J Pathol2001，158，3： | 1 |
| 11 | Automated subcellular local-ization and quantification of protein expression in tissue microarrays显示文摘 | Camp RL Chung GG Rimm DL | 2002 | Nat Med2002，8，11： | 1 |
| 12 | Lymph node ratio should be considered for incorporation into staging for breast cancer显示文摘 | Chagpar AB Camp RL Hiram DL | 2011 | Ann Surg Oncol2011，18，11： | 1 |
| 13 | ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer显示文摘 | Garcia-Kostan G Zhao H Camp RL | 2003 | Clin Oncd2003，21，17： | 1 |
| 14 | Tissue mieroarray : a new technology for amplification of tissue resources 显示文摘 | Rimm DL Camp RL Charette LA | 2001 | Cancer J2001，7，1： | 1 |
| 15 | Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer显示文摘 | Nadler Y Camp RL Schwartz C | 2008 | Clin Cancer Res2008，14，14： | 1 |
| 16 | Lymph node ratio should be considered for incorporation into staging for breast cancer显示文摘 | Chagpar AB Camp RL Rimm DL | 2011 | Ann Surg Oncol2011，18，11： | 1 |
| 17 | Aneurysmal bone cyst of the spine with familial incidence显示文摘 | Murphy MJ Camp RL | 2000 | Spine2000，25，： | 1 |
| 18 | Amplification of tissue by construction of tissue microarrays 显示文摘 | Rimm DL Camp RL Charette LA | 2001 | Exp Mol Pathol2001，70，3： | 1 |
| 19 | Validation of tissue microarrays techrology in breast carcinoma显示文摘 | Camp RL Charette LA Rimn DL | 2000 | Lab Invest2000，80，12： | 1 |
| 20 | Expression patterns and prognostic value of Bag-- 1 and Bcl-- 2 in breast cancer显示文摘 | Nadler Y Camp RL Giltnane JM | 2008 | Breast Cancer Res2008，10，2： | 1 |
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