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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Review of inverse analysis for indirect measurement of impact force显示文摘 | Inoue H Harrigan J J Reid S R | 2001 | Applied Mechanics Review2001，54，6： | 2 |
| 3 | The crushing strength of aluminium alloy form at high rates of strain显示文摘 | Reid S R Tan P J Harrigan J J | 2001 | Impact Engineering and Application2001，2，： | 2 |
| 4 | Axial splitting of circular metal tubes显示文摘 | Reddy T Y Reid S R | 1986 | Int J mech sci1986，111，28： | 2 |
| 5 | Indentation penetration and perforation of composite laminates and sandwich panels under quasi-static and projectile loading显示文摘 | Wen H M Reddy T Y Reid S R | 1998 | Key Eng Mater1998，，1： | 1 |
| 6 | Local impact effects of hard missiles on concrete targets 显示文摘 | LI Q M REID S R WEN H M | 2005 | Int J Impact Eng2005，32，： | 1 |
| 7 | Large deformations of thin-walled circular tubes under transverse loading 显示文摘 | Thomas S G Reid S R Johnson W | 1976 | International Journal of Mechanical Sciences1976，18，6： | 1 |
| 8 | Impact loading of plates and shells by free-flying projectiles: A review显示文摘 | Corbett G G Reid S R Johnson W | 1996 | International Journal of Impact Engineering1996，18，： | 1 |
| 9 | Leaf senescence and lipid peroxidation: Effects of some phytohormones,and scavengers of free radicals and singlet oxygen显示文摘 | Dhindsa R S Plumb-Dhindsa P L Reid D M | 1982 | Physiol Plantarum1982，56，： | 1 |
| 10 | Static and dynamic crushing of foam-filled sheet metal tubes 显示文摘 | Reid S R Reddy T Y Gray M D | 1986 | Int J Mech Sci1986，28，5： | 1 |
| 11 | Penetration and perforation of composite sandwich panels by hemispherical and conical projectiles显示文摘 | Reddy T Y Wen H M Reid S R | 1998 | Trans ASME J Pres Ves Tech1998，120，2： | 1 |
| 12 | Impact loading of plates and shells by free-flying projectiles:A review显示文摘 | Corbett G G Reid S R Johnson W | 1996 | International Journal of Impact Engineering1996，18，2： | 1 |
| 13 | Impact loading of plates and shells by free flying projectiles: A review显示文摘 | Corbett G G Reid S R Johnson W | 1996 | In-ternational Journal of Impact Engineering1996，18，2： | 1 |
| 14 | In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain显示文摘 | Fallon J Reid S Kinyamu R | 2000 | Proc Natl Acad Sci USA2000，97，14： | 1 |
| 15 | Deformation and failure of clamped beams under low speed impact loading 显示文摘 | Wen H M Reddy T Y Reid S R | 1995 | Int J Impact Eng1995，16，3： | 1 |
| 16 | Spatial trypanosomosis management: from data-layers to decision making 显示文摘 | Hendrickx G de La Rocque S Reid R | 2001 | Trends Para- sitol2001，17，1： | 1 |
| 17 | High-temperature self-circulating thermoacoustic heat exchanger 显示文摘 | Backhaus S Swift G W Reid R S | 2005 | APPLIED PHYSICS LETTERS2005，，： | 1 |
| 18 | The use of the splitHopkinson pressure bar techniques in high strain rate mate-rials testing显示文摘 | Al-Mousawi M M Reid S R Deans W F | 1997 | Proceedings of the Institution of MechanicalEngineers Part C:Journal of Mechanical Engineering Sci-ence1997，211，4： | 1 |
| 19 | 显示文摘 | BLAKENEY J S REID R C FAIRLIE D P | 2007 | Chem Rev2007，107，： | 1 |
| 20 | Phosphorus uptake by plants : From soil to cell 显示文摘 | Schachtman D P Reid R J Ayling S M | 1998 | Plant Physiology1998，116，： | 1 |
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