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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | A tran sient two-dimensional finite volume model for the simulation of vertical U-tube ground heat exchanges 显示文摘 | YAVUZTURK C SPLITLER J D REES S J | 1999 | ASHRAE Transactions1999，105，2： | 1 |
| 3 | The Stability of Lactic Acid Production in Resting Suspensions of Lactobacillus Delbrueeckii显示文摘 | REES J F PIRT S J | 1979 | Journal of Chemical Technology and Biotechnology1979，29，9： | 1 |
| 4 | Temporal variability of denitrification in estuarine sediments显示文摘 | LAW C S REES A P OWENS N J P | 1991 | Estuarine Coastal and Shelf Science1991，33，1： | 1 |
| 5 | Nitrous oxide: Estuarine sources and atmospheric flux 显示文摘 | LAW C S REES A P OWENS N J P | 1992 | Estuarine Coastal and Shelf Science1992，35，3： | 1 |
| 6 | A survey of standing column well installations in North America 显示文摘 | ORIO C D JOHNSON C N REES S J | 2005 | ASHRAE Transactions2005，111，2： | 1 |
| 7 | A preliminary assessment of the effects of groundwater flow on closed-loop ground-source heat pump systems 显示文摘 | CHIASSON A D REES S J SPITLER J D | 2000 | ASHRAE Trans2000，106，1： | 1 |
| 8 | A transient two-dimensional finite volume model for the simulation of vertical U-tube ground heat exchanges显示文摘 | Yavuzturk C Splitler J D Rees S J | 1999 | ASHRAE Transaction1999，105，2： | 1 |
| 9 | A model for sim- dating the performance of a pavement heating system as a supplemental heat rejecter with closed loop ground source heat pump systems 显示文摘 | Chiasson A D Spitler J D Rees S J | 2000 | ASME Journal of Solar Energy Engineering2000，122，11： | 1 |
| 10 | A nodal model for displacement ventilation and chilled ceiling systems in office spaces显示文摘 | S J Rees P Havas | 2001 | Building and Environment2001，36，6： | 1 |
| 11 | Systemic arterial supply to the lungs in pulmonary atresia and its relation to pulmonary artery development显示文摘 | Jefferson K Rees S Somerville J | 1972 | Br Heart J1972，34，4： | 1 |
| 12 | Matrix Representation of Topological Changes in Metamorphic Mechanisms显示文摘 | DAI J S REES J J | 2005 | Transactions of the ASME: Journal of Mechanical Design2005，127，4： | 1 |
| 13 | A model for sim-ulating the performance of a shallow pond as a supple- mental heat rejecter with closed loop ground source heat pump systems 显示文摘 | Chiasson A D Spitler J D Rees S J | 2000 | ASHRAE Transactions2000，106，2： | 1 |
| 14 | A preliminary assessment of the effects of groundwater flow on closed-loopground-source heat pump systems显示文摘 | CHIASSON A D REES S J SPITLER J D | 2000 | ASHRAE Transactions2000，106，1： | 1 |
| 15 | A cross-sectional study of dentine hypersensitivity显示文摘 | REES J S ADDY M | 2002 | J Clin Periodontol2002，29，11： | 1 |
| 16 | Structure and properties of various poly(amic diisopropyl ester-altimide) s and their alternating eopolyimides显示文摘 | KIM S I SHIN T J REE M | 2000 | Poly mer2000，41，： | 1 |
| 17 | Oxidative modifications and aggregation of Cu, Zn-superoxide dismutase associated with Alzheimer and Parkinsen diseases 显示文摘 | Choi J Rees H D Weintraub S T | 2005 | J Biol Chem2005，，11： | 1 |
| 18 | Mobility in metamorphic mechanisms of foldable/erectable kinds显示文摘 | Dai J S Rees Jones J | | 0，，03： | 1 |
| 19 | A Model for Simulating the Performance of a Shallow Pond as a Supplemental Heat Rejecter with Closed-Loop Ground-Source Heat Pump Systems 显示文摘 | Chiasson A D Spitler J D Rees S J | 2000 | ASHRAE transactions2000，106，2： | 1 |
| 20 | A three-dimensional numerical mod- el of borehole heat exchanger heat transfer and fluid flow显示文摘 | Rees S J He M | 2013 | Geothermics2013，46，： | 1 |
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