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| 1 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | With increasing trends of prostate cancer in the Saudi Arabia and Arab World: Should we start screening programs?显示文摘Incidence rate for prostate cancer in the Arab World is significantly lower than United States and Europe, it ranges from 5.5% to 39.2%. However, the incidence and the number of deaths is expected to increase. In Saudi Arabia, the crude incidence rate and age standardized incidence rate of prostate cancer are reported to be steadily increasing in between 2001-2008. Only two screening trials were attempted in 2001 and 2009 which yielded an incidence rate of 1.17% and 2.5% respectively. Men in the Arab world are sharing a common characteristic of poor knowledge and poor attitude towards prostate cancer examination and screening practices. They are ill-informed about the PSA test's strengths and drawbacks because the doctors are not talking to them about the importance of counselling. Men should be encouraged to do PSA testing before the age of 50 and till the age of 70 years. This could be achieved by enhancing their attitude and enriching the knowledge of the physicians towards PSA testing, harms and benefits, through shared decision making, which would increase men's knowledge scores, reduced their decisional conflict and promote greater involvement in decision making. | Mostafa A Arafa Danny M Rabah | 2017 | World Journal of Clinical Oncology2017，8，6： | 4 |
| 3 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 4 | On-board measurement of emissions from liquefied petroleum gas,gasoline and diesel powered passenger cars in Algeria显示文摘On-board measurements of unit emissions of CO,HC,NOx and CO2 were conducted on 17 private cars powered by different types of fuels including gasoline,dual gasoline–liquefied petroleum gas(LPG),gasoline,and diesel. The tests performed revealed the effect of LPG injection technology on unit emissions and made it possible to compare the measured emissions to the European Artemis emission model. A sequential multipoint injection LPG kit with no catalyst installed was found to be the most efficient pollutant reduction device for all of the pollutants,with the exception of the NOx. Specific test results for a sub-group of LPG vehicles revealed that LPG-fueled engines with no catalyst cannot compete with catalyzed gasoline and diesel engines. Vehicle age does not appear to be a determining parameter with regard to vehicle pollutant emissions. A fuel switch to LPG offers many advantages as far as pollutant emissions are concerned,due to LPG's intrinsic characteristics.However,these advantages are being rapidly offset by the strong development of both gasoline and diesel engine technologies and catalyst converters. The LPG's performance on a chassis dynamometer under real driving conditions was better than expected. The enforcement of pollutant emission standards in developing countries is an important step towards introducing clean technology and reducing vehicle emissions. | Saadane Chikhi Ménouèr Boughedaoui Rabah Kerbachi Robert Joumard | 2014 | Journal of Environmental Sciences2014，26，8： | 2 |
| 5 | Nitrate removal characteristics of high performance fluidized-bed biofilm reactors 显示文摘 | Rabah F K J Dahab M F | 2004 | War Res2004，38，： | 1 |
| 6 | Nitrate removalcharacteristics of high performance fluidized-bed biofilmreactors 显示文摘 | Rabah F K J Dahab M F | 2004 | Water Research2004，38，19： | 1 |
| 7 | Recovery of zinc and some of its valuables salts from secondary resources and wastes显示文摘 | RABAH M A EL-SAYED A S | 1995 | Hydrometallurgy1995，37，1： | 1 |
| 8 | Hydrometallurgical recovery of metal values from brass melting slag显示文摘 | Abdel Basir S M Mahmoud A Rabah | 1999 | Hydrometallurgy1999，53，： | 1 |
| 9 | Biofilm and biomass characteristics in high-performance fluidized-bed biofilm reactors 显示文摘 | Rabah F K J Dahab M F | 2004 | Water Res2004，38，19： | 1 |
| 10 | A novel method of marking nipple areola complex in gynaecomastia surgery 显示文摘 | WANI S A RABAH S M ALFADIL S | 2015 | Indian J Plast Surg2015，48，1： | 1 |
| 11 | Redo pullthrough for Hirschsprung disease: A single surgical group's experience 显示文摘 | Ralls M W Freeman J J Rabah R | 2014 | J Pediatr Surg2014，49，9： | 1 |
| 12 | Insights into the Formation Mechanisms of Si-OR Monolayers from the Thermal Reactions ofAlcohols and Aldehydes with Si(111)-H1显示文摘 | Rabah B Sylvie M Paula S | 2000 | Langmuir2000，16，： | 1 |
| 13 | First- principle study of structural, electronic and elastic properties of beryllium chalcogenides BeS, BeSe and BeTe 显示文摘 | Rached D Rabah M Benkhettou N | 2006 | Compt Mater Sci2006，37，3： | 1 |
| 14 | Calculated band structures and optical properties of lead chalco- genides PbX (X = S, Se, Te) under hydrostatic pressure 显示文摘 | Raehed D Rabah M Benkhettou N | 2003 | Physiea B: Condensed Matter2003，337，14： | 1 |
| 15 | Impact of Information and Communication Technologies on Logistics and Freight Transportation:Example of Vendor-Managed Inventories显示文摘 | M Rabah H S Mahmassani | | 0，，： | 1 |
| 16 | First-principles calculations of structural, elastic and electronic properties of Ni(2)MnZ (Z=A1, Ga and In) Heusler alloys显示文摘 | RACHED H RACHED D KHENATA R RESHAK ALI H RABAH M | 2009 | Physica Status Solidi B2009，246，7： | 1 |
| 17 | Recovery of nickel, cobalt and some salts from spent Ni-MH batteries显示文摘 | Rabah M A | 2007 | Waste Management2007，13，： | 1 |
| 18 | Post varicella thrombosis-report of 2 cases and literature review显示文摘 | Rabah F E1-Banna N Abdel-Baki M Beshalwi I Macaraig D Bhuyan D | 2012 | Pediatr Infect Dis J2012，31，9： | 1 |
| 19 | Design and field testing of Savonius wind pump in east Africa显示文摘 | Rabah K V O Osawa B M | 1996 | Int J of Arab En1996，17，2： | 1 |
| 20 | Sedimentological evolution of the Givetian-Eifelian(F3) sand bar of the West Alrar field, lUizi Basin, Algeria显示文摘 | Rabah Chaouchi Malla M S Kechou F | 1998 | Geological Society Special Publication1998，132，： | 1 |
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