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| 1 | Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep显示文摘Background: Polyamines stimulate DNA transcription and m RNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and survival of conceptuses(embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine(Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase(ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine. In the non-classical pathway, Arg is converted to agmatine(Agm) by arginine decarboxylase(ADC), and Agm is converted to putrescine by agmatinase(AGMAT).Methods: Morpholino antisense oligonucleotides(MAOs) were designed and synthesized to inhibit translational initiation of the m RNAs for ODC1 and ADC, in ovine conceptuses.Results: The morphologies of MAO control, MAO-ODC1, and MAO-ADC conceptuses were normal. Double knockdown of ODC1 and ADC(MAO-ODC1:ADC) resulted in two phenotypes of conceptuses; 33% of conceptuses appeared to be morphological y and functional y normal(phenotype a) and 67% of the conceptuses presented an abnormal morphology and functionality(phenotype b). Furthermore, MAO-ODC1:ADC(a) conceptuses had greater tissue concentrations of Agm,putrescine, and spermidine than MAO control conceptuses, while MAO-ODC1:ADC(b) conceptuses only had greater tissue concentrations of Agm. Uterine flushes from ewes with MAO-ODC1:ADC(a) had greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with MAO-ODC1:ADC(b) conceptuses had lower amount of putrescine, spermidine, spermine, alanine, aspartate,glutamine, tyrosine, phenylalanine, isoleucine, leucine, and lysine.Conclusions: The double-knockdown of translation of ODC1 and ADC m RNAs was most detrimental to conceptus development and their production of interferon tau(IFNT). Agm, polyamines, amino acids, and adequate secretion of IFNT are critical for establishment and maintenance of pregnancy during the peri-implantation period of gestation in sheep. | Yasser Y.Lenis Gregory A.Johnson Xiaoqiu Wang Wendy W.Tang Kathrin A.Dunlap M.Carey Satterfield Guoyao Wu Thomas R.Hansen Fuller W.Bazer | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 3 |
| 2 | A forecast comparison of volatility models: does anything beat a GARCH(1,1)?显示文摘 | Peter R.Hansen AsgerLunde | 2005 | J Appl Econ2005，，7： | 1 |
| 3 | A forecast comparison of volatility models: does anything beat a GARCH(1,1)?显示文摘 | Peter R.Hansen AsgerLunde | 2005 | J Appl Econ2005，，7： | 1 |
| 4 | Homocysteine and the production of collagens, proliferation and apoptosis in human arterial smooth muscle cells显示文摘 | LARS M.RASMUSSEN PETER R.HANSEN THOMASLEDET | 2004 | APMIS2004，，9： | 1 |
| 5 | Neutrophil Gelatinase‐Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM1) in patients with diabetic nephropathy: a cross‐sectional study and the effects of lisinopril显示文摘 | S. E.Nielsen K. J.Schjoedt A. S.Astrup L.Tarnow M.Lajer P. R.Hansen H.‐H.Parving P.Rossing | 2010 | Diabetic Medicine2010，，10： | 1 |
| 6 | A forecast comparison of volatility models: does anything beat a GARCH(1,1)?显示文摘 | Peter R.Hansen AsgerLunde | 2005 | J Appl Econ2005，，7： | 1 |
| 7 | A forecast comparison of volatility models: does anything beat a GARCH(1,1)?显示文摘 | Peter R.Hansen AsgerLunde | 2005 | J Appl Econ2005，，7： | 1 |
| 8 | Schwannomas provide insight into the role of p75^(NTR) and merlin in Schwann cells following nerve injury and during regeneration显示文摘Peripheral nerve injury leads to Wallerian degeneration of severed axons,leaving the Schwann cell(SC)sheath behind.Denervated SCs may then either survive and remyelinate a regenerating axon,or they may undergo cell death.Because SCs provide trophic support and guidance cues to regenerating nerve fibers,SC loss severely hampers nerve regeneration(Hall,1986).Thus,significant work has sought to characterize the | Elise Cheng Marlan R.Hansen | 2016 | Neural Regeneration Research2016，11，1： | 0 |
| 9 | Development of a Functional Assessment of Chronic Illness Therapy item library and primary symptom list for the assessment of patient-reported adverse events associated with immune checkpoint modulators显示文摘Aim:To develop a comprehensive item library of patient-reported,immunotherapy-related adverse events(irAEs)that draws from and expands on the Functional Assessment of Chronic Illness Therapy(FACIT)Measurement System.Methods:Literature review and iterative expert input.Based on a literature review of irAEs,we developed a framework of immunotherapy classes and their associated symptoms.Clinical experts then reviewed iterations of symptom summaries and item maps linked to the immunotherapy framework.Experts provided content review and feedback was shared across experts until consensus was reached.The iterative process facilitated creation of a Primary Symptom List associated with immune checkpoint modulators(ICMs),drawn from the larger set of symptoms.Existing FACIT items were mapped to the symptom list,and new items were written as needed to create the item library.Results:The full item library of irAEs is comprised of 239 items,covering 142 unique symptoms across 75 inflammatory reactions/immune conditions.A subset of 66 items comprises a Primary Symptom List considered most common/relevant to ICM treatment.This includes gastrointestinal,skin,pulmonary,neurologic,musculoskeletal,and multiple miscellaneous and constitutional symptoms.Conclusion:The FACIT Immunotherapy Item Library is a compilation of 239 self-report items that capture the wide range of AEs experienced by people receiving immune treatments.A subset of 66 items comprises a Primary Symptom List meant for ICM therapy.Use of items selected from this library is encouraged in clinical research and clinical practice evaluation. | Kimberly A.Webster Mary L.O’Connor Aaron R.Hansen Sheetal Kircher Heather S.L.Jim Adam P.Dicker Monika Janda Kari Ala-leppilampi Clifton O.Bingham III Josephine Feliciano Norah Lynn Henry Laurie E.Steffen McLouth David Cella | 2020 | Journal of Cancer Metastasis and Treatment2020，6，1： | 0 |
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