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| 1 | Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer显示文摘AIM: To identify suitable biomarkers of response to bevacizumab(BV)- it remains an open question. The measurement of serum vascular endothelial growth factor(VEGF) has been proposed as a predictive factor for this drug, even if literature data are contradictory. METHODS: We prospectively evaluated the role of BV, total and not BV-bound VEGF and angiopoietin-2(Ang-2) serum levels as potential predictive factors of response for BV in combination with an oxaliplatinbased chemotherapy. BV, Ang-2, total and not BVbound VEGF levels were measured at baseline, before 2^(nd) and 5^(th) cycle of oxaliplatin-based chemotherapy in 20 consecutive metastatic colorectal cancer patients. RESULTS: Results were correlated to response to treatment. Variability in BV levels have been found, with decreased level in less responding patients. In particular, the concentration of BV increased of 3.96 ± 0.69 folds in serum of responsive patients after 3 more cycles of therapy compared to those with stable or progressive disease with a 0.72 ± 0.25 and 2.10 ± 0.13 fold increase, respectively. The determination of free and total VEGF demonstrated that the ratio between the two values, evaluated immediately before the 2^(nd) and the 5^(th) cycle of therapy, decreased from 26.65% ± 1.33% to 15.50% ± 3.47% in responsive patients and from 53.41% ± 4.75 to 34.95% ± 2.88% in those with stable disease. Conversely, in those with progression of disease, the ratio showed the opposite behavior coming up from 25.99% ± 5.23% to 51.71% ± 5.28%. The Ang-2 levels did not show any relationship. CONCLUSION: Our data show that the ratio of not BV-bound VEGF to total VEGF serum and BV plasma concentrations for predicting the response to BV plus oxaliplatin-based chemotherapy could be a promising biomarker of response to BV. | Amalia Azzariti Letizia Porcelli Oronzo Brunetti Marzia Del Re Vito Longo Patrizia Nardulli Michele Signorile Jian-Ming Xu Angela Calabrese Anna Elisa Quatrale Evaristo Maiello Vito Lorusso Nicola Silvestris | 2016 | World Journal of Gastroenterology2016，22，27： | 4 |
| 2 | Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity显示文摘 | Letizia Porcelli Anna E. Quatrale Paola Mantuano Maria G. Leo Nicola Silvestris Jean F. Rolland Enza Carioggia Marco Lioce Angelo Paradiso Amalia Azzariti | 2013 | Molecular Oncology2013，，3： | 2 |
| 3 | Hypokaliemic rhabdomyolysis associated with liquorice ingestion:report of an atypical case显示文摘 | Barrella M Lauria G Quatrale R | 1997 | Ital J Neurol Sci1997，18，4： | 1 |
| 4 | Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity显示文摘 | Letizia Porcelli Anna E. Quatrale Paola Mantuano Maria G. Leo Nicola Silvestris Jean F. Rolland Enza Carioggia Marco Lioce Angelo Paradiso Amalia Azzariti | 2012 | Molecular Oncology2012，，： | 1 |
| 5 | The exeitability of the trigeminal motor system in sleep bruxism: a transcranial magnetic stimulation and brainstem reflex study显示文摘 | Gastaldo E Quatrale R Graziani A | 2006 | J Orofac Pain2006，20，2： | 1 |
| 6 | Clinical use of non-A botulinum toxins: botulinum toxin type C and botulinum toxin type F显示文摘 | Eleopra R Tugnoli V Quatrale R | 2006 | Neurotox Res2006，9，23： | 1 |
| 7 | Motor evoked responses to paired cortical magnetic stimulation in Parkinson's disease显示文摘 | Valzania F Strafella AP Quatrale R | 1997 | Eiectroencephalogr Clin Neurophysiol1997，105，1： | 1 |
| 8 | Neurophysiological study of corticomotor pathways in restless legs syndrome 显示文摘 | Quatrale R Manconi M Gastaldo E | 2003 | Clin Neurophysio12003，114，9： | 1 |
| 9 | EGFR tyrosine kinases inhibitors in cancer treatment:in vitro and in vivo evidence显示文摘 | Quatrale AE Porcelli L Silvestris N | | 0，，： | 1 |
| 10 | Optimize ra- diochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity 显示文摘 | Porcelli L Quatrale AE Mantuano P | 2013 | Mol Oncol2013，7，3： | 1 |
| 11 | The role of gustatory flushing in Frey’s syndrome and its treatment with botulinum toxin type A显示文摘 | V. Tugnoli R. Marchese Ragona R. Eleopra R. Quatrale J. G. Capone A. Pastore C. Montecucco D. De Grandis | 2002 | Clinical Autonomic Research2002，，3： | 1 |
| 12 | Different types of botulinum toxin in humans 显示文摘 | Eleopra R Tugnoli V Quatrale R | 2004 | Mov Disord2004，19，8： | 1 |
| 13 | The excitability of the trigeminal motor system in sleep bruxism: a transcranial magnetic stimulation and brainstem reflex study显示文摘 | Gastaldo E Quatrale R Graziani A | 2006 | J OroJac Pain2006，20，2： | 1 |
| 14 | The coordinated role of CYP450 enzymes and P gp in determining cancer resistance to chemotherapy显示文摘 | Azzariti A Porcelli L Quatrale AE | 2011 | Curr Drug Metab2011，12，8： | 1 |
| 15 | Pattern of motor evoked response to repetitive transcranial magnetic stimulation显示文摘 | Quatrale R Strafello AP | 1994 | Electroencephalogr Clin Neurophysiol1994，93，3： | 1 |
| 16 | Optimize radiochemo- therapy in pancreatic cancer: PARP inhibitors a new therapeutic oppor- tunity显示文摘 | Porcelli L Quatrale AE Mantuano P | 2013 | ]Viol Oncol2013，7，3： | 1 |
| 17 | Different types ofbotulinum toxin in humans显示文摘 | Eleopra R Tugnoli V Quatrale R | 2004 | Mov Disord2004，19，8： | 1 |
| 18 | Synergistic antipro- liferative and antiangiogenic effects of EGFR and roTOR inhibitors 显示文摘 | Porcelli L Quatrale AE Mantuano P | 2013 | Gun-Pharm Des2013，19，5： | 1 |
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