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| 1 | Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region显示文摘Recommendations for probiotics are available in several regions. This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed. Evidence-based recommendations and randomized controlled trials in the region were revised. Cultural aspects,health management issues and economic factors were also considered. Final recommendations were approved by applying the Likert scale and rated using the GRADE system. Saccharomyces boulardii CNCM I-745(Sb) and Lactobacillus rhamnosus GG(LGG) were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis. Lactobacillus reuteri could also be considered. Probiotics may be considered for prevention of(with the indicated strains): antibiotic-associated diarrhea(LGG or Sb); Clostridium difficile-induced diarrhea(Sb); nosocomial diarrhea(LGG); infantile colic(L reuteri) and as adjunct treatment of Helicobacter pylori(Sb and others). Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries. These need to be validated with local randomized-controlled trials. | Donald Cameron Quak Seng Hock Musal Kadim Neelam Mohan Eell Ryoo Bhupinder Sandhu Yuichiro Yamashiro Chen Jie Hans Hoekstra Alfredo Guarino | 2017 | World Journal of Gastroenterology2017，23，45： | 14 |
| 2 | Rapid detection of Enterovirus 71 by real-time TaqMan RT-PCR显示文摘 | Eng Lee Tan Li Li Gaynor Yong Seng Hock Quak Wei Cheng Andrea Yeo Vincent Tak Kwong Chow Chit Laa Poh | 2008 | Journal of Clinical Virology2008，，2： | 1 |
| 3 | Rapiddetection of Enterovirus 71 by real -time TaqMan RT -PCR 显示文摘 | Eng Lee Tan Li Li Gaynor Yong Seng Hock Quak | 2008 | Clinical Virology2008，42，： | 1 |
| 4 | Functional Gastrointestinal Disorders: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition显示文摘 | Jeffrey Hyams Richard Colletti Christophe Faure Elizabeth Gabriel-Martinez Helga Verena L. Maffei Mauro B. Morais Quak Seng Hock Yvan Vandenplas | 2002 | Journal of Pediatric Gastroenterology and Nutrition2002，，： | 1 |
| 5 | Rapid detection of Enterovirus 71 by real-time TaqMan RT-PCR显示文摘 | Eng Lee Tan Li Li Gaynor Yong Seng Hock Quak Wei Cheng Andrea Yeo Vincent Tak Kwong Chow Chit Laa Poh | 2008 | Journal of Clinical Virology2008，，2： | 1 |
| 6 | 婴儿配方粉成分的全球标准:欧洲儿科胃肠病、肝病和营养学会牵头的国际专家组建议显示文摘 | Berthold Koletzko Susan Baker Geoff Cleghorn Ulysses Fagundes Neto Sarath Gopalan Olle Hernell Quak Seng Hock Pipop Jirapinyo Bo Lonnerdal Paul Pencharz Hildegard Pzyrembel Jaime Ramirez-Mayans Raanan Shamir Dominique Turck Yuichiro Yamashiro 丁宗一(译) 无 | 2006 | 中国循证儿科杂志2006，1，4： | 1 |
| 7 | Cyclical vomiting syndrome: Recognition, assessment and management显示文摘Cyclical vomiting syndrome(CVS) is a functional, debilitating disorder of childhood frequently leading to hospitalization. Affected children usually experience a stereotypical pattern of vomiting though it may vary between different individuals. The vomiting is intense often bilious, and accompanied by disabling nausea. Identifiable precipitating factors for CVS include psychosocial stressors, infections, lack of sleep and occasionally even food triggers. Often, it may be difficult to distinguish episodes of CVS from other causes of acute abdomen and altered consciousness. Thus, the diagnosis of CVS remains largely one of exclusion. Investigations routinely done during the work-up of a child with suspected CVS include both blood and imaging modalities. Plasma lactate, ammonia, amino acid and acylcarnitine profiles as well as urine organic acid profile are indicated to exclude inborn errors of metabolism. The treatment remains challenging and targeted at prevention or shortening of the attacks and can be considered as abortive, supportive and prophylactic. Use of nonpharmacological therapy is also part of the management of CVS. The prognosis of CVS is variable. More insight into the pathogenesis of this disorder as well as role of non-pharmacological therapy is needed. | Michelle LN Tan Maria Janelle Liwanag Seng Hock Quak | 2014 | World Journal of Clinical Pediatrics2014，3，3： | 0 |
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