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| 1 | A proposed role for glutamine in cancer cell growth through acid resistance显示文摘 | WeijiaoHuang #x0002A WooyoungChoi #x0002A YulingChen QiZhang HaitengDeng WeiHe YigongShi | 2013 | Cell Research2013，23，5： | 11 |
| 2 | Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer显示文摘Oxaliplatin 是在 colorectal 癌症(CRC ) 的化疗的关键药。然而,它的功效由于癌症房间的药抵抗是未得到满足的。在这研究,我们测试了是否一个自然代理人, ursolic 酸,能为 CRC 提高 oxaliplatin 的功效。当在 vitro 模型,和 SW620 异种皮移植老鼠模型被使用在,包括 SW480, SW620, LoVo,和 RKO 的四根 CRC 房间线被使用进一步在里面 vivo 学习。我们发现 ursolic 酸禁止了增长并且导致了所有四个房间的 apoptosis 并且提高了 oxaliplatin 的 cytotoxicity。这效果与 Bcl-xL 的下面规定被联系, Bcl-2 , survivin , caspase-3 的激活, 8 , 9 ,并且 MAPK 的 KRAS 表示和 BRAF , MEK1/2 , ERK1/2 , p-38 , JNK , AKT , IKK , IB ,和 p65 phosphorylation 的抑制, PI3K/AKT ,并且 NF-B 发信号小径。二个代理人也在 vivo 对肿瘤生长显示出 synergistic 效果。另外, ursolic 酸恢复了与 oxaliplatin 对待的鼠标的肝函数和身体重量。因此,我们断定 ursolic 酸能在 vitro 并且在 vivo 对 CRC 提高 oxaliplatin 的治疗学的效果,它提供有效策略最小化导致 oxaliplatin 的不利事件的负担并且提供地基让新临床的策略对待 CRC。 | Jianzhen Shan Yanyan Xuan QiZhang Chunpeng Zhu Zhen Liu Suzhan Zhang | 2016 | Protein & Cell2016，7，8： | 11 |
| 3 | Free cholesterol-induced macrophage apoptosis is mediated by inositol-requiring enzyme 1 alpha-regulated activation of Jun N-terminal kinase显示文摘在先进动脉粥样硬化患者损害的巨噬细胞死亡导致 lesional 坏死,可能的匾破裂,和尖锐脉管的吸藏。巨噬细胞死亡的一个可能的原因是导致 endoplasmic 蜂窝胃的激活的免费胆固醇(FC ) 的累积(嗯) 导致压力的 apoptosis。1 alpha (IRE1 ) 是的要求肌醇的酶 ERthat 的不可分的膜蛋白质是在在巨噬细胞的导致胆固醇的 apoptosis 的关键发信号步,在 ER 由应力激活。然而,在规定的 IRE1 的角色嗯为这个过程的导致压力的巨噬细胞死亡和机制大部分是不清楚的。在这研究,一个房间文化模型被用来探索涉及导致 FC 的巨噬细胞死亡的 ER 压力小径的机制。结果此处证明巨噬细胞装载的 FC 导致部分依赖于由 IRE1 的激活的开始的 apoptotic 回答。一起拿,这些结果证明 IRE1-apoptosis-signaling kinase 1-c-Jun NH2 终端 kinase 串联小径在这个过程被要求。而且,数据在先进动脉粥样硬化患者损害为导致胆固醇的巨噬细胞死亡建议了新奇细胞的机制。这发信号的串联的批评功能被预防显示嗯在 IRE1 的抑制以后的导致压力的 apoptosis,或 c6 月 NH2 终端 kinase。 | Fangming Li Yi Guo Shenggang Sun Xin Jiang Bingshan Tang Qizhang Wang Ling Wang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 7 |
| 4 | Timosaponin derivative YY-23 acts as a non- competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice显示文摘目的: N-methyl-D-aspartic 酸(NMDA ) 受体调节的人作为潜在的抗抑郁剂代理人显示出有希望的结果,而 timosaponins 从中国植物根茎 Anemarrhenae 提取了,展出抗抑郁剂活动。在现在的学习,我们检验了是否 YY-23, timosaponin B-III 的修改代谢物,能在老鼠影响 NMDA 受体在 vitro 的海马趾的神经原,并且在强调 mice.Methods 评估了它的像抗抑郁剂的效果:导致 NMDA 的水流在尖锐地分裂的老鼠被记录用一种整个房间的记录技术的海马趾的 CA1 神经原。C57BL/6 老鼠暴露于一个 6 星期的长期的温和压力(厘米) 或 10-d 长期的社会失败应力(CSDS ) 。强调老鼠与 YY-23 被对待(20 mg· kg −1·d−1) 或积极控制的药, fluoxetine (10 mg·为 3 个星期的 kg −1·d−1) 。行为的评价被执行每 week.Results : 在尖锐地分裂的老鼠海马趾的 CA1 神经原, YY-23 有选择地并且 reversibly 与 2.8 μ 的 EC 50 价值禁止了导致 NMDA 的水流; mol/L。由 YY-23 的导致 NMDA 的水流的这抑制是非竞争的,并且没有电压相关性或使用相关性的特征。有 YY-23 的强调老鼠的处理蔗糖偏爱和不动时间的不仅颠倒的导致厘米的缺乏,和社会相互作用的 导致CSDS 的减小,而且作为与 fluoxetine.Conclusion 相比有更快的发作: YY-23 是有在厘米和 CSDS 消沉的老鼠模型的有希望的快速的像抗抑郁剂的效果的 NMDA 受体的一个新奇非竞争的对手。 | QiZHANG Fei GUO Zhi-wen FU Bing ZHANG Cheng-gang HUANG Yang LI | 2016 | Acta Pharmacologica Sinica2016，37，2： | 6 |
| 5 | Effect of Sinai San decoction on the development of non-alcoholic steatohepatitis in rats显示文摘AIM: To explore the effect of Sinai san decoction on the development of non-alcoholic steatohepatitis induced by CCL4 combined with a fat-rich diet in rats.METHODS: Twenty-seven Sprague-Dawley rats were divided into three groups randomly: control group (n = 9),model group (n = 9) and treatment group (n = 9). The rats of model group and treatment group were given small dosage of CCL4 combined with a fat-rich diet, andthose of control group were given normal diet. After four weeks of fat-rich diet feeding, the rats of treatment group were given Sinai san decoction. The serum levels of aminotransferase and lipid were measured, and the pathology of livers was observed by HE staining after the rats were sacrificed at eight weeks.RESULTS: The rats' livers presented the pathology of steatosis and inflammation with higher serum levels of ALT and AST in the model group. In the treatment group the serum ALT and AST levels decreased significantly and were close to the control group. The hepatic inflammation scores also decreased markedly, but were still higher than those of control group. And the degree of hepatocyte steatosis was similar to that of model group.CONCLUSION: Sinai san decoction may ameliorate the hepatic inflammation of rats with steatohepatitis induced by small dosage of CCL4 combined with a fat-rich diet,but does not prevent the development of hepatocyte steatosis. | QiZhang YanZhao Deng-BenZhang Li-JunSun | 2005 | World Journal of Gastroenterology2005，11，9： | 6 |
| 6 | Study on S-shaped characteristic of Francis reversible unit by on-site test and CFD simulation显示文摘The operation parameters (vibration, shaft displacement and pressure fluctuation) of No. 1 Francis reversible unit of Baoquan pumped-storage power station were measured on site in the no-load mode at net heads of 518.04, 522.01 and 530.38 m, respectively. The rotational speed fluctuations in the no-load mode at three net heads were beyond synchronization requirement with obvious S-shaped characteristic, and misaligned guide vanes (MGV) had to be put into use for synchronization. Further analysis demonstrated that the rotating frequency signal was generally dominant in vibration and shaft displacement mixing signal in the no-load mode, while the frequency domain was wide without an obvious main frequency in pressure fluctuation mixing signal. Besides, the SST k-ω turbulence model was adopted to simulate the four quadrant characteristic curves of Baoquan model pump-turbine at three gate openings, and the relative error between simulation results and model test data was within ±6%, indicating that the simulation method in this paper is feasible and S-shaped characteristic of the pump-turbine can be simulated with CFD method. | LI JinWei HU QingJuan YU JiXing LI QiZhang | 2013 | Science China(Technological Sciences)2013，56，9： | 5 |
| 7 | An investigation of the effects of dust storms on rat lung using HRCT and blood gas analysis显示文摘The increasing intensity and frequency of sand-dust storms in China has led to greater prominence of associated environmental and health issues. Many studies have focused on the health effects of air particulate contaminants, but few formal investigations have studied the effects of sand-dust storms on human and animal health. The aim of this study was to investigate the effects of dust storms on rat lung by using high resolution computed tomography(HRCT) and blood gas analysis through a wind tunnel simulating. We found that the rat lung damage effects can be detected by the HRCT imaging after exposure to sand-dust storm environments, but had no obvious result through blood gas analysis. Exposure durations positively correlated with the damage degree to lung tissue. These will provide some evidence for clinical diagnosis of non-occupational pneumoconiosis. | FengFeng Lei WanYin Luo ZhiBao Dong YingZhu Sang LiZhu Luo Gang Huang Hua Liu QiZhang Chen | 2016 | Research in Cold and Arid Regions2016，8，4： | 5 |
| 8 | A new class of high-entropy M_(3)B_(4) borides显示文摘A new class of high-entropy M3B4 borides of the Ta_(3)B_(4)-prototyped orthorhombic structure has been synthesized in the bulk form for the first time.Specimens with compositions of(V0.2Cr0.2Nb0.2Mo0.2Ta0.2)3B4 and(V0.2Cr0.2Nb0.2Ta0.2W0.2)_(3)B_(4) were fabricated via reactive spark plasma sintering of high-energy-ball-milled elemental boron and metal precursors.The sintered specimens were〜98.7%in relative densities with virtually no oxide contamination,albeit the presence of minor(4-5 vol%)secondary high-entropy M5B6 phases.Despite that Mo_(3)B_(4) or W_(3)B_(4) are not stable phase,20%of M03B4 and W3B4 can be stabilized into the high-entropy M3B4 borides.Vickers hardness was measured to be 18.6 and 19.8 GPa at a standard load of 9.8 N.This work has further expanded the family of different structures of high-entropy ceramics reported to date. | Mingde QIN Qizhang YAN Yi LIU Jian LUO | 2021 | Journal of Advanced Ceramics2021，10，1： | 4 |
| 9 | LiPO_(2)F_(2) electrolyte additive for high-performance Li-rich cathode material显示文摘Li-rich layered oxide cathodes have received considerable attention because of the high operating potential and specific capacity. However, the structural instability and parasitic reactions at high potential cause severe degradation of the electrochemical performance. In our studies, the cycling stability of Li_(1.14)Ni_(0.133)Co_(0.133)Mn_(0.544)O_(2) cathode is improved with LiPO_(2)F_(2) electrolyte additive. After 500 cycles, the capacity retention is increased from 53.6% to 85% at 3 C by LiPO_(2)F_(2) modification. This performance is mainly attributed to the enhanced interfacial stability of the Li-rich cathode. Based on systematic characterization, LiPO_(2)F_(2) additive was found to promote a stable interface film on the cathode surface during the cycling and mitigates the interfacial side reactions. This study provides new insights for improving high-potential Li-rich layered oxide batteries. | Bing Jiang Jingru Li Bi Luo Qizhang Yan Hao Li Lehao Liu Lihua Chu Yingfeng Li Qiaobao Zhang Meicheng Li | 2021 | Journal of Energy Chemistry2021，30，9： | 3 |
| 10 | Effects of melatonin on wortmannin-induced tau hyperphosphorylation显示文摘Aim: To explore the underlying mechanism of tau hyperphosphorylation in an Alzheimer's-affected brain and the possible arresting strategies. Methods: MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide), crystal violet assay,phase-contrast, dead end colorimetric apoptosis detection system (TUNEL) and electron microscopy were used to detect cell viability, morphology and apoptosis.Western blot, ^32P-labeling and the detection of malondialdehyde level and superoxide dismutase activity were used respectively for the phosphorylation level of tau, the activity of glycogen synthase kinase (GSK-3), and oxidative stress measurement. Results: Exposure of the cells to wortmannin resulted in an obvious lipid peroxidation, reduction of cell viability, cell process retraction, and plasma vacuolation, but with no obvious cell apoptosis. We also found that preincubation of the cells with melatonin or vitamin E attenuated differentially wortmannininduced oxidative stress as well as GSK-3 overactivation and tau hyperphosphorylation. Conclusion: Wortmannin is an effective tool for reproducing Alzheimer-like tau hyperphosphorylation cell model and melatonin/vitamin E can effectively protect the cells from wortmannin-induced impairments. | Yan-qiuDENG Guo-gangXU PingDUAN QiZHANG Jian-zhiWANG | 2005 | Acta Pharmacologica Sinica2005，26，5： | 3 |
| 11 | Dynamic changes in fibrinogen levels of patients with acute cerebral infarction after taking defibrase显示文摘BACKGROUND: At present, as a therapeutic drug mainly for reducing fibrinogen (FIB) levels, the dynamic influence of defibrase on the FIB levels of patients with acute cerebral infarction has not been clearly ascertained. OBJECTIVE: To observe the dynamic changes in FIB levels of patients with acute cerebral infarction at different time points after taking defibrase. DESIGN, TIME AND SETTING: Randomized controlled clinical trial. The study was conducted in the Department of Neurology, the Second Affiliated Hospital of Jinan University, from June to November 2006. PARTICIPANTS: Sixty patients with acute cerebral infarction, who had been treated by the Neurological Department of the Second Affiliated Hospital of Jinan University from June to November 2006, were selected, including 37 males and 23 females, aged 35–75 years. All cases met the diagnostic criteria formulated by the Fourth National Cerebrovascular Disease Conference within 12 hours of onset. All the patients were confirmed with definite hemiparesis and cerebral infarction without coma, and were randomly divided into two groups: a treatment group (n =40) and a control group (n =20). Patients’ families had the right to be informed and agree with the treatment, which had permission from the Hospital Ethics Committee. METHODS: Patients in the control group were given routine treatment with 30 mL fleabane and 0.75 g cytidine diphosphate added to 500 mL saline solution once a day for 14 consecutive days. Patients in the treatment group were given routine treatment and Haiwang defibrase injection (purchased from Changchu Guoao Bio-Pharmaceutical Co. Ltd., Approval document number H10983237) within 12 hours of infarction. Defibrase doses of 15, 12.5 and 10 U were given over 2 hours according to the patients’ pre-treatment plasma FIB levels of ≥ 4.50 g/L, 3.50-4.49 g/L and 1.00-3.49 g/L, respectively. Plasma FIB levels in the treatment group were measured before, and once every six hours for 48 hours after administration of defibrase. Later, measurements were taken once every 12 hours and FIB levels were kept in a range of 0.5–1.3 g/L for one week. When the FIB level increased to over 1.3 g/L, a 5 U dose of defibrase was given again over two hours. FIB levels of the control group were measured once before treatment and once after one week of treatment MAIN OUTCOME MEASURES: (1) Dynamic changes of FIB levels in the defibrase treatment group. (2) Comparison of dynamic changes of FIB levels in the treatment group and control group before and after treatment for one week. RESULTS: All 60 patients were included in the final analysis. The treatment group’s FIB levels quickly decreased to 0.5–1.3 g/L within 12 hours of taking the first dose of defibrase and reached a minimum in 24 hours. Later, they began to rise slowly into the therapeutic range (0.5–1.3 g/L) in 48 hours. The FIB levels of the treatment group increased slowly to over 1.3 g/L in 60 hours after the first dose of defibrase and then quickly decreased to the therapeutic range after the second dose of 5 U defibrase with a minimum level higher than after the first dose, and higher again after the third dose. After treatment, patients’ FIB levels could be kept in the therapeutic range for about one week. The FIB levels in patients in the treatment group were significantly lower after taking defibrase for one week in comparison with the levels before treatment (P < 0.01). There was no difference in the control group between the levels pre-treatment and one week after treatment (P > 0.05). CONCLUSIONS: FIB levels in patients with acute cerebral infarction quickly decrease after taking the first dose of defibrase and reach a minimum in 24 hours. Later, they begin to rise slowly into the therapeutic range (0.5–1.3 g/L) in 48 hours. The FIB levels increase slowly to over 1.3 g/L in 60 hours. The effect of defibrase is weaker when the same dose of defibrase is used in patients repeatedly. | Yi Guo Ling Wang Bingshan Tang Fangming Li Qizhang Wang | 2008 | Neural Regeneration Research2008，3，5： | 3 |
| 12 | Geometry dependent photoconductivity of In2S3 kinks synthesized by kinetically controlled thermal deposition显示文摘在 2 S 3 性变态经由一个运动地控制的热免职过程被综合,他们的 optoelectronic 特征系统地被探索。生长机制被归因于联合运动动态,水晶美容精力,和表面粗糙。二个陷井劝诱了排放乐队经由低温度阴极射线发光(CL ) 被证实学习。而且, nanowire 连接证明作为与直手臂相比,退化 photodetection 表演归因于从 kinked 区域测量的一个导致压力的额外的系列电阻。无机的 nanostructures 和他们的 optoelectronic 性质的详细探索的井可控制的形状为他们的进一步实际的应用是特别地珍贵的。 | Xing Xiong QiZhang Lin Gan Xing Zhou Xiaonan Xing Huiqiao Li Tianyou Zhai | 2016 | Nano Research2016，9，12： | 2 |
| 13 | Conformal radiofrequency ablation of hepatocellular carcinoma with a multi‐pin bipolar system显示文摘 | Zhen‐WeiPeng Hui‐HongLiang Min‐ShanChen Yao‐JunZhang Ya‐QiZhang Wan Y.Lau | 2010 | J Surg Oncol2010，，1： | 1 |
| 14 | A matched case–control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma显示文摘 | ShijianLiu JiaxinXie JianhuaYin HongweiZhang QiZhang RuiPu ChengzhongLi WuNi HongyangWang GuangwenCao | 2010 | J. Med. Virol2010，，1： | 1 |
| 15 | Tupisteroide A–C, three new polyhydroxylated steroidal constituents from the roots of Tupistra chinensis显示文摘 | Cheng‐XiongLiu Zhi‐yongGuo Yan‐HongXue Hong‐YanZhang Hong‐QiZhang KunZou Nian‐YuHuang | 2012 | Magn Reson Chem2012，，4： | 1 |
| 16 | Association between plasma homocysteine levels and obstructive sleep apnoea in patients with ischaemic stroke显示文摘 | Maogang Chen Bona Wu Xinchun Ye Zhiming Zhou Xuanye Yue Qizhang Wang Wanxiang Wang Yongjun Jiang Xuegan Lian Zhaoyao Chen Gelin Xu Xinfeng Liu | 2011 | Journal of Clinical Neuroscience2011，，11： | 1 |
| 17 | Evaluation Method and Probabilistic Index of Voltage Sag Severity Considering Point-on-wave显示文摘The impact of voltage sag on sensitive devices is related to the time when the sag occurs.However,the point-on-wave of a sag is uncertain.Therefore,this paper presents a nov-el approach to evaluate the voltage sag severity considering a random point-on-wave.First,the uncertainty of equipment malfunction is revealed.Second,under a given residual voltage,the relationship between the point-on-wave and the duration that the device can withstand is described with a fitting curve.Third,a voltage sag probabilistic index is proposed to describe the severity.The evaluation procedure is also presented.Finally,three types of releasers are tested and analyzed to determine the effectiveness of the proposed method.The evaluation method can help instruct electrical engineers establish more well-grounded sag mitigation proposals. | Guopei Wu Qing Zhong Qizhang He Zhong Xu | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，3： | 1 |
| 18 | Evaluation of an antiparasitic compound extracted from Galla chinensis against fish parasite Ichthyophthirius multifiliis显示文摘 | Zhang Qizhang Xu De-Hai Klesius P H | 2013 | Vet Parasitol2013，198，12： | 1 |
| 19 | Surface modified long- life electrode for resistance spot welding显示文摘 | Zou Jiasheng Zhao Qizhang Chen Zheng | 2009 | Journal of Materials Processing Technology2009，209，8： | 1 |
| 20 | Stereotactic Aspiration Plus Subsequent Thrombolysis for Moderate Thalamic Hemorrhage显示文摘 | Maogang Chen Qizhang Wang Wusheng Zhu Qin Yin Minmin Ma Xinying Fan Yongkun Li Guanzhong Ni Chaolai Liu Wenhua Liu Renliang Zhang Gelin Xu Xinfeng Liu | 2012 | World Neurosurgery2012，，1： | 1 |
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