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| 1 | Neuroprotective effects of Buyang Huanwu decoction on cerebral ischemia-induced neuronal damage显示文摘Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi(Radix Astragali seu Hedysari), Danggui(Radix Angelica sinensis), Chishao(Radix Paeoniae Rubra), Chuanxiong(Rhizoma Ligustici Chuanxiong), Honghua(Flos Carthami), Taoren(Semen Persicae) and Dilong(Pheretima), and identifies the therapeutic targets and underlying mechanisms that contribute to the neuroprotective properties of Buyang Huanwu decoction. | Qingchun Mu Pengfei Liu Xitong Hu Haijun Gao Xu Zheng Haiyan Huang | 2014 | Neural Regeneration Research2014，9，17： | 32 |
| 2 | Velocity-Free MS/AE Source Location Method for Three-Dimensional Hole-Containing Structures显示文摘Microseismic/acoustic emission(MS/AE)source localization method is crucial for predicting and controlling of potentially dangerous sources of complex structures.However,the locating errors induced by both the irregular structure and pre-measured velocity are poorly understood in existing methods.To meet the high-accuracy locating requirements in complex three-dimensional hole-containing structures,a velocity-free MS/AE source location method is developed in this paper.It avoids manual repetitive training by using equidistant grid points to search the path,which introduces A*search algorithm and uses grid points to accommodate complex structures with irregular holes.It also takes advantage of the velocity-free source location method.To verify the validity of the proposed method,lead-breaking tests were performed on a cubic concrete test specimen with a size of 10 cm10 cm10 cm.It was cut out into a cylindrical empty space with a size of/6cm10 cm.Based on the arrivals,the classical Geiger method and the proposed method are used to locate lead-breaking sources.Results show that the locating error of the proposed method is 1.20 cm,which is less than 2.02 cm of the Geiger method.Hence,the proposed method can effectively locate sources in the complex three-dimensional structure with holes and achieve higher precision requirements. | Longjun Dong Qingchun Hu Xiaojie Tong Youfang Liu | 2020 | Engineering2020，6，7： | 22 |
| 3 | Adenovirus-mediated CTLA4Ig gene inhibits infiltration of immune cells and cell apoptosis in rats after liver transplantation显示文摘AIM: To investigate the role of adenovirus-mediated CTLA4Ig gene therapy in inhibiting the infiltration of macrophages and CD8+T cells and cell apoptosis after liver transplantation. METHODS: The rat orthotopic liver transplantation model was applied. The rats were divided into three groups: group I: rejection control (SD-to-Wistar); group Ⅱ: acute rejection treated with intramuscular injection of CsA 3.0 mg/(kg·d) for 12 d (SD-to-Wistar+CsA); groupⅢ: injection of 1×10^9 PFU adenovirus-mediated CTLA41g gene liquor in dorsal vein of penis 7 d before liver transplantation (SD-to-Wistar+CTLA4Ig). Immunohistochemistry and transferase-mediated dUTP nick-end labeling (TUNEL )were used to analyze the expression of CTLA4Ig gene in liver, infiltration of macrophages and CD8+T cells, cell apoptosis in grafts at different time-points after liver transplantation. Histopathological examination was done. RESULTS: CTLA4Ig gene expression was positive in liver on d 7 after administering adenovirus-mediated CTLA4Ig gene via vein, and remained positive until day 60 after liver transplantation. Infiltration of macrophages and CD8+T cells in CTLA4Ig-treated group was less than in rejection control group and CsA-treated group. The apoptotic index of rejection group on d 3, 5, and 7 were significantly higher than that of CTLA4Ig-treated group. A good correlation was found between severity of rejection reaction and infiltration of immune activator cells or cell apoptotic index in grafts. CONCLUSION: CTEA4Ig gene is constantly expressed in liver and plays an important role in inducing immune tolerance, | Guo-Ping Jiang, Zhen-Hua Hu, Shu-Sen Zheng, Chang-Ku Jia, Ai-Bin Zhang, Wei-Lin Wang, Department of Hepatobiliary Pancreatic Surgery, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China | 2005 | World Journal of Gastroenterology2005，11，7： | 14 |
| 4 | A NEW DAMAGE MECHANICS BASED APPROACH TO FATIGUE LIFE PREDICTION AND ITS ENGINEERING APPLICATION显示文摘An approach based on continuum damage mechanics to fatigue life prediction for structures is proposed. A new fatigue damage evolution equation is developed, in which the parameters are obtained in a simple way with reference to the experimental results of fatigue tests on standard specimens. With the utilization of APDL language on the ANSYS platform, a finite element implementation is presented to perform coupling operation on damage evolution of material and stress redistribution. The fatigue lives of some notched specimens and a Pitch-change-link are predicted by using the above approach. The calculated results are validated with experimental data. | Fei Shen Weiping Hu Qingchun Meng Miao Zhang | 2015 | Acta Mechanica Solida Sinica2015，28，5： | 4 |
| 5 | A DAMAGE MECHANICS MODEL FOR FATIGUE LIFE PREDICTION OF FIBER REINFORCED POLYMER COMPOSITE LAMINA显示文摘A damage mechanics fatigue life prediction model for the fiber reinforced polymer lamina is established. The stiffness matrix of the lamina is derived by elastic constants of fiber and matrix. Two independent damage degrees of fiber and matrix are introduced to establish constitutive relations with damage. The damage driving forces and damage evolution equations for fiber and matrix are derived respectively. Fatigue tests on 0°and 90°unidirectional laminates are conducted respectively to identify parameters in damage evolution equations of fiber and matrix. The failure criterion of the lamina is presented. Finally, the life prediction model for lamina is proposed. | Wenjing Shi Weiping Hu Miao Zhang Qingchun Meng | 2011 | Acta Mechanica Solida Sinica2011，24，5： | 4 |
| 6 | A Landscape Pattern Analysis Method Based on Boundaries and Nodes:A Case Study in Upper Minjiang River,China显示文摘Traditionally,patch-based analysis at the landscape scale fragmentation has been used in the study of landscape ecology while the study of boundary and node has not been considered as much detail until recently.This study investigated the possibility of applying boundary-and node-based methods in landscape pattern analysis to the upper reaches of the Minjiang River in the southwestern China.Boundary-based and node-based landscape indices were selected to be used in analyzing changes in landscape patterns,and the results were compared with analysis using traditional pattern indices.We compared the responses of patch-area-based,boundary-length-based and node-number-based indices,and concluded that boundary-based and node-based indices are more sensitive to disturbance than patch-based indices with various patterns,and node-based indices are even more sensitive than boundary-based ones.Thus,the results suggest that boundary-based and node-based pattern analysis methods provide helpful supplementary information to traditional patch-based pattern analysis methods.The results about pattern dynamics of landscapes in the upper reaches of the Minjiang River based on boundaries and nodes showed that with human disturbance,the dominance of forest landscape was weakened by other landscape types;thus the landscape pattern of the study area became more homogeneous and the boundary network became more complex.These changes further augmented disturbance interfaces in the landscape and increased the possibilities of further landscape fragmentation. | WEN Qingchun LI Xiuzhen HE Hongshi HU Yuanman CHEN Xin CHANG Yu WANG Wei BU Rencang | 2014 | Chinese Geographical Science2014，24，1： | 3 |
| 7 | Development of high-resolution chloroplast markers for intraspecific phylogeographic studies of Phaeocystis globosa显示文摘Phaeocystis globosa is an important harmful algal bloom causative species distributing widely in temperate and tropical coastal waters in the world.The morphological,physiological,and biochemical characteristics are different among geographic strains,which can not be distinguished with nuclear ribosomal DNA markers at present.Therefore,the genetic distance and phylogeographic relationships of nuclear 28S rDNA D1–D2 and ITS regions,and three chloroplast intergenic spacers(petN-trnS1,trnM1-psbA,and rbcS-rpl27)were analyzed and compared among 13 strains of P.globosa isolated from the Pacific Ocean and Atlantic Ocean in this study.In addition,the nucleotide polymorphisms of 28S rDNA D1–D2,ITS,and rbcS-rpl27 regions were evaluated in two P.globosa strains.The various levels of nucleotide polymorphism were in the nuclear 28S rDNA D1–D2 region and ITS region,but no polymorphism was in the chloroplast rbcS-rpl27 intergenic spacer.A reasonable intraspecific phylogeographic relationship was presented by rbcS-rpl27 intergenic spacer,which had the strongest distinction to geographic strains compared to those of 28S rDNA D1–D2 and ITS regions.In the phylogenetic tree of rbcS-rpl27 intergenic spacer,the two strains from the North Sea of the Atlantic Ocean were divided firstly from the species of P.globosa,and then formed an independent clade,while the other Atlantic strains and all of Pacific strains joined up to build the other clade.It was implied that at least two genetically distant populations of P.globosa existed in the Atlantic coastal regions.This study provided a high-resolution chloroplast marker to analyze intraspecific phylogeographic populations of P.globosa,and preliminarily clarified the genetic relationships of the Pacific and Atlantic strains of P.globosa. | Qingchun ZHANG Zhuang NIU Jinxiu WANG Chao LIU Fanzhou KONG Xiaokun HU Jiayu ZHAO Rencheng YU | 2021 | Journal of Oceanology and Limnology2021，39，2： | 3 |
| 8 | Revised damage evolution equation for high cycle fatigue life prediction of aluminum alloy LC4 under uniaxial loading显示文摘The fatigue life prediction for components is a difficult task since many factors can affect the final fatigue life. Based on the damage evolution equation of Lemaitre and Desmorat, a revised two-scale damage evolution equation for high cycle fatigue is presented according to the experimental data, in which factors such as the stress amplitude and mean stress are taken into account. Then, a method is proposed to obtain the material parameters of the revised equation from the present fatigue experimental data.Finally, with the utilization of the ANSYS parametric design language(APDL) on the ANSYS platform, the coupling effect between the fatigue damage of materials and the stress distribution in structures is taken into account, and the fatigue life of specimens is predicted. The outcome shows that the numerical prediction is in accord with the experimental results, indicating that the revised two-scale damage evolution model can be well applied for the high cycle fatigue life prediction under uniaxial loading. | Zhixin ZHAN Weiping HU Miao ZHANG Qingchun MENG | 2015 | Applied Mathematics and Mechanics(English Edition)2015，36，9： | 3 |
| 9 | Tension-Torsion High-Cycle Fatigue Life Prediction of 2A12-T4 Aluminium Alloy by Considering the Anisotropic Damage:Model, Parameter Identification, and Numerical Implementation显示文摘To consider the anisotropic damage in fatigue, an improved boom-panel model is presented to simulate a representative volume element(RVE) in the framework of continuum damage mechanics. The anisotropic damage state of the RVE is described by the continuity extents of booms and panels, whose damage evolutions are assumed to be isotropic. The numerical implementation is proposed on the basis of damage mechanics and the finite element method. Finally,the approach is applied to the fatigue life prediction of 2A12-T4 aluminium alloy specimen under cyclic loading of tension-torsion. The results indicate a good agreement with the experimental data. | Linlin Sun Miao Zhang Weiping Hu Qingchun Meng | 2016 | Acta Mechanica Solida Sinica2016，29，4： | 2 |
| 10 | REACTION MODEL IN Al-Ti-C SYSTEM显示文摘REACTIONMODELINAl-Ti-CSYSTEM￥WANGZidong;HUHanqi(UniversityofScienceandTechnologyBeijing.Beijing,China)LiQingchun(Harbininstit... | WANG Zidong HU Hanqi(University of Science and Technology Beijing.Beijing,China)Li Qingchun(Harbin institute of Technology,Harbin.China | 1995 | Acta Metallurgica Sinica(English Letters)1995，8，2： | 2 |
| 11 | Acoustic emission source location method and experimental verification for structures containing unknown empty areas显示文摘Acoustic emission(AE)localization plays an important role in the prediction and control of potential hazardous sources in complex structures.However,existing location methods have less discussion on the presence of unknown empty areas.This paper proposes an AE source location method for structures containing unknown empty areas(SUEA).Firstly,this method identifies the shape,size,and location of empty areas in the unknown region by exciting the active AE sources and using the collected AE arrivals.Then,the unknown AE source can be located considering the identified empty areas.The lead break experiments were performed to verify the effectiveness and accuracy of the proposed method.Five specimens were selected containing empty areas with different positions,shapes,and sizes.Results show the average location accuracy of the SUEA increased by 78%compared to the results of the existing method.It can provide a more accurate solution for locating AE sources in complex structures containing unknown empty areas such as tunnels,bridges,railroads,and caves in practical engineering. | Longjun Dong Qing Tao Qingchun Hu Sijia Deng Yongchao Chen Qiaomu Luo Xihong Zhang | 2022 | International Journal of Mining Science and Technology2022，32，3： | 2 |
| 12 | New approach based on continuum damage mechanics with simple parameter identification to fretting fatigue life prediction显示文摘A new continuum damage mechanics model for fretting fatigue life prediction is established. In this model, the damage evolution rate is described by two kinds of quantities. One is associated with the cyclic stress characteristics obtained by the finite element(FE) analysis, and the other is associated with the material fatigue property identified from the fatigue test data of standard specimens. The wear is modeled by the energy wear law to simulate the contact geometry evolution. A two-dimensional(2D)plane strain FE implementation of the damage mechanics model and the energy wear model is presented in the platform of ABAQUS to simulate the evolutions of the fatigue damage and the wear scar. The effect of the specimen thickness is also investigated.The predicted results of the crack initiation site and the fretting fatigue life agree well with available experimental data. Comparisons are made with the critical plane SmithWatson-Topper(SWT) method. | Fei SHEN Weiping HU Qingchun MENG | 2015 | Applied Mathematics and Mechanics(English Edition)2015，36，12： | 2 |
| 13 | Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients显示文摘 | Dekai Qiu Qixia Wang Hui Wang Qing Xie Guoqing Zang Hong Jiang Chuantao Tu Jinsheng Guo Shuncai Zhang Jianshe Wang Yi Lu Ying Han Lei Shen Xiaoyu Chen Xiqi Hu Xiaojin Wang Chengwei Chen Qingchun Fu Xiong Ma | 2010 | Journal of Hepatology2010，，： | 2 |
| 14 | Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-lH-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents显示文摘 | ZHANG Lan DENG Xinshan WU Jiaofeng MENG Guangpeng LIU Congchong CHEN Guzhou ZHAO Qingchun HU Chun | 2017 | Chemical Research in Chinese Universities2017，33，3： | 1 |
| 15 | Experimental method for and theoretical research on defect tolerance of fxed plate based on damage mechanics显示文摘An experimental method and a theoretical analysis based on continuum damage mechanics are applied for the defects tolerance of fxed plate.The defects type studied in this article is scratch,which is considered a typical defect on fxed plate according to the engineering practice.The general approach to the defects tolerance analysis of scratched fxed plate is presented.The method of fatigue life prediction for standard notched specimens has been established on the basis of continuum damage mechanics.For the purpose of obtaining the influence law of fatigue life in consequence of scratches,fatigue experiments of standard notched specimens and scratched specimens have been done.Evaluation of the fatigue life of scratched fxed plate has been carried out.And the value of scratch defects permissible to the condition of safety service life has been worked out.According to the results of theoretical calculations,the fatigue experiment of scratched fxed plate has been performed.The outcome shows that the theoretical prediction tallies with the experimental results. | Zhan Zhixin Hu Weiping Zhang Miao Zhu Yuefa Meng Qingchun | 2013 | Chinese Journal of Aeronautics2013，26，5： | 1 |
| 16 | Ignition Characteristics of a Liquid-Kerosene-Fueled Scramjet during Air Throttling Combined with a Gas Generator显示文摘 | Wen Bao Jichao Hu Youhai Zong Qingchun Yang Juntao Chang Meng Wu Daren Yu | 2013 | Journal of Aerospace Engineering2013，，： | 1 |
| 17 | An electrochemical investigation of the diethyldithiocarbamate-galena flotation system 显示文摘 | Hu Qingchun Wang Dianzhuo Li Bodan | 1992 | International Journal of Mineral Processing1992，34，： | 1 |
| 18 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 19 | Energy approach to a linearization contact problem of simply supported cross-ply laminated composite plate显示文摘 | Hu Weiping Zhang Xing Meng Qingchun | 2002 | International Journal of Solids and Structures2002，39，： | 1 |
| 20 | A 10<ce:hsp sp='0.16'/>kW class PEM fuel cell stack based on the catalyst-coated membrane (CCM) method显示文摘 | Mingruo Hu Sheng Sui Xinjian Zhu Qingchun Yu Guangyi Cao Xueying Hong Hengyong Tu | 2006 | International Journal of Hydrogen Energy2006，，8： | 1 |
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