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| 1 | EGCG attenuates pro-inflammatory cytokines and chemokines production in LPS-stimulated L02 hepatocyte显示文摘内毒素 lipopolysaccharide (LPS ) 作为第二攻击在肝炎的煽动性的反应的加速起一个重要作用。能由指向 LPS 阻止发炎的混合物有潜在的治疗学的临床的申请。Epigallocatechin-3-gallate (EGCG ) 有有势力 hepatocyte 保护的效果和温和反肝炎病毒工作。这里,我们调查了 EGCG 是否在刺激 LPS 的 L02 hepatocytes 稀释了煽动性的反应的严厉。L02 hepatocytes 是有为 2 h 的 EGCG 的 pretreated,然后在 250 ng/ml 由 LPS 刺激了。 chemokine 的表示层次在表示并且藏匿的激活正常T房间( Rantes )和单核白血球之上调整了趋化性的 protein-1 ( MCP-1 ), 支持inflammatory cytokines 肿瘤坏死因素--(TNF-)并且干扰素--,粘附分子细胞间的粘附 molecule-1 ( ICAM-1 ),氧化剂压力分子氮的氧化物(没有),脉管的 endothelial 生长因素( VEGF ),和矩阵 metalloproteinase-2 ( MMP-2 )被连接酶的 immunosorbent 试金测试。全部的细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 的表示, phospho-ERK1/2 (p-ERK1/2 ) , p-AKT,全部的 p38, phospho-p38 (p-p38 ) ,全部的 p65 和 phospho-p65 (p-p65 ) , IB, phospho-IB (p-IB ) 和 TNF 受体联系了因素 2 被西方的污点分析测试。我们的结果证明有 EGCG 的那个预告的处理能显著地减少 TNF- 的生产, Rantes, MCP-1, ICAM-1,不在以一种剂量依赖者方式的刺激 LPS 的 L02 hepatocytes 的 VEGF,和 MMP-2。EGCG 的效果可能与原子 factor-B (NF-B ) 和由 p-IB, p65, p-p65, p-p38, p-ERK1/2,和 p-AKT 的下面规定表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 EGCG 压制导致 LPS 的煽动性的反应和氧化剂应力并且由禁止 NF-B 和 MAPK 小径部分施加它的 hepatocyte 保护的活动。 | Qiaoli Liu Yun Qian Feng Chen Xiaoming Chen Zhi Chen Min Zhen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 11 |
| 2 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 3 | Detection of geosmin and 2-methylisoborneol by liquid-liquid extraction-gas chromatograph mass spectrum (LLE-GCMS) and solid phase extraction-gas chromatograph mass spectrum (SPE-GCMS)显示文摘Two sample preparation methods were introduced and compared in this paper to establish a simple,quick and exact analysis of geosmin and 2-methylisoborneol.LC-18 column was employed in solid phase extraction(SPE),1.0 mL of hexane was adopted in liquid-liquid extraction(LLE),and the extracts were analyzed by gas chromatograph mass spectrum(GCMS)in selected ion mode.Mean recoveries of SPE were low for 2-methylisoborneol(2-MIB)and geosmin(GSM)with values below 50%.For LLE,the recoveries were satisfyingly above 50%for 2-MIB and 80%for GSM.Detection limits of the LLE method were as low as 1.0 ng/L for GSM and 5.0 ng/L for 2-MIB.A year-long investigation on odor chemicals of drinking water in Shanghai demonstrated that in the summer,there was a serious odor problem induced by a high concentration of 2-MIB.The highest concentration of 152.82 ng/L appeared in July in raw water,while GSM flocculation was minimal with concentrations below odor threshold. | MA Xiaoyan GAO Naiyun CHEN Beibei LI Qingsong ZHANG Qiaoli GU Guofen | 2007 | Frontiers of Environmental Science & Engineering2007，1，3： | 7 |
| 4 | Novel hydrogen storage properties of palladium nanocrystals activated by a pentagonal cyclic twinned structure显示文摘研究人员们看起来忽视了雏晶的一种特殊形式,五角的周期的 twinning,明显的二维的格子扩大在存在导致新奇 physicalchemical 性质在几何、电子的结构与变化联系了。在 Pd nanocrystals 把氢的存储和版本用作一根探针,我们发现了五角的周期的孪生的 Pd nanocrystals 有的那 icosahedral 不同的氢存储性质由于二维的格子扩大,与那些相当不同八面的单个水晶的对应物。另外,在五角的周期的孪生的 Pd nanocrystals 的二维的格子扩大在电子结构引起一个变化,它导致在 PdH x 五角的周期的孪生的 nanocrystals。 | Huang Huang Shixiong Bao Qiaoli Chen Yanan Yang Zhiyuan Jiang Qin Kuang Xiaoyin Wu Zhaoxiong Xie Lansun Zheng | 2015 | Nano Research2015，8，8： | 7 |
| 5 | A facile surfactant-free synthesis of Rh flower-like nanostructures constructed from ultrathin nanosheets and their enhanced catalytic properties显示文摘Rh 是广泛地在许多器官的反应被使用的重要催化剂。在最近的年里,许多努力集中了于由与控制尺寸和形态学制作催化剂 nanoparticles 改进它的催化效率。然而,也把有机化合物用作反应媒介或盖住代理人的经常采用的合成线路经常在催化剂表面上导致剩余分子,它急速地接着减少催化表演。此处,我们报导甲醛经由 Rh (acac )3 的热水的减小获得的新奇 Rh 象花的结构的灵巧的、水的、没有表面活化剂的合成。唯一的 Rh nanoflowers 从 ultrathin nanosheets 被构造,其基础表面包括了 { 111 } 有 ~ 的平均厚度的方面 1.1 nm。特定的表面区域由公司脱衣测量了 79.3 是 m 2 钟声到 134.4 食火鸟的浸透的磁化 ???? 愠汬祯湩吗?? | Yaqi Jiang Jingyun Su Yanan Yang Yanyan Jia Qiaoli Chen Zhaoxiong Xie Lansun Zheng | 2016 | Nano Research2016，9，3： | 7 |
| 6 | Effectiveness of Traditional Chinese Medicine (TCM) treatments on the cognitive functioning of elderly persons with mild cognitive impairment associated with white matter lesions显示文摘 | Songming HE Lijun LI Juying HU Qiaoli CHEN Weiqun SHU | 2015 | 上海精神医学2015，27，5： | 7 |
| 7 | Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway显示文摘The stiffness of the extracellular matrix(ECM)plays an important role in regulating the cellular programming.However,the mechanical characteristics of ECM affecting cell differentiation are still under investigated.Herein,we aimed to study the effect of ECM substrate stiffness on macrophage polarization.We prepared polyacrylamide hydrogels with different substrate stiffness,respectively.After the hydrogels were confirmed to have a good biocompatibility,the bone marrow-derived macrophages(BMMs)from mice were incubated on the hydrogels.With simulated by the low substrate stiffness,BMMs displayed an enhanced expression of CD86 on the cell surface and production of reactive oxygen species(ROS)in cells,and secreted more IL-1βand TNF-αin the supernatant.On the contrary,stressed by the medium stiffness,BMMs expressed more CD206,produced less ROS,and secreted more IL-4 and TGF-β.In vivo study by delivered the hydrogels subcutaneously in mice,more CD68+CD86+cells around the hydrogels with the low substrate stiffness were observed while more CD68+CD206+cells near by the middle stiffness hydrogels.In addition,the expressions of NIK,phosphorylated p65(pi-p65)and phosphorylated IκB(pi-IκB)were significantly increased after stimulation with low stiffness in BMMs.Taken together,these findings demonstrated that substrate stiffness could affect macrophages polarization.Low substrate stiffness promoted BMMs to shift to classically activated macrophages(M1)and the middle one to alternatively activated macrophages(M2),through modulating ROS-initiated NF-κB pathway.Therefore,we anticipated ECM-based substrate stiffness with immune modulation would be under consideration in the clinical applications if necessary. | Mimi Chen Yu Zhang Pinghui Zhou Xingzhi Liu Huan Zhao Xichao Zhou Qiaoli Gu Bin Li Xuesong Zhu Qin Shi | 2020 | Bioactive Materials2020，5，4： | 7 |
| 8 | Identification of QTL and candidate genes involved in early seedling growth in rice via high-density genetic mapping and RNA-seq显示文摘Early seedling vigor(ESV)is a major breeding target in rice,especially under direct seeding.To identify quantitative trait locus(QTL)affecting ESV,a recombinant inbred line population derived from a cross between 02428 and YZX,two cultivars differing in vigor during early seedling growth,was used for QTL analysis.Nine traits associated with ESV were examined using a high-density map.Of 16 additive loci identified,three were detected in two generations and thus considered stable.Four epistatic interactions were detected,one of which was repeated in two generations.Further analysis of the pyramiding effect of the three stable QTL showed that the phenotypic value could be effectively improved with an increasing number of QTL.These results were combined with results from our previous QTL analysis of the germination index.The lines G58 and G182 combined all the favourable alleles of all three stable QTL for ESV and three QTL for germination speed.These two lines showed rapid germination and strong ESV.A total of 37 candidate differentially expressed genes were obtained from the regions of the three stable QTL by analysis of the dynamic transcriptomic expression profile during the seedling growth period of the two parents.The QTL are targets for ESV breeding and the candidate genes await functional validation.This study provides a theoretical basis and a genetic resource for the breeding of directseeded rice. | Jing Yang Zhenhua Guo Lixin Luo Qiaoli Gao Wuming Xiao Jiafeng Wang Hui Wang Zhiqiang Chen Tao Guo | 2021 | The Crop Journal2021，9，2： | 6 |
| 9 | Effect of Er-Xian decoction(二仙汤) on autoimmune premature ovarian failure in mice显示文摘OBJECTIVE:To investigate the therapeutic effect of Er-Xian decoction(二仙汤,EXD)on the autoimmune premature ovarian failure(POF)in mice,and its regulatory mechanisms.METHODS:Female BALB mice were treated with a single intraperitoneal injection of zona pellucida 3(ZP3).One week later,mice received low(5 g/kg),moderate(10 g/kg)and high(20 g/kg)doses of EXD by gastrogavage once daily for 90 d.Premarin(0.03 mg/kg)served as the positive control group.Serum levels of estradiol(E2),follicle stimulating hormone(FSH)and luteinizing hormone(LH)were measured by enzyme-linked immunosorbent assay,lymphocyte subtypes were analyzed,and follicular structure differences were observed by hematoxylin andeosin staining.The main mechanisms of POF was investigated by immunohistochemical analysis.RESULTS:Serum E2 levels in POF model mice were decreased,whereas FSH and LH levels were dramatically increased.Serum levels of LH and FSH were reduced in POF model mice treated with EXD(moderate and high doses)and premarin,while serum level of E2 were increased after POF model mice had been treated with EXD and premarin.The CD3+T,CD4+T,CD4+T/CD8+T ratio of mice in the positive control group and high and medium dose groups of EXD increased(P<0.05),and the number of CD8+T cells decreased significantly(P<0.05)when compared with the model group.Bone morphogenetic protein 15(BMP15)and Akt were repressed in autoimmune POF model mice,whereas high expression was observed in control mice and those treated with EXD(moderate and high doses)and premarin.CONCLUSION:EXD is effective in treating ZP3-induced POF in mice and increased expression of BMP-15,and Akt is represented in the mechanism accounting for this therapeutic effect. | ZHANG Xiaoli LI Jing ZHOU Xiaolin CHEN Qiaoli | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 6 |
| 10 | All-fiber passively mode-locked laser using nonlinear multimode interference of step-index multimode fiber显示文摘We experimentally demonstrate for the first time, to the best of our knowledge, an all-fiber passively mode-locked laser operation based on the nonlinear multimode interference of step-index multimode fiber. Such a structure couples the light in and out of the multimode fiber via single-mode fibers, and its physical mechanisms for saturable absorption have been analyzed theoretically based on the third-order nonlinear Kerr effect of multimode fiber. Using the nonlinear multimode interference structure with 48.8 mm length step-index multimode fiber, the modulation depth has been measured to be ~5%. The passively mode-locked laser output pulses have a central wavelength of 1596.66 nm, bandwidth of 2.18 nm, pulsewidth of ~625 fs, and fundamental repetition rate of8.726 MHz. Furthermore, the influence of total cavity dispersion on the optical spectrum, pulse width, and output power is investigated systematically by adding different lengths of single-mode fiber and dispersion compensation fiber in the laser cavity. | TAO CHEN QIAOLI ZHANG YAPING ZHANG XIN LI HAIKUN ZHANG WEI XIA | 2018 | Photonics Research2018，，11： | 4 |
| 11 | 18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs显示文摘Hepatic stellate cells(HSCs)are essential drivers of fibrogenesis.Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis.18beta-glycyrrhetinic acid(18b-GA)is a natural compound that exists widely in herbal medicines,such as Glycyrrhiza uralensis Fisch,which is used for treating multiple liver diseases,especially in Asia.In the present study,we demonstrated that 18b-GA decreased hepatic fibrosis by inducing the apoptosis in activated HSCs.18b-GA inhibited the expression of a-smooth muscle actin and collagen type Ⅰ alpha-1.Using a chemoproteomic approach derived from activity-based protein profiling,together with cellular thermal shift assay and surface plasmon resonance,we found that 18b-GA covalently targeted peroxiredoxin 1(PRDX1)and peroxiredoxin 2(PRDX2)proteins via binding to active cysteine residues and thereby inhibited their enzymatic activities.18b-GA induced the elevation of reactive oxygen species(ROS),resulting in the apoptosis of activated HSCs.PRDX1 knockdown also led to ROS-mediated apoptosis in activated HSCs.Collectively,our findings revealed the target proteins and molecular mechanisms of 18b-GA in ameliorating hepatic fibrosis,highlighting the future development of 18b-GA as a novel therapeutic drug for hepatic fibrosis. | Qian Zhang Piao Luo Liuhai Zheng Jiayun Chen Junzhe Zhang Huan Tang Dandan Liu Xueling He Qiaoli Shi Liwei Gu Jiahao Li Qiuyan Guo Chuanbin Yang Yin Kwan Wong Fei Xia Jigang Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 3 |
| 12 | Surfactant dependent evolution of Au-Pd alloy nanocrystals from trisoctahedron to excavated rhombic dodecahedron and multipod: a matter of crystal growth kinetics显示文摘In wet chemical syntheses of noble metal nanocrystals,surfactants play crucial roles in regulating their morphology.To date,more attention has been paid to the effect of the surfactant on the surface energy of crystal facets,while less attention has been paid to its effect on the growth kinetics.In this paper,using the growth of Au-Pd alloy nanocrystals as an example,we demonstrate that different concentration of surfactant hexadecyltrimethyl ammonium chloride(CTAC)may cause the different packing density of CTA+bilayers on different sites(face,edge or vertex)of crystallite surface,which would change the crystal growth kinetics and result in preferential crystal growth along the edge or vertex of crystallites.The unique shape evolution from trisoctahedron to excavated rhombic dodecahedron and multipod structure for Au-Pd alloy nanocrystals was successfully achieved by simply adjusting the concentration of CTAC.These results help to understand the effect of surfactants on the shape evolution of nanocrystals and open up avenues to the rational synthesis of nanocrystals with the thermodynamically unfavorable morphologies. | Qiaoli Chen Guifen Du Yongdi Dong Zhenming Cao Zhaoxiong Xie Lansun Zheng | 2017 | Science Bulletin2017，62，20： | 2 |
| 13 | Relationship between corneal biomechanical parameters and corneal sublayer thickness measured by Corvis ST and UHR-OCT in keratoconus and normal eyes显示文摘Background:To explore the relationship between corneal biomechanical parameters and corneal sublayer thickness using corneal visualization Scheimpflug technology(Corvis ST)and ultrahigh-resolution optical coherence tomography(UHR-OCT)in clinical and suspected keratoconus and normal eyes.Methods:Cross-sectional prospective study.A total of 94 eyes of 70 participants were recruited.Twenty five eyes of 19 keratoconus patients,52 eyes of 34 patients showing high risk of developing keratoconus according to the Belin/Ambrosio Enhanced Ectasia Display,and each eye of 17 normal subjects were enrolled.All participants underwent Corvis ST,Pentacam,and UHR-OCT examinations at the same time.Stiffness parameter A1(SP-A1),deformation amplitude ratio(DA ratio),and other biomechanical parameters were recorded using Corvis ST.The vertical and horizontal thickness profiles of central 3mm corneal epithelium,Bowman’s layer,and stroma as measured by the perpendicular distance between the neighboring interfaces were generated using UHR-OCT.The flat keratometry and steep keratometry were obtained using Pentacam.Analysis of correlation was applied to explore the association between variables.Results:Most of the biomechanical parameters and corneal sublayer thickness profiles showed statistical differences among three groups.A statistically significant linear relationship was noted between SP-A1 and DA ratio in all three groups.SP-A1 was found to be positively correlated with epithelial and Bowman’s layer thickness in the keratoconus(KC)group,and with stromal thickness in all three groups.In the normal and suspected keratoconus(SKC)groups,only stromal thickness was included in the stepwise linear regression to predict SP-A1,whereas in the KC group,steep keratometry and Bowman’s layer thickness were included.Conclusions:Significant and different correlations were noted between corneal stiffness and corneal sublayer thickness in different groups,indicating that corneal sublayers may play different roles in maintaining corneal biomechanical stability between keratoconus and normal eyes. | Yong Li Zhiqiang Xu Qiaoli Liu Yuzhou Wang Kan Lin Jiahui Xia Shihao Chen Liang Hu | 2021 | Eye and Vision2021，8，1： | 2 |
| 14 | Novel sol-gel material for fabrication of a long period waveguide grating filter as a precise thermometer显示文摘A new kind of organic-inorganic hybrid HfO 2/SiO 2 sol-gel material with a large thermo-optic coefficient and a wide linear tunable temperature range has been developed for fabrication of a long period waveguide grating (LPWG) filter,whose parameters were optimized and designed by using finite difference time domain (FDTD) simulations.The LPWG filter,a periodic rectangle-corrugated grating structure,was easily fabricated with soft-lithography technique.At a temperature range from 19°C to 70°C,the fabricated LPWG filter element demonstrated a high temperature sensitivity of about 6.5 nm/°C and a wide linear tunable temperature range of 51°C,so that it can be used as a precise thermometer.Our results are useful for the designs of LPWG filters for the implementation of a wide range of thermo-optic functions. | WANG Xin LI XiaoChan ZHANG Tao HU CanDong ZHU QiuXiang CHEN SiHai LI Yun XU Jia HE Miao NIU QiaoLi ZHAO LingZhi LI ShuTi ZHANG Yong | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 2 |
| 15 | miR-101-3p induces vascular endothelial cell dysfunction by targeting tet methylcytosine dioxygenase 2显示文摘Endothelial cell(EC)dysfunction represents an early key event in atherosclerosis.Recently,MicroRNAs have been demonstrated to regulate EC function.miR-101-3p has been discovered to regulate cell apoptosis and proliferation in cardiovascular diseases.Therefore,the aim of the current study was to clarify whether miR-101-3p regulates the dysfunction of vascular endothelial cells.In this study,the transfection of human umbilical vein endothelial cells(HUVECs)with miR-101-3p mimic induced reactive oxygen species(ROS)production,EC dysfunction,and acti-vated nuclear factorB(NF-κB),whereas transfection with miR-101-3p inhibitor alleviated these events.The antioxidant N-acetylcysteine alleviated miR-101-3p-induced EC dysfunction.Moreover,we observed that miR-101-3p inhibited the expression of tet methylcytosine dioxygenase 2(TET2)at the posttranscriptional level,resulting in increased ROS production and activated NF-kB.TET2 overexpression inhibited ROS production,EC dysfunction,and NF-κB activation in miR-101-3p-transfected HUVECs.These results indicate that miR-101-3p induces EC dysfunction by targeting TET2,which regulates ROS production,EC dysfunction,and NF-κB activation.Taken together,our current study reveals a novel pathway associated with EC dysfunction.The modulation of miR-101-3p and TET2 expression levels may serve as a potential target for therapeutic strategies for atherosclerosis. | Qiaoli Chen Xiaoye Li Lingjun Kong Qing Xu Zi Wang Qianzhou Lv | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 2 |
| 16 | Polar codes: Encoding/decoding and rate-compatible jointly design for HARQ system显示文摘Polar coding are the first class of provable capacity-achieving coding techniques for a wide range of channels.With an ideal recursive structure and many elegant mathematical properties,polar codes are inherently implemented with low complexity encoding and decoding algorithms.Since the block length of the original polar construction is limited to powers of two,rate-compatible polar codes(RCPC)are presented to meet the flexible length/rate transmission requirements in practice.The RCPC codes are well-conditioned to combine with the hybrid automatic repeat request(HARQ)system,providing high throughput efficiency and such RCPC-HAPQ scheme is commonly used in delay-insensitive communication system.This paper first gives a survey of both the classical and state-of-the-art encoding/decoding algorithms for polar codes.Then the RCPC construction methods are discussed,including the puncturing,shortening,multi-kernel construction,etc.Finally,we investigate several RCPC-HARQ jointly design systems and discuss their encoding gain and re-transmission diversity gain. | Qiaoli Zeng Quan Zhou Xiangkun He Youming Sun Xiangcheng Li Haiqiang Chen | 2021 | Intelligent and Converged Networks2021，2，4： | 1 |
| 17 | DBT parameters and dynamic monitoring during reservoir development, and distribution region prediction of remaining oil:A case study on the Sha-3~3 oil reservoir in the Liubei region, Nanpu sag显示文摘In this study, compositional characteristics of crude oil, including the variation of aliphatic, aromatic and pyrrolic nitrogen compounds, were systematically monitored and investigated in a high water-cut oil reservoir over a short time.The results showed that among the widely used parameters indicative of oil maturity and migration, tetramethyl/monomethyl DBT and tricyclic terpane/(tricyclic terpane+C30 hopanoid) varied remarkably, and a positive correlation was observed between these two parameters.The variation of each of these parameters during waterflooding development was correlated with the flow effect of crude promoted by the water drive in oil reservoirs.A solid consistency was observed among the results of numerical simulation and development; the direction and pathway of waterflooding crude was indicated by Tetramethyl/monomethyl DBT, and the distribution region prediction of remaining oil hereby obtained.Therefore, these two parameters could be used as molecular tracers for the oil during waterflooding.This study would be of practical significance for geochemical dynamic monitoring and reservoir development. | XU YaoHui WANG TieGuan CHEN NengXue YANG CuiMin WANG QiaoLi | 2012 | Science China Earth Sciences2012，55，12： | 1 |
| 18 | CONTROLLED HOT FORMING OF RETAINING RING OF GENERATOR显示文摘0INTRODUCTIONMostoftheretainingringsofgeneratorarecurentlymadeofthesteelof50Mn18Cr4orMn18Cr18N.Itbecomesadificultyinthemanufa... | Zhang Qiaoli Chen Huiqin Guo Huiguang Taiyuan Heavy Machinery Institute Guo Yajun Taiyuan Orient Three Stars New Technology Co. Ltd. | 1999 | Chinese Journal of Mechanical Engineering1999，12，2： | 1 |
| 19 | Low rate of pre-exposure prophylaxis and post-exposure prophylaxis uptake and high prevalence of transmitted drug resistance among newly diagnosed primary HIV infections in Shenzhen, China: a real-world retrospective study显示文摘Background: Understanding the characteristics of newly diagnosed primary human deficiency virus-1 (HIV-1) infection in the context of the post-antiretroviral therapy era and HIV drug prophylaxis is essential for achieving the new target of 95-95-95-95 by 2025. This study reported the characteristics of newly diagnosed primary HIV-1 infection in Shenzhen.Methods: This is a real-world retrospective study. Eighty-seven newly diagnosed primary HIV-1-infected patients were recruited from January 2021 to March 2022 at the Third People’s Hospital of Shenzhen. Demographic, epidemiological, diagnostic, drug resistance, and medical data were described and analyzed.Results: Overall, 96.6% (84/87) of the newly identified primary HIV-1-infected patients were male, including 88.5% (77/87) men have sex with men (MSM), with a median age of 29.0 years (Q_(1)-Q_(3): 24.0-34.0 years);of these, 85.1% (74/87) reported high-risk sexual behaviors with casual partners. The rate of condom usage was only 28.7% (25/87). The overall rate of pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) was 8.0% (7/87, including 4 PrEP and 3 PEP cases) around the potential exposure, although 41.4% of the patients had prior awareness of such interventions. Moreover, only 19.5% (17/87) had previously used PrEP or PEP. Of those, 58.8% (10/17) of the patients obtained drugs from the internet, and only 35.3% (6/17) reported good compliance. A total of 54.0% (47/87) of subjects were diagnosed by the HIV nucleic acid test. Acute retroviral syndrome appeared in 54.0% (47/87) of patients. The prevalence of transmitted drug resistance (TDR) mutation was 33.9% (19/56), including 6 (10.7%) against nucleoside reverse transcriptase inhibitor (NRTI) plus non-nucleoside reverse transcriptase inhibitor (NNRTI), 8 (14.3%) against NNRTI, and 5 (8.9%) against protease inhibitor (PI) only.Conclusions: Owing to the low utilization rate and incorrect usage of PrEP and PEP, massive efforts are needed to promote HIV-preventive strategies in the MSM population. The extremely high prevalence of TDR mutation in this population implies the need for future pretreatment drug resistance surveillance. | Qiaoli Peng Xiaoning Liu Xian Tang Qiuyue Zhang Jin Zhao Chenli Zheng Fang Zhao Yang Zhou Lukun Zhang Liqin Sun Haitao Zhang Xinyun Jia Ying Song Tingzhi Cao Siyuan Wang Man Rao Zhiwei Chen Hui Wang Yun He | 2022 | Chinese Medical Journal2022，135，22： | 1 |
| 20 | Origin of symmetry breaking in the seed-mediated growth of bi-metal nano-heterostructures显示文摘Seed-mediated growth is the most general way to controllably synthesize bimetal nano-heterostructures.Despite successful instances through trial and error were reported, the way for second metal depositing on the seed, namely whether the symmetry of resulted nano-heterostructure follows the original crystal symmetry of seed metal, remains an unpredictable issue to date. In this work, we propose that the thermodynamic factor, i.e., the difference of equilibrium electrochemical potentials(corresponding to their Fermi levels) of two metals in the growth solution, plays a key role for the symmetry breaking of bimetal nano-heterostructures during the seed-mediated growth. As a proof-of-principle experiment, by reversing the relative position of Fermi levels of the Pd nanocube seeds and the second metal Au with changing the concentration of reductant(L-ascorbic acid) in the growth solution, the structure of as-prepared products successfully evolved from centrosymmetric Pd@Au core-shell trisoctahedra to asymmetric Pd-Au hetero-dimers. The idea was further demonstrated by the growth of Ag on the Pd seeds. The present work intends to reveal the origin of symmetry breaking in the seed-mediated growth of nano-heterostructures from the viewpoint of thermodynamics, and these new insights will in turn help to achieve rational construction of bimetal nano-heterostructures with specific functions. | Guifen Du Jun Pei Zhiyuan Jiang Qiaoli Chen Zhenming Cao Qin Kuang Zhaoxiong Xie Lansun Zheng | 2018 | Science Bulletin2018，63，14： | 1 |
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