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| 1 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 2 | Epidemiology of acute kidney injury in intensive care septic patients based on the KDIGO guidelines显示文摘 | Peng Qianyi Zhang Lina Ai Yuhang Zhang Lemeng | 2014 | Chinese Medical Journal2014，，10： | 24 |
| 3 | Effect of nitrogen concentration in culture mediums on growth and enzyme production of Phanerochaete chrysosporium显示文摘Effect of different nitrogen concentration in the mediums on growth and enzyme production of Phanerochaete chrysosporium was studied when glucose concentration was 10 g/L. The results showed that the medium contained 0.8 g/L ammonium tartrate is the best. It not only supply abundant nutrients for the growth of Phanerochaete chrysosporium, which make mycelia the best grow compared with the other medium, but also produce higher manganese-dependent peroxidase(Mnp) and laccase(Lac) activity. In addition, it is observed that the variation of mycelia surface is related to ligninolytic enzyme secreted by Phanerochaete chrysosporium. When the surface of mycelium pellets appeared burs, it predicts secondary metabolism begin. This experimentation demonstrated that when the ratio of carbon and nitrogen in nitrogen limited medium is equal to 100∶8, growth and enzyme production of Phanerochaete chrysosporium is the best, it could achieve the maximum Mnp and Lac activity. | GAODa-wen WENXiang-hua QIANYi | 2005 | Journal of Environmental Sciences2005，17，2： | 16 |
| 4 | Decolorization of reactive brilliant red K-2BP with the white-rot fungi under non-sterile conditions显示文摘 | GAODawen WENXianghua QIANYi | 2004 | Chinese Science Bulletin2004，49，9： | 12 |
| 5 | Sponge spicules in phosphorites of the Early Cambrian Gezhongwu Formation,Zhijin,Guizhou显示文摘Phosphorites occurring at the bottom of the Cambrian system contain abundant small shelly fossils,which are the prod-uct of the first episode of life explosion in the Cambrian.It was previously reported that the small shelly fossils are dominated by hy-olithids,olivooids,zhijinitids,conodontomorphs,yubelichitids,camenitids and algae,with minor amounts of sponge fossils.Large amounts of sponge spicules,diverse in form,have been found for the first time in the Gezhongwu Formation phosphorites at Shixing,Zhi-jin County,Guizhou Province,of which such spicules as diaxon-triactins,diaxon-tetractins,pentaxon-pentactins and hexon-hexactins ac-count for30%.These spicules constitute the sponge clastic phosphorites made up of sponge clastics.Meanwhile,it is also expected that the radiation and diversity of sponge animals started as early as in the earliest Early Cambrian.Habit and burying environment of sponge animal are discussed in the paper. | YANGRuidong QIANYi ZHANGJie ZHANGWeihua JIANGLijun GAOHui | 2004 | Progress in Natural Science:Materials International2004，14，10： | 8 |
| 6 | Two-dimensional optical spatial differentiation and high-contrast imaging显示文摘Optical analog signal processing technology has been widely studied and applied in a variety of science and engineering fields, with the advantages of overcoming the low-speed and high-power consumption associated with its digital counterparts. Much attention has been given to emerging metasurface technology in the field of optical imaging and processing systems. Here, we demonstrate, for the first time, broadband two-dimensional spatial differentiation and high-contrast edge imaging based on a dielectric metasurface across the whole visible spectrum. This edge detection method works for both intensity and phase objects simply by inserting the metasurface into a commercial optical microscope. This highly efficient metasurface performing a basic optical differentiation operation opens up new opportunities in applications of fast,compactible and power-efficient ultrathin devices for data processing and biological imaging. | Junxiao Zhou Haoliang Qian Junxiang Zhao Min Tang Qianyi Wu Ming Lei Hailu Luo Shuangchun Wen Shaochen Chen Zhaowei Liu | 2021 | National Science Review2021，8，6： | 6 |
| 7 | Early Cambrian protoconodonts and conodont-like fossils from China: Taxonomic revisions and stratigraphic implications显示文摘Protoconodonts and conodont-like microfossils are characteristic components in the early Cambrian skeletal faunas. Since the 1970s, these tooth-like phosphatic sclerite fossils have been widely recovered from the Lower Cambrian of China, and altogether 25 genera and 52 species of protoconodonts and conodont-like fossils have been described, although some taxa represent synonyms or invalid taxonomic names, and some assignments are apparently inappropriate. Through a brief review and discussion, the distinction between protoconodonts and conodont-like fossils is denoted here. There are 13 genera previously assigned to protoconodonts in the literature, but present taxonomic revisions show that 5 of them are junior synonyms of other taxa, and 2 represent unknown arthropods. The other 12 genera, of which 5 also are junior synonyms, only reveal a conodont-like morphology with various zoological affinities: most of them are enigmatic, and only Beshtashella and Parafomitchella (= Beshtashella ) can be assigned to mollusks. The spatial and temporal distribution of the most genera is briefly discussed. Three intervals of stratigraphic distribution for the protoconodonts not only have significant implications for stratigraphic correlations but also may reflect their evolutionary trend. | QIANYi LIGuoxiang ZHUMaoyan MichaelSTEINER Bernd-D.ERDTMANN | 2004 | Progress in Natural Science:Materials International2004，14，2： | 5 |
| 8 | Mechanism underlying effect of Chaihu Shugan San(柴胡疏肝散)on major depressive disorder:a network pharmacology-based study显示文摘OBJECTIVE:To investigate the mechanism underpinning the effect of Chaihu Shugan San(柴胡疏肝散,CHSGS)on major depressive disorder(MDD).METHODS:We searched the compound components of from seven herbal ingredients of CHSGS from TCMSP,SymMap,ETCM,NPASS databases,and the chemical structure of the compound from PubChem,and collected the compound targets from TCMSP and TargetNet databases,and MDD-related targets from DiseaseGene Network.We established protein-protein interaction in the STRING database.Through gene mapping,topology analysis and enrichment analysis,the core targets and pathways of CHSGS for MDD,and the involved biological processes(BP),cell components(CC),and molecular functions(MF)were predicted.RESULTS:We collected a total of 1135 CHSGS compounds.After screening by ADME standards and the five rules of Ribinski,we obtained 99 different chemical components with different chemical structures,and related targets of 183 different CHSGS compounds.In the DiseaseGene Network,a total of 740 relevant targets for MDD were collected.Through gene mapping and topological analysis,62 related targets of CHSGS for MDD,24 targets with topological Chinese herbal medicine were obtained.Through enrichment analysis,10 relevant pathways and 3 core pathways were obtained with the involvement of 127 BP,27 CC,and 43 MF.CONCLUSION:There are multiple targets and signaling pathways are involved in the action of CHSGS in the treatment of MDD. | MU Jie ZHANG Shuang TANG Feifei LIU Shuling ZHANG Qianyi DU Qianlei WANG Xueqian WANG Qingguo CHENG Fafeng | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 4 |
| 9 | Graphene-manganese oxide hybrid porous material and its application in carbon dioxide adsorption显示文摘Graphene-Mn3O4 (GMNO) hybrid porous material is prepared by a hydrothermal method and its performance in carbon dioxide adsorption is investigated.In the synthesis of the GMNO materials,MnO(OH)2 colloid obtained by the hydrolysis of Mn 2+ in basic solution was using as the precursor of the Mn3O4.After a hydrothermal reaction of the mixture of graphene oxide (GO) and MnO(OH)2,GO was reduced into graphene and the MnO(OH)2 was transformed into Mn3O4 with enhanced crystallization.X-ray diffraction,thermal gravimetric analysis,transmission electron microscopy,infrared spectra and Raman spectroscopy were taken to characterize the hybrid material.The porosity and the carbon dioxide adsorption ability are measured by gas sorption analysis,in which the as-prepared GMNO hybrid materials exhibit a specific surface area ranging from 140 to 680 m2g-1 and a maximum carbon dioxide capacity of about 11 wt%. | ZHOU Ding LIU Qing CHENG QianYi ZHAO YanChao CUI Yi WANG Tao HAN BaoHang | 2012 | Chinese Science Bulletin2012，57，23： | 4 |
| 10 | Experimental Study on Rack Cooling System based on a Pulsating Heat Pipe显示文摘A rack cooling system based on a large scale flat plate pulsating heat pipe is proposed. The heat generated from IT equipment in a closed rack is transferred by the rear door pulsating heat pipe to the chilled air passage and is avoided to release into the room. The influence of the start-up performance of the heat pipe, the load of the rack and the load dissipation to the temperature and the velocity distribution in the rack are discussed. It is found that the temperature would be lower and the temperature distribution would be more uniform in the rack when the pulsating heat pipe is in operation. Also, the effect of rack electricity load on temperature distribution is analyzed. It is indicated that higher velocity of chilled air will improve heat transfer of the rack. | LU Qianyi JIA Li | 2016 | Journal of Thermal Science2016，25，1： | 3 |
| 11 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 12 | Molecular Isolation of the M Gene Suggests That a Conserved-Residue Conversion Induces the Formation of Bisexual Flowers in Cucumber Plants显示文摘 | Li Zheng Huang Sanwen Liu Shiqiang Pan Junsong Zhang Zhonghua Tao Qianyi Shi Qiuxiang Jia Zhiqi Zhang Weiwei Chen Huiming Si Longting Zhu Lihuang Cai Run | 2009 | Genetics2009，，4： | 2 |
| 13 | Radiotherapy-induced heart disease:a review of the literature显示文摘Radiotherapy as one of the four pillars of cancer therapy plays a critical role in the multimodal treatment of thoracic cancers.Due to significant improvements in overall cancer survival,radiotherapy-induced heart disease(RIHD)has become an increasingly recognized adverse reaction which contributes to major radiationassociated toxicities including non-malignant death.This is especially relevant for patients suffering from diseases with excellent prognosis such as breast cancer or Hodgkin’s lymphoma,since RIHD may occur decades after radiotherapy.Preclinical studies have enriched our knowledge of many potential mechanisms by which thoracic radiotherapy induces heart injury.Epidemiological findings in humans reveal that irradiation might increase the risk of cardiac disease at even lower doses than previously assumed.Recent preclinical studies have identified non-invasive methods for evaluation of RIHD.Furthermore,potential options preventing or at least attenuating RIHD have been developed.Ongoing research may enrich our limited knowledge about biological mechanisms of RIHD,identify non-invasive early detection biomarkers and investigate potential treatment options that might attenuate or prevent these unwanted side effects.Here,we present a comprehensive review about the published literature regarding clinical manifestation and pathological alterations in RIHD.Biological mechanisms and treatment options are outlined,and challenges in RIHD treatment are summarized. | Bingwen Zou Julius Philipp Schuster Kerun Niu Qianyi Huang Alexander Rühle Peter Ernst Huber | 2019 | Precision Clinical Medicine2019，2，4： | 2 |
| 14 | Using a zeolite medium biofilter to remove organic pollutant and ammonia simultaneously显示文摘A pilot scale zeolite medium biological aerated filter(ZBAF) was designed and used to treat municipal wastewater. It showed that ZBAF could simultaneously remove chemical oxygen demand(COD), ammonia-N and turbidity to satisfied degree at a hydraulic retention time(HRT) of 0.95 h. Their average removal efficiencies were 73.9%, 88.4% and 96.2% with the corresponding average effluent concentrations of 43.4 mg/L, 3.5 mg/L and 3.7 NTU, respectively. These effluent items met with the water quality standard of the treated water reused for cooling water. The COD removal volumetric loading rate increased proportionally with its applied volumetric loading rate with its maximum of 7.1 kg/(m 3·d). Ammonia-N removal loading rate also increased proportionally with its applied loading rate at HRT of longer than 0.95 h and the feasible maximum removal loading rate was 0.9 kg/(m 3·d). The COD loading rate did not affect the ammonia-N removal efficiency significantly when it was lower than 5.5 kg/(m 3·d). ZBAF has good application prospect for its low cost and high removal efficiency in the future. | TIANWen-hua WENXiang-hua QIANYi | 2004 | Journal of Environmental Sciences2004，16，1： | 2 |
| 15 | Differentiation and Pro-Angiogenic Potential of Infantile Hemangioma Stem Cells显示文摘Objectives Infantile hemangioma(IH)is defined as a benign vascular tumor composed of immature vascular endothelial cells,with the unique characteristics of rich vascularization and self-regression into fibro-fatty tissue.CD133-positive hemangioma stem cells(HemSCs),present in the proliferating IH tissue,can be used to establish the IH animal model,which has highlighted the pathogenesis of IH in recent years.This study focused on the biological characteristics and differentiation capacity of HemSCs and aimed to provide a theoretical possibility for its application in tissue engineering.Methods To further confirm our hypothesis,we used fluorescence-activated cell sorting(FACS),in vitro multipotent induced differentiation,angiogenesis assay,and antibody array to identify the surface markers,multipotent differential potential,angiogenesis potential,and secreted factors of HemSCs,respectively,utilizing human adipose stem cells(hADSCs)as the control.Results We successfully isolated and cultured HemSCs.FACS indicated that,on average,more than 80%of HemSCs matched the criteria of mesenchymal stem cell(MSC)surface markers.Our results confirmed that HemSCs could differentiate into adipocytes,osteocytes,and chondrocytes.Additionally,compared with fibroblasts or hADSCs,HemSCs could promote angiogenesis through para-secretion.Conclusions HemSCs may originate from normal MSCs,and owing to their powerful proliferative and angiogenic abilities,they could be considered an IH pathogenic factor.These characteristics demonstratet heir potential as a candidate seed cell in tissue engineering. | Hanru YING Qianyi CHEN Xuanfeng CHEN Zhang YU MD Shih-Jen CHANG Lei CHANG Gang MA Yajing QIU Hui CHEN Xiaoxi LIN | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，1： | 2 |
| 16 | Tunable magneto-optical polarization device for terahertz waves based on InSb and its plasmonic structure显示文摘The nonreciprocal circular dichroism and Faraday rotation effect for terahertz(THz) waves in longitudinally magnetized InSb were investigated by theoretical and experimental studies in the THz regime, which indicated its ability for a THz circularly polarized isolator, THz circular polarizer, tunable polarization converter, and polarization modulator by manipulation of different magnetic fields. Furthermore, we demonstrated the InSb plasmonics based on its magneto-optical effects combined with artificial microstructure. We found the magnetooptical enhancement mechanisms in this magneto-plasmonic structure, achieving broadband near-perfect orthogonal linear polarization conversion modulated by the weak magnetic field in an experiment with an extinction ratio of 33 dB. Moreover, the magneto-optical modulation with an amplitude modulation depth of 95.8% can be achieved by this device under a weak magnetic field of 150 mT. InSb and its magneto-plasmonic device have broad potential for a THz isolator, magneto-optical modulator, and polarization convertor in THz application systems. | QIANYI MU FEI FAN SAI CHEN SHITONG XU CHUANZHONG XIONG XIN ZHANG XIANGHUI WANG SHENGJIANG CHANG | 2019 | Photonics Research2019，7，3： | 2 |
| 17 | The Cambian and Ordovician strata ineastern Yangtze Gorge area Hubei显示文摘 | ZhangWen—tang(张文堂) LiJi—jin(李积金) QianYi—yuan(钱义元) ZhuZhao—ling(朱兆玲) ChenChuzhen(陈楚震) ZhangShou—xin(张守信) | 1957 | 古生物学报1957，5，1： | 1 |
| 18 | H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet显示文摘 | Qianyi Zhang Jianzhong Shi Guohua Deng Jing Guo Xianying Zeng Xijun He Huihui Kong Chunyang Gu Xuyong Li Jinxiong Liu Guojun Wang Yan Chen Liling Liu Libin Liang Yuanyuan Li Jun Fan Jinliang Wang Wenhui Li Lizheng Guan Qimeng Li Huanliang Yang Pucheng Che | 2013 | Science2013，，6144： | 1 |
| 19 | Study on the relationship ofthe structure and toxicity of alcohols, aldehydes and acids 显示文摘 | Qianyi Z Ting X Menghua L | 2014 | AdvBiomed Pharma2014，1，1： | 1 |
| 20 | Key MolecularFactors in Hemagglutinin and PB2 Contribute to Efficient Transmission of the 2009 HlNl Pandemic Influenza Virus显示文摘 | Ying Zhang Qianyi Zhang Yuwei Gao | 2012 | Journal of Virology2012，18，86： | 1 |
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